ID F7AB14_XENTR Unreviewed; 755 AA.
AC F7AB14;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Proprotein convertase subtilisin/kexin type 7 {ECO:0000313|Ensembl:ENSXETP00000008134, ECO:0000313|RefSeq:XP_002932953.2};
GN Name=pcsk7 {ECO:0000313|Ensembl:ENSXETP00000008134,
GN ECO:0000313|RefSeq:XP_002932953.2, ECO:0000313|RefSeq:XP_004916128.1,
GN ECO:0000313|RefSeq:XP_004916129.1,
GN ECO:0000313|Xenbase:XB-GENE-950061};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000008134};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000008134}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000008134};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000008134}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_002932953.2, ECO:0000313|RefSeq:XP_004916128.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002932953.2,
RC ECO:0000313|RefSeq:XP_004916128.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002932953.2,
RC ECO:0000313|RefSeq:XP_004916128.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240}.
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DR RefSeq; XP_002932953.2; XM_002932907.5.
DR RefSeq; XP_004916128.1; XM_004916071.4.
DR RefSeq; XP_004916129.1; XM_004916072.4.
DR Ensembl; ENSXETT00000008134; ENSXETP00000008134; ENSXETG00000003755.
DR GeneID; 100492320; -.
DR KEGG; xtr:100492320; -.
DR AGR; Xenbase:XB-GENE-950061; -.
DR CTD; 9159; -.
DR Xenbase; XB-GENE-950061; pcsk7.
DR eggNOG; KOG3525; Eukaryota.
DR HOGENOM; CLU_002976_4_3_1; -.
DR OMA; NGRMPFY; -.
DR TreeFam; TF314277; -.
DR Proteomes; UP000008143; Chromosome 7.
DR Bgee; ENSXETG00000003755; Expressed in 4-cell stage embryo and 12 other cell types or tissues.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR PANTHER; PTHR42884:SF28; PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 7; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..755
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041197336"
FT DOMAIN 469..606
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT REGION 184..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..746
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 175
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 216
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 394
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 755 AA; 83445 MW; 16FBACE94A2BE0C7 CRC64;
MYPFPVSSLC LCCYITFVVF HSPPTHAACS LHNMEDVSSG DELTWAVHLD SSGSSGQKEK
MDAFAEQLSR STGLQNRGVI GELKDHYLFA YRGSIQCQED ARRKAHELFT QHEGVRWYSE
QKLLKRSKRS LHFNDPKYPQ QWHLHNARNP GMDINVTGVW ERNVTGRGVT VVVVDDGVQH
TIQDIQPNYS PEGSYDLNSN DPDPMPHPDG GSDNRHGTRC AGEIAAVPNN SFCAVGVAFG
SRIAGIRVLD GPLTDSMEAI AFNKHYQIND IYSCSWGPDD DGKTVDGPHQ LGKAALQHGV
IAGRKGFGSI FVVASGNGGQ FSDNCNYDGY ANSIYTVTIG AVNEAGKMPF YAEECASMLA
VTFSSGDKLM RSIVTSDWNL QKGTGCTEGH TGTSAAAPIA AGMIALMLQV RPCLTWRDIQ
HIIVFTATKY EDRQAAWETN GAGFSHSHQH GFGLLNAWRL TNAAKVWESV PYLASYISPV
FKERKQIPLM PNTLEVYWNV TTADLHLSGM KTLEHVAVTV TIAHPCRGNL EIRLFCPSGM
SSLIGATRRI DMDPNGFSDW TFSTVRCWGE SAEGTYRMVV SDIGDESLRP GVLQQWQLTL
YGSSWSSEDV AERRRVVEDA QSGKFLNSNF SLPCPPGLLI AEQEGYIITN NTLRTLLLLG
CFAVFWSLYY TLELYWSRGP SNGDLDLSCE ESNCSWSCSQ RTPSPQDLEV GSESVPLFGV
EQEEENEVTP PHMYHTSQPG RTRSPTDLRH LTSEL
//
