GenomeNet

Database: UniProt
Entry: F7AAG6_MONDO
LinkDB: F7AAG6_MONDO
Original site: F7AAG6_MONDO 
ID   F7AAG6_MONDO            Unreviewed;       358 AA.
AC   F7AAG6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   24-JAN-2024, entry version 69.
DE   SubName: Full=Homer scaffold protein 3 {ECO:0000313|Ensembl:ENSMODP00000004619.2};
GN   Name=HOMER3 {ECO:0000313|Ensembl:ENSMODP00000004619.2};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000004619.2, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000004619.2, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA   Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA   Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA   Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA   Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA   Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA   Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA   Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA   VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA   Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA   Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA   Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA   D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA   Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA   Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA   Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA   Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA   Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA   Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA   Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA   Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA   Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA   Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA   Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA   Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA   Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA   Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA   Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA   Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT   coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000004619.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Postsynaptic density {ECO:0000256|ARBA:ARBA00034105}. Synapse
CC       {ECO:0000256|ARBA:ARBA00034103}.
CC   -!- SIMILARITY: Belongs to the Homer family.
CC       {ECO:0000256|ARBA:ARBA00023606}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_007489325.1; XM_007489263.2.
DR   RefSeq; XP_007489326.1; XM_007489264.2.
DR   RefSeq; XP_007489327.1; XM_007489265.2.
DR   RefSeq; XP_007489328.1; XM_007489266.2.
DR   RefSeq; XP_007489329.1; XM_007489267.2.
DR   RefSeq; XP_007489330.1; XM_007489268.2.
DR   AlphaFoldDB; F7AAG6; -.
DR   STRING; 13616.ENSMODP00000004619; -.
DR   Ensembl; ENSMODT00000004719.2; ENSMODP00000004619.2; ENSMODG00000003771.4.
DR   GeneID; 100016861; -.
DR   KEGG; mdo:100016861; -.
DR   CTD; 9454; -.
DR   eggNOG; ENOG502R3T0; Eukaryota.
DR   GeneTree; ENSGT00940000158081; -.
DR   HOGENOM; CLU_033940_0_0_1; -.
DR   InParanoid; F7AAG6; -.
DR   OMA; QRCGRWE; -.
DR   OrthoDB; 5490527at2759; -.
DR   TreeFam; TF325627; -.
DR   Proteomes; UP000002280; Chromosome 3.
DR   Bgee; ENSMODG00000003771; Expressed in cerebellum and 18 other cell types or tissues.
DR   GO; GO:0045178; C:basal part of cell; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0014069; C:postsynaptic density; IBA:GO_Central.
DR   GO; GO:0035256; F:G protein-coupled glutamate receptor binding; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR   GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; IEA:Ensembl.
DR   GO; GO:0032703; P:negative regulation of interleukin-2 production; IEA:Ensembl.
DR   GO; GO:2001256; P:regulation of store-operated calcium entry; IBA:GO_Central.
DR   CDD; cd01206; EVH1_Homer_Vesl; 1.
DR   Gene3D; 1.20.5.1700; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR045027; Homer.
DR   InterPro; IPR044100; Homer_EVH1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR000697; WH1/EVH1_dom.
DR   PANTHER; PTHR10918; HOMER; 1.
DR   PANTHER; PTHR10918:SF4; HOMER PROTEIN HOMOLOG 3; 1.
DR   Pfam; PF00568; WH1; 1.
DR   SMART; SM00461; WH1; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50229; WH1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT   DOMAIN          1..112
FT                   /note="WH1"
FT                   /evidence="ECO:0000259|PROSITE:PS50229"
FT   REGION          114..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          195..335
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        126..141
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   358 AA;  40269 MW;  AE56C482186A9955 CRC64;
     MTTREQPLFS TRAHVFQIDP ATKRNWIPAG KHALTVSYFY DATRNVYRII SVGGTKAIIN
     STVTPNMTFT KTSQKFGQWA DSRANTVYGL GFASEQHLSQ FAEKFQEVKE AARLAREKSQ
     DGGELTTPAL GLSSHQVPPS PLIGTNGPGD EKLFRSQSAD GPGPTERERL KKMLSEGSVG
     EVQWEAEFFT LQDNNNKLVA ALREANASVE RWKEQLEAYQ EETERLRLRV AELEAQGPSE
     TPSDGGKEGL SQRLEELEML IKTKDEEIQM LKSQKGGLRE AESEREREEA LQKLQELESR
     YTEMERQLQG TQRSLEEARG ERERARAEVL RATELLDLKI CELSELRQGL ARLADGAP
//
DBGET integrated database retrieval system