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Database: UniProt
Entry: F7AIU1_CALJA
LinkDB: F7AIU1_CALJA
Original site: F7AIU1_CALJA 
ID   F7AIU1_CALJA            Unreviewed;      4986 AA.
AC   F7AIU1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 2.
DT   18-JUL-2018, entry version 37.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|Ensembl:ENSCJAP00000025194};
GN   Name=RYR1 {ECO:0000313|Ensembl:ENSCJAP00000025194};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000025194, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000025194, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000025194}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
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DR   STRING; 9483.ENSCJAP00000025194; -.
DR   Ensembl; ENSCJAT00000026627; ENSCJAP00000025194; ENSCJAG00000013497.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; F7AIU1; -.
DR   OMA; EMHESIS; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000008225; Unplaced.
DR   GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR   GO; GO:0031674; C:I band; IEA:Ensembl.
DR   GO; GO:0030314; C:junctional membrane complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0006936; P:muscle contraction; IEA:Ensembl.
DR   GO; GO:0043931; P:ossification involved in bone maturation; IEA:Ensembl.
DR   GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl.
DR   GO; GO:0043588; P:skin development; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   PANTHER; PTHR13715:SF15; PTHR13715:SF15; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4298   4315       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4509   4529       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4597   4620       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4786   4808       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4867   4890       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       97    152       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      159    204       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    264       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    327       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      335    392       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      581    797       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1013   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1357   1570       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1869   1923       {ECO:0000256|SAM:Coils}.
FT   COILED     2062   2082       {ECO:0000256|SAM:Coils}.
FT   COILED     2863   2883       {ECO:0000256|SAM:Coils}.
FT   COILED     3321   3341       {ECO:0000256|SAM:Coils}.
FT   COILED     3621   3641       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4986 AA;  559726 MW;  79F79B54593F6342 CRC64;
     MGDAEGEDEV QFLRTDDEVV LQCSATVLKE HLKLCLAAEG FGNRLCFLEP TSNAQNVPPD
     LAICCFVLEQ SLSVRALQEM LANTVEAGVE SSQGGGHRTL LYGHAILLRH AHSCMYLSCL
     TTSRSMTDKL AFDVGLQEDA TGEACWWTMH PASKQRSEGE KVRVGDDIIL VSVSSERYLH
     LSTASGELQV DASFMQTLWN MNPICSRCEE GFVTGGHVLR LFHGHMDECL TISPADSDDQ
     RRLVYYEGGA VCTHARSLWR LEPLRISWSG SHLRWGQPLR VRHVTTGRYL ALTEDQGLVV
     VDASKAHTKA TSFCFRISKE KLDVAPKRDV EGMGPPEIKY GESLCFVQHV ASGLWLTYAA
     PDPKALRLGV LKKKAMLHQE GHMDDALSLT RCQQEESQAA RMIYSTNGLY NQFIKSLDSF
     SGKPRGSGPP AGTALPIEGV ILSLQDLIIY FEPPSEDLKH EEKQSKLRSL RNRQSLFQEE
