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Database: UniProt
Entry: F6ZZ74_ORNAN
LinkDB: F6ZZ74_ORNAN
Original site: F6ZZ74_ORNAN 
ID   F6ZZ74_ORNAN            Unreviewed;       391 AA.
AC   F6ZZ74;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   16-OCT-2019, entry version 43.
DE   SubName: Full=NHL repeat containing E3 ubiquitin protein ligase 1 {ECO:0000313|Ensembl:ENSOANP00000018783};
GN   Name=NHLRC1 {ECO:0000313|Ensembl:ENSOANP00000018783};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000018783, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000018783}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000018783};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   STRING; 9258.ENSOANP00000018783; -.
DR   Ensembl; ENSOANT00000018786; ENSOANP00000018783; ENSOANG00000011852.
DR   eggNOG; ENOG410ITF2; Eukaryota.
DR   eggNOG; ENOG410ZMHC; LUCA.
DR   GeneTree; ENSGT00730000111361; -.
DR   InParanoid; F6ZZ74; -.
DR   TreeFam; TF331018; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000011852; Expressed in 4 organ(s), highest expression level in heart.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0006914; P:autophagy; IEA:Ensembl.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0045859; P:regulation of protein kinase activity; IEA:Ensembl.
DR   GO; GO:1903076; P:regulation of protein localization to plasma membrane; IEA:Ensembl.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
DR   Gene3D; 2.120.10.30; -; 2.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR013017; NHL_repeat_subgr.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF14634; zf-RING_5; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS51125; NHL; 6.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT   DOMAIN       25     71       RING-type. {ECO:0000259|PROSITE:PS50089}.
FT   REPEAT      120    163       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
FT   REPEAT      167    210       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
FT   REPEAT      218    251       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
FT   REPEAT      267    300       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
FT   REPEAT      323    349       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
FT   REPEAT      360    391       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
SQ   SEQUENCE   391 AA;  40973 MW;  BF1CE9D39DE289FB CRC64;
     AAEPSDDVRP APGPLGEIQV RLLECQVCFE KHGARKERRP RNLPCGHVVC LECVVALAHP
     ETLTFLCPFC RRPCKSSETG DCLPLLQLLE ILEPRSARPA APPAEAAVTL RARPRAPGPF
     VLHRTFGGWG TLLNPTGMAL GPGDGRVVVA HDGRRRVRVF DAQGGCVRQF GKRGEAGGDV
     RYPLDVAVTP DGCVVVTDAG ARAVKGFDPA GRPGLVVRAP FRLPWGAAVT PGGAVLVTDL
     EAGALFRLEA DVAAGMVREV RRLRAGLLGP RGVAVCPRDG AVAVLEHGGP GLRVKVFSAA
     MRLLGQVDPF GLSLLFPAEM DATAVTFDPE GDVVIADALH GAVVSLGRPG AALVVRPLVT
     QGLSYPVALG YSEDKSLLVL DGGAHSVAVF K
//
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