ID F7A7F8_CIOIN Unreviewed; 1060 AA.
AC F7A7F8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCINP00000013790.3};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000013790.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000013790.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the prickle / espinas / testin family.
CC {ECO:0000256|ARBA:ARBA00008268}.
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DR EMBL; EAAA01002615; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F7A7F8; -.
DR STRING; 7719.ENSCINP00000013790; -.
DR Ensembl; ENSCINT00000013790.3; ENSCINP00000013790.3; ENSCING00000006721.3.
DR GeneTree; ENSGT00940000153629; -.
DR HOGENOM; CLU_010525_0_0_1; -.
DR InParanoid; F7A7F8; -.
DR OMA; SDYERWD; -.
DR TreeFam; TF313265; -.
DR Proteomes; UP000008144; Chromosome 8.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd09415; LIM1_Prickle; 1.
DR CDD; cd09418; LIM2_Prickle; 1.
DR CDD; cd09420; LIM3_Prickle; 1.
DR CDD; cd09827; PET_Prickle; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 3.
DR InterPro; IPR033725; LIM1_prickle.
DR InterPro; IPR033726; LIM2_prickle.
DR InterPro; IPR033727; LIM3_prickle.
DR InterPro; IPR010442; PET_domain.
DR InterPro; IPR033723; PET_prickle.
DR InterPro; IPR047120; Pk/Esn/Tes.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24211; LIM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24211:SF20; PROTEIN ESPINAS-RELATED; 1.
DR Pfam; PF00412; LIM; 2.
DR Pfam; PF06297; PET; 1.
DR SMART; SM00132; LIM; 3.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
DR PROSITE; PS51303; PET; 1.
PE 3: Inferred from homology;
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 55..163
FT /note="PET"
FT /evidence="ECO:0000259|PROSITE:PS51303"
FT DOMAIN 165..229
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 230..290
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 878..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1019..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..670
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..774
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1060 AA; 117418 MW; 64BD23419A2D2F31 CRC64;
MTMPAAATEQ TRGTMPSNID PKSAGLDQDI VIRGPTENRV RRRQSRRQAS VRHNRNSASD
EENDGDSGCA LEEYAWVPPN LTPDQVRYYF TSLPEDKVPL VDSIGDKYRV RQLLHQLPPH
DDKVCYCNDL SDEEKRELRL FSEQRKKDYL GCGKIRILPL NTPGTPCSEC GILVKGGDIV
AVASRAEPGM CWHPACFVCS VCRELLVDLF YFYQDGRLYC GRHHAETLKP RCSACDEIIF
SDECTEAEGR HWHMDHFCCF ECDQVLGGQR YIMRDGKPNC TQCFEALYAE YCDMCGDLIG
LDAGQMQYEG QHWHATDNCF CCNRCRKSLL GRPFLPKHGR IFCSKACSLG EDPGHSESDS
QHSSSQYENP QLPTSHNVRR SLNLDNLSIH DKPWEDKGEL SPASNNVFID AADMYPTSAA
VAASTRYSKG HTRPSHPYLD GMDPVNAEMG TENDAGFKGA ATSRKTVTNS VTSPTSTVSS
RTTSKNGVQF PQNTYNSTDS SGYNSSSTLD AIEHQQNAAL KAAMGSNYSY GKSKQTPCSK
RPQNGEDGHV SATEFTPFHP AAPRASPPTI IGSRKLAPEI KKTIDSLTKA TEIDNKSPPV
NVASMLPKSA VPIPAPRARY APSLTPSPPS TAASELTSPW MHKSHARTDS PLDSREFPSP
PVPVPSPPTE SKEHSSPLQR SVSERLANKR RSREPISLPE QTISEHPRLR SDDKHVSVEN
DKTSPELKSI LKKSRNPSKS FRNRERGSLS GSLDRLEEFH RKSDVMKYAS DDEDGAGFGD
AQGDFSSFQR GQRLYSSARF PEEVTEKPRS QNQGGRPRSQ HRTRFKDNSA LDRTHSALNL
DELDCAIARR NPKPGKTCSK LSGKSTCSKK LKRTRSTDFA FERSAATPTS SRKNRRTKRF
VEDEEEDGWC STCTSSSDDS DYERWDGLGT SPPTSPLSAM RRGSAPVGVR VNMTRRQPPH
PFLANADSAL AASAAGFNSN GVYRPSMPRN FHHVAYALQA ETAEKALYRH VTTNAVTKTS
EIDRKSSETK SWRSQDASYL PRGGSKARES APIVDTNTSA
//
