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Database: UniProt
Entry: F7A885_MONDO
LinkDB: F7A885_MONDO
Original site: F7A885_MONDO 
ID   F7A885_MONDO            Unreviewed;       496 AA.
AC   F7A885;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   24-JAN-2024, entry version 67.
DE   RecName: Full=Fibronectin type III and SPRY domain-containing protein 1 {ECO:0000256|ARBA:ARBA00039546};
GN   Name=FSD1 {ECO:0000313|Ensembl:ENSMODP00000001052.2};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000001052.2, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000001052.2, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA   Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA   Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA   Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA   Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA   Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA   Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA   Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA   VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA   Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA   Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA   Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA   D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA   Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA   Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA   Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA   Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA   Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA   Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA   Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA   Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA   Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA   Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA   Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA   Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA   Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA   Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA   Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA   Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT   coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000001052.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: May be involved in microtubule organization and
CC       stabilization. {ECO:0000256|ARBA:ARBA00037674}.
CC   -!- SUBUNIT: Oligomerization is required for binding to microtubules.
CC       {ECO:0000256|ARBA:ARBA00038555}.
CC   -!- SUBCELLULAR LOCATION: Cleavage furrow {ECO:0000256|ARBA:ARBA00004626}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC       {ECO:0000256|ARBA:ARBA00004300}.
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DR   RefSeq; XP_001374547.2; XM_001374510.4.
DR   AlphaFoldDB; F7A885; -.
DR   STRING; 13616.ENSMODP00000001052; -.
DR   Ensembl; ENSMODT00000001072.3; ENSMODP00000001052.2; ENSMODG00000000881.4.
DR   GeneID; 100022820; -.
DR   KEGG; mdo:100022820; -.
DR   CTD; 79187; -.
DR   eggNOG; KOG2177; Eukaryota.
DR   GeneTree; ENSGT00940000159440; -.
DR   HOGENOM; CLU_013137_19_1_1; -.
DR   InParanoid; F7A885; -.
DR   OMA; TPASWCL; -.
DR   OrthoDB; 5386672at2759; -.
DR   TreeFam; TF333654; -.
DR   Proteomes; UP000002280; Chromosome 3.
DR   Bgee; ENSMODG00000000881; Expressed in spinal cord and 10 other cell types or tissues.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:Ensembl.
DR   GO; GO:0051302; P:regulation of cell division; IBA:GO_Central.
DR   GO; GO:0032465; P:regulation of cytokinesis; IEA:Ensembl.
DR   GO; GO:0060236; P:regulation of mitotic spindle organization; IBA:GO_Central.
DR   CDD; cd00063; FN3; 1.
DR   CDD; cd12901; SPRY_PRY_FSD1; 1.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR003649; Bbox_C.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR017903; COS_domain.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR035742; SPRY/PRY_FSD1.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR24099; E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED; 1.
DR   PANTHER; PTHR24099:SF4; FIBRONECTIN TYPE III AND SPRY DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF00041; fn3; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00502; BBC; 1.
DR   SMART; SM00060; FN3; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS51262; COS; 1.
DR   PROSITE; PS50853; FN3; 1.
PE   4: Predicted;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT   DOMAIN          105..162
FT                   /note="COS"
FT                   /evidence="ECO:0000259|PROSITE:PS51262"
FT   DOMAIN          164..268
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          268..477
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
FT   REGION          302..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          84..111
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   496 AA;  56063 MW;  01B361AF7FBAF0CA CRC64;
     MGDQKEALKK IITTLAVKNE EIQNFIYALK QMLLNVETNS NKVQEDLEAE FQSLFSLLDE
     LKEGMLMKIK QDRASRIYEL QNQLAACTKA LESSEELLET ANQTLQGADN QDFPQAAKQI
     KDSVTMAPAF RLSLKAKVSD NMSHLMVDFA QERRLLQALK FLPVPSAPEI DLAESLVADN
     CVTLVWRMPD EDGKIDHYVL EYRRTNFEGP PRLKEDHPWM VIEGIRQMEY TLSGLKFDMK
     YMNFRVKACN KAVAGEFSEP VTLETTAFMF RLDATTCHQN LRVEELSVEW DAMGGKVQDI
     KAREKDNKGR TASPVNSPAR CAQSPKRMPS GRGGRDRFTA ESYTVLGDTL IDGGEHYWEV
     RYDRDSKAFA VGVAYRSLGR FDQLGKTPAS WCLHLNNWLQ VSFTAKHNNK ARILDVPLPD
     CIGVHCDFDK GVLSFYNART KQLLHTFKAK FNQPLLPAFM VWCGNFQVSS GLQVPSSVRC
     LQKRNSATSS SNASLT
//
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