ID F7A2J7_HORSE Unreviewed; 1425 AA.
AC F7A2J7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=FA complementation group D2 {ECO:0000313|Ensembl:ENSECAP00000016788.4};
GN Name=FANCD2 {ECO:0000313|Ensembl:ENSECAP00000016788.4,
GN ECO:0000313|VGNC:VGNC:17901};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000016788.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000016788.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016788.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000016788.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016788.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9796.ENSECAP00000016788; -.
DR PaxDb; 9796-ENSECAP00000016788; -.
DR Ensembl; ENSECAT00000020455.4; ENSECAP00000016788.4; ENSECAG00000018519.4.
DR VGNC; VGNC:17901; FANCD2.
DR GeneTree; ENSGT00390000016970; -.
DR HOGENOM; CLU_002068_1_0_1; -.
DR InParanoid; F7A2J7; -.
DR OMA; YLYCGAY; -.
DR TreeFam; TF101106; -.
DR Proteomes; UP000002281; Chromosome 16.
DR Bgee; ENSECAG00000018519; Expressed in bone marrow and 15 other cell types or tissues.
DR GO; GO:0000793; C:condensed chromosome; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0070182; F:DNA polymerase binding; IBA:GO_Central.
DR GO; GO:1990918; P:double-strand break repair involved in meiotic recombination; IBA:GO_Central.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IBA:GO_Central.
DR GO; GO:0036297; P:interstrand cross-link repair; IBA:GO_Central.
DR GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IBA:GO_Central.
DR CDD; cd11721; FANCD2; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR029448; FANCD2.
DR PANTHER; PTHR32086; FANCONI ANEMIA GROUP D2 PROTEIN; 1.
DR PANTHER; PTHR32086:SF0; FANCONI ANEMIA GROUP D2 PROTEIN; 1.
DR Pfam; PF14631; FancD2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 856..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1375..1425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..908
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1375..1397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1404..1425
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1425 AA; 160963 MW; 12B90E556A4B19E9 CRC64;
MVSKRRLSKS EEKESPTEDA SQARKQPLSK KTKKSRVHSE VEENDSVFVK LLKTSGIILK
TGESQHQLAV DQIIFQKKLF QTLKKHPSYP KIIEEFISGL ESYIEDQDSF RNCLVSCERL
QDEEASMGTS YSKSLIKLLL GIDILQPAII KTLFEKLPEF LFEKVNTDGI SMPRLIISQL
KWLDRVVDGK DLTTKIMQLI SIAPVYLQHD FITSLPEIVG DSQHADVGKE LSDLLTENTS
LTVPILDVLS SLRLDPKLVS EVRQLVMGKL SSVRLDDLPV IIKFILHSVT TTDALEVISE
LREQLDLQHC VLPSQLQTSQ SRLKSKGRRS SSGNQENSGQ DCVILLFDVI KSAVRYEKTI
SEAWIKAIES TPSGSEHKIF DLTMLLIIYS TNTQTKKYIE RVLRNKIRSG CFQEQLLQST
FYVHYLVLKD VCPSILSLAQ SFLHSLDQSI ILFGSLLYKY AFKFFDTYCQ QEVVGALVTH
ICSGNEAEVD TALDILLDLV VVNLSAMRLN AVFVKGILDY LENMSPQQIR KLFYILSTLA
FSKQHEASSH IQDDMHLVIR KQLSSTIFKY KLIGIIGAVT MAGIMAADRS SSLTQGRAAL
SSEQCTQVTS LLQLVHSCSK QSPWASALYY DEFANLIQGG KLAPKALEWA GQTIFNDFQD
AFVVDFCAVP EGDYPFPVKA LYGLEEYSSH DGIAINLLPL LFSEDFAKDG GRMTSQESDQ
KLVSPLCLAP YFRLLRLCVE RQHNGNLEEI DGLLDCPVFL TDLEPGERLE SMSVKEHSFL
CSLIFLTLNW FREVVNGFCQ QKSPEMKGKV LTRLKHIVEL QRILEKYLAD IPDYVPPPAN
FDLETLDITP HTSTAVSAKI RKQGNIGGRK RKADDSKTSS SDTLSKEDSS ECDPTSSDRS
QLEKDFKGKE EKMSVSLQNY RAFFRELDIE VFSILHCGLV TKCILDTEMH TEATEVVQLQ
PPELLFLLED LSQKVENMLT PSVARRVPFL KSKGSRNIGF SHLHQRSAQE IAHSIVRLLT
PMCNHLENIH NYFQCLAAEN QGVVDGPGVK GQEYHIMSSC YQRLLQTFHG LFAWSGFFQP
ENYNLLYSAL EVLTNRLKQR EPDQPLEELL SQSFHYLQNF RHSIPSFHCA LYLIRLLMVL
LEKSTAPTQN KEKIASLARQ FLCRVWPRGE KENSNIPNDQ LHVLLSIYLE HTDSVLKAIE
EIAGVGVPEL INSPKDASSS TFPTLTRHTF VIFFRVMMAE LEKTVKGLQA GTAADSQQIH
EEKLLYWNMA VRDFSILINL IKVFDSRPVL HVCLKEDVLS LLETFQLNTR LLHHLCGHSK
IHQDTKLTKH VPLLKKTLEL LVCRVKAMLV LNNCREAFWL GNLKNRDLQG EEIISQNSQE
STADESGDDA SSQVSKSKAT EDGEDDEASD GEKEQDSDES DDDSD
//