ID F7A2S6_XENTR Unreviewed; 1084 AA.
AC F7A2S6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 24-JAN-2024, entry version 60.
DE RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
GN Name=tmtc1 {ECO:0000313|Ensembl:ENSXETP00000000679};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000000679};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000000679}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000000679};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000000679}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMTC family.
CC {ECO:0000256|ARBA:ARBA00007882}.
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DR AlphaFoldDB; F7A2S6; -.
DR Ensembl; ENSXETT00000000679; ENSXETP00000000679; ENSXETG00000000326.
DR eggNOG; KOG1124; Eukaryota.
DR HOGENOM; CLU_011615_1_1_1; -.
DR TreeFam; TF328339; -.
DR UniPathway; UPA00378; -.
DR Bgee; ENSXETG00000000326; Expressed in brain and 8 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR013618; TMTC_DUF1736.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44809; -; 1.
DR PANTHER; PTHR44809:SF1; PROTEIN O-MANNOSYL-TRANSFERASE TMTC1; 1.
DR Pfam; PF08409; TMTC_DUF1736; 1.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF13432; TPR_16; 1.
DR Pfam; PF14559; TPR_19; 2.
DR Pfam; PF13181; TPR_8; 2.
DR SMART; SM00028; TPR; 10.
DR SUPFAM; SSF81901; HCP-like; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 6.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 232..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 513..533
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 553..574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 586..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 491..563
FT /note="DUF1736"
FT /evidence="ECO:0000259|Pfam:PF08409"
FT REPEAT 682..715
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 781..814
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 815..848
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 882..915
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 988..1021
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1022..1055
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1084 AA; 120008 MW; 4DA6594178DA38D2 CRC64;
MSSGEGGSSR SRGGRNGVGQ SMPKEIPEDK VPRDAGNGAK RSHLRANGRG LCSGPKMFKQ
ELPKKDASDA PGQSIVTGVP SSTANGAGQS QLRSLPNEKG TFSGEKNISQ SPQDTPNIID
QNGTKGLPKG TSNGMAQRIL GEMATSNGAA QRILGEMATS NGAAQELIRE KGMTNGTVQE
VLRDKGISKV PAQGTLANTT RSLVNGTSGV RPHSARKPGD DHLVFLPSGT SLGHWVLALP
AILATLCFVR SVFGEFVHDD VWAILNNPDS RAETPLSSIF GNDFWGKAMN DNTSHKSYRP
LCVLSFRINV FLGGLNAIYF HAINIVLHAA VSSLLMFTCS TAVFEDKRLA LAAALLFSAH
PIHTEAVAGI VGRADVLSCL LFLLTFLSYI RSMDSGPPRH SFPPTSAPLF LLLSLILGTG
AVLVKETGIT VFGVCLTYDL LLLCPTRCKR YSSPDPRASI WYVAGPFLKR AALVSLYVAL
VLYFRLRIMG GSMPLFSEQD NPASFSPYPL TRFLTYLYLL AFNSWLLLAP ITLCYDWQVG
SIPLINSLWD VRNLATLLFV GIVGSLALHC LAFLKRAPRR EVLVGLLFLV FPFIPASNLF
FRVGFVVAER VLYMPSMGFC ILCVHGLKVL QSHVGQRRSL SLTLCFLFLL LLFSCKSLSQ
SECWRSREAL FRSGVQTLPH NAKVHYNYAN FLKDQSRKDE AIMHYKTVLR LYPKHSSALN
NLGTLTANTT EAEEYYRRAL MISPQHSRAL FNLGNLLRNK GQDDEAELLL RESLHYGSYF
GDAYSSLGSL LADQKRYEEA DDVYQTGIKS CPENSDLHNN YGVFLVDMEK SQKAESHYLH
ALHLRPDHHV AMLNLGRLYR SLGQNKEAEK WYRKALQISR EADVISPLGA LLYNTGQHEE
ARRLYQEAVG LHPRNIQIRL SLAQVLAVLG QIHEAEALAY GIAAEVPDCT ECFRLLSAIY
SKREDYVKAL ELIDFALQMK SNDAKLLSEL HFTRGNQLRE LNHLEEAFQS YERVAELNPT
QAQAWMNMGG IRHMQGDYTS ARAFYQKAAV LDPDSKLLKE NLAKLQRIEN RLQGTKAKDQ
IKDK
//
