ID F7A7W9_MACMU Unreviewed; 686 AA.
AC F7A7W9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Hook microtubule tethering protein 1 {ECO:0000313|Ensembl:ENSMMUP00000040073.3};
GN Name=HOOK1 {ECO:0000313|Ensembl:ENSMMUP00000040073.3,
GN ECO:0000313|VGNC:VGNC:73424};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000040073.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000040073.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000040073.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the hook family.
CC {ECO:0000256|ARBA:ARBA00006946}.
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DR RefSeq; XP_014996345.1; XM_015140859.1.
DR AlphaFoldDB; F7A7W9; -.
DR SMR; F7A7W9; -.
DR Ensembl; ENSMMUT00000047042.3; ENSMMUP00000040073.3; ENSMMUG00000012850.4.
DR GeneID; 693504; -.
DR KEGG; mcc:693504; -.
DR CTD; 51361; -.
DR VEuPathDB; HostDB:ENSMMUG00000012850; -.
DR VGNC; VGNC:73424; HOOK1.
DR eggNOG; ENOG502QW1T; Eukaryota.
DR GeneTree; ENSGT00940000159251; -.
DR HOGENOM; CLU_011214_3_0_1; -.
DR OrthoDB; 50921at2759; -.
DR Proteomes; UP000006718; Chromosome 1.
DR Bgee; ENSMMUG00000012850; Expressed in spermatid and 21 other cell types or tissues.
DR ExpressionAtlas; F7A7W9; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:InterPro.
DR GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IEA:InterPro.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR008636; Hook_C.
DR InterPro; IPR043936; HOOK_N.
DR PANTHER; PTHR18947; HOOK PROTEINS; 1.
DR PANTHER; PTHR18947:SF36; PROTEIN HOOK HOMOLOG 1; 1.
DR Pfam; PF05622; HOOK; 1.
DR Pfam; PF19047; HOOK_N; 1.
DR SUPFAM; SSF116907; Hook domain; 1.
DR PROSITE; PS50021; CH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 1..86
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT COILED 128..391
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 437..616
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 686 AA; 80096 MW; BB919EE0B92CF4E6 CRC64;
MAQVLHQIDA AWFNESWLSR IKEDVGDNWR IKASNLKKVL QGIMSYYHEF LGQQISEALV
PDLNQITECS DPVELGRLLQ LILGCAINCE KKQEHIQNIM TLEESVQHVV MTAIQELMSK
EILSFPLNDA VGELEQQLKK ALEELQEALA EKEELRQRCE ELDMQVTTLQ DEKNSLVSEN
EMMNEKLDQL DGSFDDPNTV VAKKYFHAQL QLEQLQEENF RLEAAKDDYR VHCEELEKQL
IEFQHRNDEL TSLAEETRAL KDEIDVLRAT SDKANKLEST VEIYRQKLQD LNDLRKQVKT
LQETNMMYMH NTVSLEEELK KANAARTQLE TYKRQVQDLH VKLSSESKRA DTLAFEMKRL
EEKHEALLKE KERLIEQRDT LKETNEELRC SQVQQDHLNQ TGASAAKSYE NLAAEIMPVE
YREVFIRLQH ENKMLRLQQE GSENERIEEL QEQLEQKHRK MNELETEQRL SKERIRELQQ
QIEDLQKSLQ EQGSKSEGES SSKLKQKLEA HMEKLTEVHE ELQKKQELIE DLQPDINQNV
QKINELETAL QKKDEDMKAM EERYKMYLEK ARNVIKTLDP KLNPASAEIM LLRKQLAEKE
RRIEILESEC KVAKFRDYEE KLIVSAWYNK SLAFQKLGME SRLVSGGGAC NDTNACTPAR
SFLAQQRHIT NTRRNLSVKV PATTSD
//
