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Database: UniProt
Entry: F7AAV9_HORSE
LinkDB: F7AAV9_HORSE
Original site: F7AAV9_HORSE 
ID   F7AAV9_HORSE            Unreviewed;      1912 AA.
AC   F7AAV9;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   20-JUN-2018, entry version 43.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN1A {ECO:0000313|VGNC:VGNC:22732};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000016119, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000016119, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016119,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000016119}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016119};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   Ensembl; ENSECAT00000019680; ENSECAP00000016119; ENSECAG00000015359.
DR   VGNC; VGNC:22732; SCN1A.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000002281; Chromosome 18.
DR   Bgee; ENSECAG00000015359; -.
DR   ExpressionAtlas; F7AAV9; baseline.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    250    270       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    383    410       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    740    764       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    776    797       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    859    887       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    946    972       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1199   1217       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1238   1257       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1313   1341       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1439   1463       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1521   1539       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1551   1569       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1581   1601       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1638   1666       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1742   1765       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      129    417       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      489    698       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      749    976       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      986   1193       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1197   1471       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1520   1775       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      407    452       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1912 AA;  218212 MW;  056B654302276150 CRC64;
     MEQTVLVPPG PDSFNFFTRE SLAAIERRIA EEKAKNPKPD KKDDDENGPK PNSDLEAGKN
     LPFIYGDIPP EMVSALEDLD PYYINKNTFI VLNKGKAIFR FSATSALYIL TPFNPLRKIA
     IKILLHNSMS HMLIMCTILT NCVFMTMSNP PDWTKNVEYT FTGIYTFESL IKIIARGFCL
     EDFTFLRDPW NWLDFTVITF AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL
     IQSVKKLSDV MILTVFCLSV FALIGLQLFM GNLRNKCVQW PPTNASLEEH SIEKNFDWKS
     YIQDSRYHYF LEGFLDALLC GNSSDAGQCP EGYMCVKAGR NPNYGYTSFD TFSWAFLSLF
     RLMTQDFWEN LYQLTLRAAG KTYMIFFVLV IFLGSFYLIN LILAVVAMAY EEQNQATLEE
     AEQKEAEFQQ MLEQLKKQQE AAQQAAAVSA SEHSREPSAV GGLSDSSSEA SKLSSKSAKE
     RRNRRKKRKQ KEQSGGEEKD EDEFHKSESE DSIRRKGFRF SIEGNRLTYE KRYSSPHQSL
     LSIRGSLFSP RRNSRTSLFS FRGRAKDVGS ENDFADDEHS TFEDNESRRD SLFVPRRHGE
     RRNSNLSQTS RSSRMLAVFP ANGKMHSTVD CNGVVSLVVP TSPVGQLLPE VIIDKPATDD
     NGTTTETEMR KRRSSSFHVS MDFLEDPSQR QRAMSIASIL TNTVEELEES RQKCPPCWYK
     FSNIFLIWDC SPYWLKVKHI VNLVVMDPFV DLAITICIVL NTLFMAMEHY PMTEHFNNVL
     TVGNLVFTGI FTAEMFLKII AMDPYYYFQE GWNIFDGFIV TLSLVELGLA NVEGLSVLRS
     FRLLRVFKLA KSWPTLNMLI KIIGNSVGAL GNLTLVLAII VFIFAVVGMQ LFGKSYKDCV
     CKIASDCQLP RWHMNDFFHS FLIVFRVLCG EWIETMWDCM EVAGQAMCLT VFMMVMVIGN
     LVVLNLFLAL LLSSFSADNL AATDDDNEMN NLQIAVDRMH KGIAYVKRKI YEFIQQSFVR
     KQKILDEIKP LDDLNNKKDN CMSNHTAEIG KDLDYLKDVN GTTSGIGTGS SVEKYIIDES
     DYMSFINNPS LTVTVPIAVG ESDFENLNTE DFSSESDLEE SKEKLNESSS SSEGSTVDIG
     APAEEQPVVE PEETLEPEAC FTEGCVQRFK CCQISVEEGR GKQWWNLRRT CFRIVEHNWF
     ETFIVFMILL SSGALAFEDI YIDQRKTIKT MLEYADKVFT YIFILEMLLK WVAYGYQTYF
     TNAWCWLDFL IVDVSLVSLT ANALGYSELG AIKSLRTLRA LRPLRALSRF EGMRVVVNAL
     LGAIPSIMNV LLVCLIFWLI FSIMGVNLFA GKFYHCINTT TGDRFEIEEV NNHSDCLKLI
     ERNETARWKN VKVNFDNVGF GYLSLLQVAT FKGWMDIMYA AVDSRNVELQ PKYEESLYMY
     LYFVIFIIFG SFFTLNLFIG VIIDNFNQQK KKISQDIFMT EEQKKYYNAM KKLGSKKPQK
     PIPRPGNKFQ GMVFDFVTRQ VFDISIMILI CLNMVTMMVE TDDQSEYVTN ILSRINLVFI
     VLFTGECVLK LISLRHYYFT IGWNIFDFVV VILSIVGMFL AELIEKYFVS PTLFRVIRLA
     RIGRILRLIK GAKGIRTLLF ALMMSLPALF NIGLLLFLVM FIYAIFGMSN FAYVKREVGI
     DDMFNFETFG NSMICLFQIT TSAGWDGLLA PILNSKPPDC DPNKVNPGSS VKGDCGNPSV
     GIFFFVSYII ISFLVVVNMY IAVILENFSV ATEESAEPLS EDDFEMFYEV WEKFDPDATQ
     FMEFEKLSQF AAALEPPLNL PQPNKLQLIA MDLPMVSGDR IHCLDILFAF TKRVLGESGE
     MDALRIQMEE RFMASNPSKV SYQPITTTLK RKQEEVSAVI IQRAYRRHLL KR
//
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