ID F7AI92_MACMU Unreviewed; 4101 AA.
AC F7AI92;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Dynein axonemal heavy chain 3 {ECO:0000313|Ensembl:ENSMMUP00000022026.4};
GN Name=DNAH3 {ECO:0000313|Ensembl:ENSMMUP00000022026.4,
GN ECO:0000313|VGNC:VGNC:71941};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000022026.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000022026.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000022026.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 9544.ENSMMUP00000022026; -.
DR PaxDb; 9544-ENSMMUP00000022026; -.
DR Ensembl; ENSMMUT00000023543.4; ENSMMUP00000022026.4; ENSMMUG00000016753.4.
DR VEuPathDB; HostDB:ENSMMUG00000016753; -.
DR VGNC; VGNC:71941; DNAH3.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000154959; -.
DR HOGENOM; CLU_000038_7_0_1; -.
DR InParanoid; F7AI92; -.
DR OMA; FFQSCAK; -.
DR TreeFam; TF316836; -.
DR Proteomes; UP000006718; Chromosome 20.
DR Bgee; ENSMMUG00000016753; Expressed in spermatid and 5 other cell types or tissues.
DR GO; GO:0097729; C:9+2 motile cilium; IBA:GO_Central.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961:SF8; DYNEIN AXONEMAL HEAVY CHAIN 3; 1.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 1406..1545
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2051..2198
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 800..837
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2890..2955
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 27..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4101 AA; 469632 MW; 7E201DDA37D2504B CRC64;
MGAAGRLELT LAAPPHLGPA FQPSKVRETQ GEEERSEVQI ARSDSIHHMS HSQGQPELPP
LPASANEEPS GLYQTIMSHS FYPPLMQRTS WTLAAPFKEQ HHHRGPSDSI ANNYSLMAQD
LKLKDLLKVY QPATINVPRD RTGQGLPSSA NKSSSEPIRK KTKFSSRNKE NSTRINLAFK
TSIFSPMKKE GKPSLTFPGS RPMSPEQQLD VMLQQEMEME SKEKKPSESD LERYNYYLTN
GIRKDMIAPE EGEVMVRISN LISNTLLTSP FLEPLMVVLV QEKENDYYSS LMKSIVDYIL
MDPMERKRLF IESIPRLFPQ RVIRAPVPWH SVYRSAKKWN EEHLHTVNPM MLRLKELWFA
EFRDLRFVRT AEILAGKLPL QPQEYWDVIQ KHCLEAHQTL LNKWIPTCAQ LFTSRKEYWV
HFAPKSNYDS CRNIEEYFAS VASFMSLQLR ELVIKSLEDL VSLFMIHEDG NDFKEPYQEM
KFFIPQLIMI KLEVSEPIIV FNPSFDGCWE LIRDSFLEII KNSNGIPKLK YIPLKLSFTA
AAADWQCVQA AELKGYNLIL ETVNAEEKLF SDFLSQTFKV FQKNQVGPRK YLNVYKMYDD
LLDNTAEQNI AAFLKENHDI DDFVMKINAI KKRRNEIASM HITVPLAMFC LDATALNYDL
CERAQNLKEH LIQFQVDVNR DTNTSICNQY SHIADKVSEV PANTKELVFL IEFLKKSSDV
TVFKLRRQLR DASERLEFLM DYADLPHQIE DIFENSRNLL LHKRDQAEMD LIKRCSEFES
RLEGYHRELE GFRKREVMTT EEMKHNVEKL NELSKNLNQA LAEFELINKE EELLEKEKST
YPLLQAMLTN KVPYEQLWST AYEFSTKSEE WMNGPLFLLN AEQIAEEIGN MWRTTYKLVK
TLSDVPAPRR LAENLKIKID KFKQYIPILS ISCNPGMKDR HWQQISEIVG YEIKPTETTC
LSNMLEFGFG KFVEKLEPIG AAASKEYSLE KNLDKMKLDW VNVTFSFVKY RDTDTSILCA
IDDIQMLLDD HVIKTQTMCG SPFVKPIEAE CRKWEEKLIR IQDNLDAWLK CQATWLYLEP
IFSSEDIIAQ MPEEGRKFGI VDSYWKSLMS QAVKDNRVLV AADQPRMAEK LQEANFLLED
IQKGLNNYLE KKRLFFPRFF FLSNDELLEI LSETKDPLRV QPHLKKCFEG IAKLEFIDNL
EIVGMISSEK ETVPFIQKIY PANAKGMVEK WLQQVEQMML ASMREVIGLG IEAYVKVARN
HWVLQWPGQV VICVSSIFWT QEVSQALVEN TLPNFLKKSN DQIAQIVQLV RGKLSSGARL
