ID F7A5M5_MONDO Unreviewed; 1786 AA.
AC F7A5M5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Laminin subunit beta 1 {ECO:0000313|Ensembl:ENSMODP00000020390.3};
GN Name=LAMB1 {ECO:0000313|Ensembl:ENSMODP00000020390.3};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000020390.3, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000020390.3, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000020390.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR RefSeq; XP_001363841.1; XM_001363804.4.
DR RefSeq; XP_007504184.1; XM_007504122.2.
DR STRING; 13616.ENSMODP00000020390; -.
DR Ensembl; ENSMODT00000020748.4; ENSMODP00000020390.3; ENSMODG00000016246.4.
DR GeneID; 100010605; -.
DR KEGG; mdo:100010605; -.
DR CTD; 3912; -.
DR eggNOG; KOG0994; Eukaryota.
DR GeneTree; ENSGT00940000156003; -.
DR HOGENOM; CLU_001560_1_0_1; -.
DR InParanoid; F7A5M5; -.
DR OMA; AMDFDQD; -.
DR OrthoDB; 90222at2759; -.
DR TreeFam; TF312903; -.
DR Proteomes; UP000002280; Chromosome 8.
DR Bgee; ENSMODG00000016246; Expressed in extraembryonic membrane and 20 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0043256; C:laminin complex; IBA:GO_Central.
DR GO; GO:0005606; C:laminin-1 complex; IEA:Ensembl.
DR GO; GO:0043259; C:laminin-10 complex; IEA:Ensembl.
DR GO; GO:0005607; C:laminin-2 complex; IEA:Ensembl.
DR GO; GO:0043257; C:laminin-8 complex; IEA:Ensembl.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IEA:Ensembl.
DR GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0070831; P:basement membrane assembly; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0035987; P:endodermal cell differentiation; IEA:Ensembl.
DR GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
DR GO; GO:0021812; P:neuronal-glial interaction involved in cerebral cortex radial glia guided migration; IEA:Ensembl.
DR GO; GO:0042476; P:odontogenesis; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0034446; P:substrate adhesion-dependent cell spreading; IBA:GO_Central.
DR GO; GO:0009888; P:tissue development; IBA:GO_Central.
DR CDD; cd22300; cc_LAMB1_C; 1.
DR CDD; cd00055; EGF_Lam; 13.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 2.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013015; Laminin_IV_B.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF435; LAMININ SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 13.
DR Pfam; PF21199; LAMININ_IV_B; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00180; EGF_Lam; 13.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 13.
DR PROSITE; PS01248; EGF_LAM_1; 5.
DR PROSITE; PS50027; EGF_LAM_2; 10.
DR PROSITE; PS51116; LAMININ_IVB; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1786
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023816948"
FT DOMAIN 31..270
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 271..334
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 398..457
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 458..509
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 549..767
FT /note="Laminin IV type B"
FT /evidence="ECO:0000259|PROSITE:PS51116"
FT DOMAIN 773..820
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 821..866
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 867..916
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 976..1027
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1028..1083
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1084..1131
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1132..1178
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT COILED 1250..1312
