ID F7AF18_HORSE Unreviewed; 929 AA.
AC F7AF18;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Nucleotide binding oligomerization domain containing 1 {ECO:0000313|Ensembl:ENSECAP00000011590.3};
GN Name=NOD1 {ECO:0000313|Ensembl:ENSECAP00000011590.3,
GN ECO:0000313|VGNC:VGNC:20795};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000011590.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000011590.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000011590.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000011590.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000011590.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004193}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the NOD1-NOD2 family.
CC {ECO:0000256|ARBA:ARBA00038296}.
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DR AlphaFoldDB; F7AF18; -.
DR Ensembl; ENSECAT00000014494.3; ENSECAP00000011590.3; ENSECAG00000013825.4.
DR VGNC; VGNC:20795; NOD1.
DR GeneTree; ENSGT00940000157845; -.
DR HOGENOM; CLU_011291_1_0_1; -.
DR OrthoDB; 3087860at2759; -.
DR TreeFam; TF352118; -.
DR Proteomes; UP000002281; Chromosome 4.
DR Bgee; ENSECAG00000013825; Expressed in articular cartilage of joint and 21 other cell types or tissues.
DR ExpressionAtlas; F7AF18; baseline.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08324; CARD_NOD1_CARD4; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF18; NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13516; LRR_6; 4.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 7.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 15..92
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 196..531
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 929 AA; 104800 MW; 6E2A1C72193CFAE9 CRC64;
MEKQGHREMG IIPSESHSYI KLLKTNRELL VTHIRNTQCL VDNLLKSDYF SAEDAEIVGA
CPTLPDKVRK ILDLVQSKGE EVSEFFLYVL QQLADAYVDL RPWLSEIGFS PSPLIQSKTV
VNTDPVSRYT QKLRHQLGLD SRFILCYAQK EELLLEEMYT DTIMELVGFR NESLGRLGSL
ACLLDHTTGI LSEQGETIFV FGDAGVGKSM LLQRLQGLWA TGQLDAGFKF FFHFRCRMFS
CFRESDVLCL QDLLFKHYCY PEQDPEEVFA FLLRFPHTAL FTFDGLDELH SDFDLSSVPD
TSSPWEPAHP LVLLANLLSG KLLKGASKLL TARTGIEIPR QLLRKKVLLL GFSPSHLRAY
ARRMFPNRAV QDRLLDQLEA NPNLCSLCAV PLFCWIIFRC FQHFHSTFDG SLQLPDCTVT
LTDIFLLVTE VHLNRTQPTS LVQRNMRSQS EAFRAGRDTL HSLGQVAHRG MEKNLFVFGQ
EELQASEMQE GDLQLGFLRA VPELGLGGDQ PSYEFFHLTL QAFFTAFFLV VDDKVGTRGL
LRFFQEWAPP GEAAAASCYP PFLPFQCLGG SGLAGEDPFK NKDHFHFTNL FLCGLLSKTK
QKLLRHLVPG AALRRKRKAL WGHLFASLRS YLKNLPRTQT EGFTQVQAMP TFIWMLRCIY
ETQSEKVGQL AARGICANYL KLTYCNACPA DCSALSFVLH HLRKRLALDL DNNNLNDYGV
RELQPCFSHL TIIRLSVNQI TDSGVKVLHE ELTKYKIVTF LGLYKNQITD VGARYIASIL
DECKGLMYLK LGENKITSEG GKCLALAVKN SKSIFEVGMW GNRIGDEGAK AFAEALRNHP
SLTNLSLAFN GISTEGGKSL AWALQQNTSL RIFWLTKNEL DDEVAESLAE MLKVNQTLKH
LWLIQNQITA KGVAQLVDAL QKNTGIMEI
//