TLGALTVIDV HARDVVAKLI EDRVSDLNDF QWISQLRYYW VAQDVQVQII TTEALYGYEY
LGNSPRLVIT PLTDRCYRTL MGALKLNLGG APEGPAGTGK TETTKDLAKA LAKQCVVFNC
SDGLDYKAMG KFFKGLAQAG AWACFDEFNR IEVEVLSVVA QQILSIQQAI IRKLKMFIFE
GTELSLNPTC AVFITMNPGY AGRAELPDNL KALFRTVAMM VPDYALIGEI SLYSMGFLDS
RSLAQKIVAT YRLCSEQLSS QHHYDYGMRA VKSVLTAAGN LKLKYPEENE SVLLLRALLD
VNLAKFLAQD VPLFQGIISD LFPGVVLPKP DYEVFLKVLN DNIIKMKLQP VPWFIGKIIQ
IYEMMLVRHG YMIVGDPMGG KTSAYKVLAA ALGDLHAANQ MEEFAVEYKI INPKAITMGQ
LYGCFDQVSH EWTDGVLANA FREQASSLSD DRKWIIFDGP VDAVWIENMN TVLDDNKKLC
LMSGEIIQMN SKMSLIFEPA DLEQASPATV SRCGMIYMEP HQLGWKPLKD SYMDTLPSSL
TEEHKELVND MFMWLVQPCL EFGRLHCKFV VQTSPIHLAF SMMRLYSSLL DEIRAVEEEE
MELGEGLSSQ QIFLWLQGLF LFSLVWTVAG TINADSRKKF DVFFRNLIMG MDDNHPRPKS
VKLTKNNTFP ERGSIYDFYF IKQAGGHWEM WTQYITKEEE KIPAGAKVSE LIIPTMETAR
QSFFLKTYLD HEIPTLFVGP TGTGKSAITN NFLLHLPKNM YLPNCLNFSA RTSANQTQDI
IMSKLDRRRK GLFGPPIGKK AVVFVDDLNM PAKEVYGAQP PIELLRQWID HGYWFDKKDT
TRLDIVDMLL VTAMGPPGGG RNDITGRFTR HMNIVSINAF EDDILTKIFS SIVDWHFGKG
FDVMFLRYGK MLVQATKTIY REAVENFLPT PSKSHYVFNL RDFSRVIQGV LLCPHTHLQD
VEKCIRLWIH EVYRVFYDRL IDKEDRQVFF NMVKETTSNC FKQSVEKVLI HLSPTGKIVD
DNIRSLFFGD YFKPESDKKI YDEITDLKQL TVVMEHYLEE FNNISKAPMS LVMFRFAIEH
ISRICRVLKQ DKGHLLLVGI GGSGRQSATK LSTFMNTYEL YQIEITKNYT GNDWREDLKK
IMLQVGVATK STVFLFADNQ IKDESFVEDI NMLLNTGDVP NIFPADEKAD IVEKMQTAAR
AQGEKVEATP LSMYNFFIER VINKISFSLA MSPIGDAFRN RLRMFPSLIN CCTIDWFQSW
PRDALELVAN KFLEDVELDD NIRIEVVSMC KYFQESVKKL SLDYYNKLRR HNYVTPTSYL
ELILTFKTLL NSKRQEVAMM RNRYLTGLQK LDFAASQVAV MQRELTALQP QLILTSEETA
KMMVKIEAET READAKKLLV QADEKEANVA AAIAQGIKNE CEGDLAEAMP ALEAALAALD
TLNPADISLV KSMQNPPGPV KLVMESICVM KGMKPERKPD PSGSGKMIED YWGVSKKILG
DLKFLESLKT YDKDNIPPLT MKRIRERFIN HPEFQPTVIK NVSSACEGLC KWVRAMEVYD
RVAKVVAPKR ERLREAEGKL DAQMQKLNQK RAELKLVVDR LQALNDDFEE MNTKKKNLEE
NIEICSQKLV RAEKLISGLG GEKDRWTEAA RHLGIRYTNL TGDVLLSSGT VAYLGAFTVD
YRIQCQNQWL AECKDKVIPG SSDFSLSHTL GDPIKIRAWQ IAGLPVDSFS IDNGIIVSNS
RRWALMIDPQ GQANKWIKNM EKANKLAVIK FSDSNYMRML ENALQLGTPV LIENIGEELD
ASIEPILLKA TFKQQGVEYM RLGENIIEYS RDFKLYITTR LRNPHYLPEV AVKVCLLNFM
ITPLGLQDQL LGIVAAKEKP ELEEKKNQLI VESAENKKHL KEIEDKILEV LSMSKGNILE
DETAIKVLSS SKVLSEEISE KQKVASMTET QIDETRMGYK PVAVHSATIF FCISDLANIE
PMYQYSLTWF IHLYMHSLAH STKSEELNLR IEYIIDHFTL SIYNNVCRSL FEKDKLLFSL
LLTIGIMKQK KEITEEVWYF LLTGGVALDN PYPNPAPQWL SEKAWAEIVR ASALPKLHGL
KDHLEQNLDE WKLIYDSAWP HEEQLPGSWK FCQGLEKMVI LRCLRPDKIV PAIREFIAEH
MGKLYIEAPT FDLQGSYNDS SCCAPLIFVL SPSADPMAGL LKFADDLGMG GTRTQTISLG
QGQGPIAARM INNAIKDGTW VVLQNCHLAT SWMPALEKIC EEVIVPESTN ARFRLWLTSY
PSEKFPVSIL QNGIKMTNEP PKGLRANLLR SYLNDPISDP VFFQSCAKAV MWQKMLFGLC
FFHAIVQERR NFGPLGWNIP YEFNESDLRI SMWQIQMFLN DYKEVPFDAL TYLTGECNYG
GRVTDDKDRR LLLSLLSMFY CKEIEEDYYS LAPGDTYYIP PHGSYQSYID YLRSLPITAH
PEVFGLHENA DITKDNQETN QLFEGVLLTL PRQSGGSGKS PQEVVEELAQ DILSKLPKDF
DLEQVMKLYP VVYEESMNTV LRQELIRFNR LTKVVRRSLI DLGRAIKGQV LMSSELEEVF
NSMLVGKVPA MWAAKSYPSL KPLGGYVADL LARLTFFQEW IDKGPPVVFW ISGFYFTQSF
LTGISQNYAR KYTIPIDHIG FEFEVTTQET VMEDNPEDGA YIKGLFLEGA RWDRKMMQIG
ESLPKILYDP LPIIWLKPGE STMFLHQDVY VCPVYKTSAR RGTLSTTGHS TNYVLSIELP
TDRPQKHWIN RGVASLCQLD N
//