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1458..1513
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1561..1668
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1698..1774
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 300..309
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 428..437
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 481..490
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 493..507
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 773..785
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 775..792
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 794..803
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 821..833
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 823..840
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 842..851
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 886..895
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1000..1009
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1028..1040
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1056..1065
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1084..1096
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1086..1103
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1105..1114
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1132..1144
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1134..1151
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1153..1162
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1786 AA; 197613 MW; 26C7BEE58966AA79 CRC64;
MGLLQVHLFG FLALWGVSVQ AQEPEYSYGC AEGSCYPATG DLLIGRAQKL SVTSTCGLHK
PEPYCIVSHL QEDKKCFMCN SQDPYHETLN PDSHLIENVV TTFAPNRLKI WWQSENGVEN
VTIQLDLEAE FHFTHLIMTF KTFRPAAMLI ERSSDFGKTW GVYRYFAYDC ESSFPGVSTG
PMKKVDDIIC DSRYSDIEPS TEGEVIFRAL DPAFKIEDPY SPRIQNLLKI TNLRIKFVKL
HTLGDNLLDS RIEIREKYYY AVYDMVVRGN CFCYGHASEC APVDGHSEEV EGMVHGHCMC
RHNTKGLNCE LCMDFYHDLP WRPAEGRNSN ACKKCNCNEH SGSCHFDMAV YLATGNISGG
VCDDCQHNTM GRNCEQCKPF YYQHPERDIR DPNICAACTC DPAGSKNGGI CDGYTDFSTG
LIAGQCRCKL YTEGEKCDIC KEGFYGLSAD DPFGCQSCAC NPLGTIPGGN PCDSETGYCY
CKRLVTGQHC DQCLQEHWGL SNDLDGCRPC DCDVGGSLNN NCSAESGQCL CRPHMIGRQC
NEVEAGYYFT TLDHYIYEAE EAHFGPGVSI VERQYIQDRI PSWTGAGFVR VPEGAYLEFF
IDNIPYSMEY DILIRYEPQL PDHWEKAVIT VQRPGKIPTS SRCGNTVPDD DNQSVSLSPG
SRYVVLPRPV CFEKGVNYTV RLELPHYTSS DSGIESPYTL IDSLVLMPYC KSLDIFTVGG
SGDGLITNSA WETFQRYRCL ENSRSVVKTP MTDVCRNIIF SISALLHQSG LACECDPQGS
LSSVCDPNGG QCQCRPNVVG RTCDRCAPGT FGFGPSGCKP CDCHVQGSVN AFCDPVTGQC
HCFQGIYTRQ CDQCLRGYWG FPSCQPCQCN GHADDCDPIS GECFGCQDYT SGHNCERCLP
GYYGDPVIGS GDHCRPCPCP DGPESGRQFA NTCYQDPVTL QLVCVCNPGY LGARCNECAS
GYFGNPEDVD GVCQQCQCHN NIDTTDPEAC DKRTGRCLKC LYHTEGENCQ LCKYGYYGDA
LQQDCRKCVC NYLGTVQEHC DGSDCQCDKI TGQCLCLPNV IGQNCDHCAP NTWNLASGTG
CEPCSCDAAH SFGPSCNEFT GQCQCMPGFG GRTCDECQEL FWGDPNVKCQ ACDCDPRGIE
IHQCDRVTGQ CVCIEGVEGP RCDKCTRGYS GIFPDCAPCH ECFALWNAII AELTNRTHKF
LEKAKALKIS GVIGPYRETV DNVEKKINEI KSILAQSPAA EPLKNIGNLF EEAEKLTKDV
TEKMSEVEAK LSDAASKSNS TVEELDSLQM DAQSLDKTVK ELAEQLEFIK NSDIRGALDS
ITKYFQISLE AEERVNASTT DPNSIVEQSA FTRNKVEELM MERETQFREK QEEQSRLLDE
LAGKLQSLDL SAAAEQTCGT PPGASCAETP CGGPSCRTDD GEKKCGGPGC DGLVTVAHNA
WQKAMDFDRD VLSALAEVEQ LSKTVSEAKL RADEAKQSAQ AVLLKTNATK EKVDKSNEDL
RNLIKQIRNF LTQDSADLDS IEAVANEVLK MEMPSTPQQL QNLTEDIRER VESLSQVEVI
LQQSAGDIAR AEMLLDEAKR ASKSATDIKV TTDMVKEALE EAEKAQIAAE KAIKQADEDI
QGTQNLLTSI ESETAASEET LYNASQRISE LERNVEELKR KAAQNAGEAE YIGQVVDTVK
QSADHVKKVL DSELSGKYKR VENLIAKKTE ESVDARKKAE MLQNEAKMLL AQANSKLQLL
KDLEQKYEDN QKYLEDKAQE LVKLEEEVRL LLQDISQKVA VYSTCL
//
