ID F7A7C4_XENTR Unreviewed; 834 AA.
AC F7A7C4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Follistatin-like 4 {ECO:0000313|Ensembl:ENSXETP00000034812};
DE SubName: Full=Follistatin-related protein 4 {ECO:0000313|RefSeq:XP_031754586.1};
GN Name=fstl4 {ECO:0000313|Ensembl:ENSXETP00000034812,
GN ECO:0000313|RefSeq:XP_031754586.1,
GN ECO:0000313|Xenbase:XB-GENE-876781};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000034812};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000034812}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000034812};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000034812}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_031754586.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031754586.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031754586.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR RefSeq; XP_031754586.1; XM_031898726.1.
DR PaxDb; 8364-ENSXETP00000028940; -.
DR Ensembl; ENSXETT00000034812; ENSXETP00000034812; ENSXETG00000015944.
DR KEGG; xtr:100493496; -.
DR AGR; Xenbase:XB-GENE-1013105; -.
DR AGR; Xenbase:XB-GENE-876781; -.
DR Xenbase; XB-GENE-876781; fstl4.
DR eggNOG; ENOG502QPNV; Eukaryota.
DR HOGENOM; CLU_007849_0_0_1; -.
DR OMA; RYLPVCG; -.
DR OrthoDB; 90320at2759; -.
DR TreeFam; TF350473; -.
DR Proteomes; UP000008143; Chromosome 3.
DR Bgee; ENSXETG00000015944; Expressed in ectoderm-derived structure and 2 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05736; IgI_2_Follistatin_like; 1.
DR CDD; cd00104; KAZAL_FS; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR10913; FOLLISTATIN-RELATED; 1.
DR PANTHER; PTHR10913:SF9; FOLLISTATIN-RELATED PROTEIN 4; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF07648; Kazal_2; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF75011; 3-carboxy-cis,cis-mucoante lactonizing enzyme; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..834
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041117549"
FT DOMAIN 81..135
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 173..208
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 233..320
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 338..423
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 834 AA; 94510 MW; 2BED4A26038BA240 CRC64;
MGSRSLWMLL LLLRVLLPTT FGWVDSERSR RFNTASGRLH LKAQENYDQT RRKVREVKDG
FTSPCEKKSC GQGRRCVISL GSKVPQCECL EKCKPRYMPV CGSDGKLYEN HCELHRASCL
HRKKIYIVHS KDCFFKDDTC TMADYNRLKS ILLDLQANRK NTQSSPMEDK RSQKRALVEN
LFNYLDMNND GHLDSFELAQ YAKEKELDNG LDCSVEDLLR FDDYNIDGDL TLPEFYTAFQ
VIQLTLAQEE MISVTTVTVG LSAVLTCAIH GILRPPIIWK RNGVILNYLD LEDINDFGED
NSLYITKVTT IHMGNYTCHA YGYEDLYQTH ILQVNVPPVI RVYPETQAQE PGVSASLKCH
AEGIPSPKIT WLKNGIDVTP RLSKQLTVLG NGSELHITSV RYEDTGAYTC IAKNEVGVDE
DISSLFIEDS AKKTLANILW REEGLSVGNM FYVFSDDGIT VIQPRECEVR RQMKPTERIL
TSYEEMCDKG QLCQWSSAIN VRNKFIYVAQ HVQNRILLID IQMQKVKQSI GVDPFPAKLF
YDKSHDQVWV LSWGDVRRSH PTLQVISDAS VGENLHIIRT TFENVDDFFI PPTNLIINHV
RFGFLFNKSR PAIHKIDLET VKHIKTISFT NFSCIPENMA YSHLGGYYFV QCKQKGSSSA
SPQLIIDSVT DAIVGPNSDV SGTPYISSDG HYLVSTDEIN GRLKVQTITS QGEMKLVYDV
TTSLYLSDVT FQSSFAEGNQ YYVYATSHLQ TRVLFVDLSS GRVDLVKNLK DPTAQKDWQW
STGNRIIKGS GLFGQYIITP AKDSLFIING RQNLLHCEIS GVQRGNTVVW VGEV
//
