ID   F7AGI3_ORNAN            Unreviewed;       397 AA.
AC   F7AGI3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=Torsin family 3 member A {ECO:0000313|Ensembl:ENSOANP00000008970.2};
GN   Name=TOR3A {ECO:0000313|Ensembl:ENSOANP00000008970.2};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000008970.2, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000008970.2}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000008970.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC       {ECO:0000256|ARBA:ARBA00004319}.
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family. Torsin subfamily.
CC       {ECO:0000256|ARBA:ARBA00006235}.
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DR   RefSeq; XP_001515683.1; XM_001515633.3.
DR   AlphaFoldDB; F7AGI3; -.
DR   STRING; 9258.ENSOANP00000008970; -.
DR   Ensembl; ENSOANT00000008972.2; ENSOANP00000008970.2; ENSOANG00000005638.2.
DR   GeneID; 100085331; -.
DR   KEGG; oaa:100085331; -.
DR   CTD; 64222; -.
DR   eggNOG; KOG2170; Eukaryota.
DR   GeneTree; ENSGT00950000182888; -.
DR   HOGENOM; CLU_1582247_0_0_1; -.
DR   InParanoid; F7AGI3; -.
DR   OMA; VARMMVF; -.
DR   OrthoDB; 5087at2759; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000005638; Expressed in fibroblast and 8 other cell types or tissues.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; IBA:GO_Central.
DR   GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR049337; TOR1A_C.
DR   InterPro; IPR010448; Torsin.
DR   PANTHER; PTHR10760; TORSIN; 1.
DR   PANTHER; PTHR10760:SF3; TORSIN-3A; 1.
DR   Pfam; PF21376; TOR1A_C; 1.
DR   Pfam; PF06309; Torsin; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..397
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5027966314"
FT   DOMAIN          338..395
FT                   /note="Torsin-1A C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21376"
SQ   SEQUENCE   397 AA;  45758 MW;  07BD59ECE64E0789 CRC64;
     MGLCSPFLLW CYCLLLMLPE TTGHNRREKQ WDGGEQQSTQ SFWADFSGLK KHLKIMTALS
     RRYWAYLSCR VWPQDCKERE KTTSEAPGWK LPLLGQQYLE IFSTWYCRFQ DCCASGDCRI
     INNITGLESD LSIRLHGQHL ARHVVLKAVR DFLALPHPEK ALALSFHGWS GTGKNFVARM
     MADNLYRDGL GSECVKVFIS LFHFPHPRYV DLYQEQLKQH IGETVGRCRQ ALFVFDEAEK
     LHPSLLDTLK LYLHPHHSTK EQDCRRAIFL FLSNLGGNTI NELVLSFLQM GQPREEITLE
     SLEQPLRAEL LASTDSGFGH SSLVKENLID FFVPFLPLEF RHVRLCARDA FEGRGLQYSE
     EALDEIAKMM VYVPKEQKLF SAQGCKSIAQ RINYFLP
//