ID F7A7Y7_XENTR Unreviewed; 455 AA.
AC F7A7Y7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Origin recognition complex subunit 5 {ECO:0000313|Ensembl:ENSXETP00000034808};
GN Name=orc5 {ECO:0000313|Ensembl:ENSXETP00000034808};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000034808};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000034808}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000034808};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000034808}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ORC5 family.
CC {ECO:0000256|ARBA:ARBA00006269}.
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DR AlphaFoldDB; F7A7Y7; -.
DR STRING; 8364.ENSXETP00000034808; -.
DR PaxDb; 8364-ENSXETP00000039737; -.
DR Ensembl; ENSXETT00000034808; ENSXETP00000034808; ENSXETG00000015946.
DR AGR; Xenbase:XB-GENE-954698; -.
DR Xenbase; XB-GENE-954698; orc5.
DR eggNOG; KOG2543; Eukaryota.
DR InParanoid; F7A7Y7; -.
DR TreeFam; TF101095; -.
DR Reactome; R-XTR-176187; Activation of ATR in response to replication stress.
DR Reactome; R-XTR-68616; Assembly of the ORC complex at the origin of replication.
DR Reactome; R-XTR-68689; CDC6 association with the ORC:origin complex.
DR Reactome; R-XTR-68949; Orc1 removal from chromatin.
DR Reactome; R-XTR-68962; Activation of the pre-replicative complex.
DR Bgee; ENSXETG00000015946; Expressed in egg cell and 11 other cell types or tissues.
DR ExpressionAtlas; F7A7Y7; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000808; C:origin recognition complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR020796; ORC5.
DR InterPro; IPR047088; ORC5_C.
DR InterPro; IPR048866; ORC5_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12705; ORIGIN RECOGNITION COMPLEX SUBUNIT 5; 1.
DR PANTHER; PTHR12705:SF0; ORIGIN RECOGNITION COMPLEX SUBUNIT 5; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF14630; ORC5_C; 1.
DR Pfam; PF21639; ORC5_lid; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 46..191
FT /note="Orc1-like AAA ATPase"
FT /evidence="ECO:0000259|Pfam:PF13191"
FT DOMAIN 240..307
FT /note="ORC5 lid"
FT /evidence="ECO:0000259|Pfam:PF21639"
FT DOMAIN 366..451
FT /note="Origin recognition complex subunit 5 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14630"
SQ SEQUENCE 455 AA; 52265 MW; 3EF7B297E71F658A CRC64;
MVRHSLCSRK SGAVGEVALH SAEMSSLAHT AYPEEKLQEV AKLTLCRESQ VSTLLSIFGE
RQHLSFPSIF IYGHTGTGKT YILQTVLSTL ELPCAFINCV ECFTPRLLFE QILNHLHHHH
PAPENEFSSK ERCDTFNDFV RLYNRGMSEL SLQETFYIVL DKAELLREMD ANLLPGFLRL
QELTESNVTV IFLTEIVWET FRPNTGCFEP LTLYFPDYSK VELQKILSSE FPVKYSAEFY
ASYINILLGV FYTVCRDIKE LRHLAALNFP KFCEPVIKGE AKESDSHKLW KNIEPHLKRA
MQTVYLREIS SSQWERIQQE DREASHLKGL SAHAHVELPY YSKFLLIAAY LASFNPARTD
KRFFLKTSNH LLGPKPFPLD RLLAILYSIV DSRVAPTANI FSQISSLVTL QLLTLVGHDD
QLEGPKYKCT VSLDFIRAVA RTVNFDIVRY LYDFL
//