     GMLSLVLNCI DRLNVYTTAA HFAEFAGEEA AESWKEIVNL LYELLASLIR GNRSNCALFS
     TNLDWLVSKL DRLEASSGIL EVLYCVLIES PEVLNIIQEN HIKSIISLLD KHGRNHKVLD
     VLCSLCVCNG VAVRSNQDLI TENLLPGREL LLQTNLINYV TSIRPNIFVG RAEGTTQYSK
     WYFEVMVDEV IPFLTAQPTH LRVGWALTEG YSPYPGGGEG WGGNGVGDDL YSYGFDGLHL
     WTGHVARLVT SPGQHLLAAE DVVSCCLDLS VPSISFRING CPVQGVFESF NLDGLFFPVV
     SFSAGVKVRF LLGGRHGEFK FLPPPGYAPC HEAVLPRERL HLEPIKEYRR EGPRGPHLVG
     PSRCLSHTDF VPCPVDTVQI VLPPHLERIR EKLAENIHEL WALTRIEQGW TYGPVRDDNK
     RLHPCLVDFH SLPEPERNYN LQMSGETLKT LLALGCHVGM ADEKAEDNLK KTKLPKTYMM
     SNGYKPAPLD LSHVRLTPAQ MTLVDRLAEN GHNVWARDRV GQGWSYSAVQ DIPARRNPRL
     VPYRLLDEAT KRSNRDSLCQ AVRTLLGHGY NVEPPDQEPS QAENQSRWDR VRIFRAEKSY
     AVQSGRWYFE FEAVTTGEMR VGWARPELRP DVELGADELA YVFNGHRGQR WHLGSEPFGR
     PWQPGDVVGC MIDLTENTII FTLNGEVLMS DSGSETAFRE IEIGDGFLPV CSLGPGQVGH
     LNLGQDVSSL RFFAICGLQE GFEPFAINMQ RPVTTWFSKS LPQFEPVPLE HPHYEVSRVD
     GTVDTPPCLR LTHRTWGSQN SLVEMIFLRL SLPVQFHQHF RCTAGATPLA PPGLQPPAED
     EARAAEPDPD YESLRRSAGG WGEAENGKEG TSKEGAPGGT QQAGGEAQPA RAENEKDATT
     EKNKKRGFLF KAKKVAMMTQ PPATPTLPRL PRDVVPADNR DDPEIILNTT TYYYSVRVFA
     GQEPSCVWVG WVTPDYHQHD MSFDLSKVRA VTVTMGDEQG NVHSSLKCSN CYMVWGGDFV
     SPGQQGRISH TDLVIGCLVD LATGLMTFTA NGKESNTFFQ VEPNTKLFPA VFVLPTHQNV
     IQFELGKQKN IMPLSAAMFQ SERKNPAPQC PPRLEMQMLM PVSWSRMPNH FLQVETRRAG
     ERLGWAVQCQ EPLTMMALHI PEENRCMDIL ELSERLDLQR FHSHTLRLYR AVCALGNNRV
     AHALCSHVDQ AQLLHTLEDA RLPGPLRAGY YDLLISIHLE SACRSRRSML SEYIVPLTPE
     TRAITLFPPG RSTENGHPRH GLPGVGVTTS LRPPHHFSPP CFVAALPAAG AAEAPARLSP
     AIPLEALRDK ALRMLGEAVR DGGQHARDPV GGSVEFQFVP VLKLVSTLLV MGVFGDEDVK
     QILKMIEPEV FTEEEEEEEE EEEEEEDEEE KEEDEEEAAH EKEDEEKEEE EAAEGEKEEG
     LEEGLLQMKL PESVKLQMCH LLEYFCDQEL QHRVESLAAF AERYVDKLQD NQRGRYGLLM
     KAFSMTAAET ARRTREFRSP PQEQINMLLH FKDGADEEDC PLPEEIRQDL LDFHQDLLAH
     CGIQLEGEEE EPEEEVTLGS RLMSLLEKVR LVKKKEEKTE EEQPAEESKP RSLQELVSHM
     VVRWAQEDFV QSPELVRAMF SLLHRQYDGL GELLRALPRA YTISLSSVED TMSLLECLGQ
     IRSLLIVQMG PQEENLMIQS IGNIMNNKVF YQHPNLMRAL GMHETVMEVM VNVLGGGESK
     EIRFPKMVTS CCRFLCYFCR ISRQNQRSMF DHLSYLLENS GIGLGMQGST PLDVAAASVI
     DNNELALALQ EQDLEKVVSY LAGCGLQSCP MLVAKGYPDI GWNPCGGERY LDFLRFAVFV
     NGEEGVAAAG QEVWGHRSPH RWGPGRDPLQ WVWGLGHWHL MSAPRPPPIP QLIQAGKGEA
     LRIRAILRSL VPLEDLVGII SLPLQIPTLG KDGALVQPKM SASFVPDHKA SMVLFLDRVY
     GIENQDFLLH VLDVGFLPDM RAAASLDTAT FSTTEMALAL NRYLCLAVLP LITKCAPLFA
     GTEHRAIMVD SMLHTVYRLS RGRSLTKAQR DVIEDCLMAL CRYIRPSMLQ HLLRRLVFDV
     PILNEFAKMP LKLLTNHYER CWKYYCLPTG WANFGVTSEE ELHLTRKLFW GIFDSLAHKK
     YDPELYRMAM PCLCAIAGAL PPDYVDASYS SKAEKKATVD AEGNFDPRPV ETLNVIIPEK
     LDSFINKFAE YTHEKWAFDK IQNNWSYGEN IDEELKTHPM LRPYKTFSEK DKEIYRWPIK
     ESLKAMIAWE WTIEKAREGE EEKTEKKKTR KISQSAQTYD PREGYNPQPP DLSGVTLSRE
     LQAMAEQLAE NYHNTWGRKK KQELEAKGGG THPLLVPYDT LTAKEKARDR EKAQELLKFL
     QMNGYAVTRG LKDMELDSSS IEKRFAFGFL QQLLRWMDIS QEFIAHLEAV VSSGRVEKSP
     HEQEIKFFAK ILLPLINQYF TNHCLYFLST PAKVLGSGGH ASNKEKEMIT SLFCKLAALV
     RHRVSLFGTD APAVVNCLHI LARSLDARTV MKSGPEIVKA GLRSFFESAS EDIEKMVENL
     RLGKVSQART QVKGVGQNLT YTTVALLPVL TTLFQHIAQH QFGDDVILDD VQVSCYRTLC
     SIYSLGTTKN TYVEKLRPAL GECLARLAAA MPVAFLEPQL NEYNACSVYT TKSPRERAIL
     GLPNSVEEMC PDIPVLERLM ADIGGLAESG ARYTEMPHVI EITLPMLCSY LPRWWERGPE
     APPPALPAGA PPPCTAVTSD HLNSLLGNIL RIIVNNLGID EASWMKRLAV FAQPIVSRAR
     PELLQSHFIP TIGRLRKRAG KVVAEEEQLR LEAKAEAEEG ELLVRDEFSV LCRDLYALYP
     LLIRYVDNNR AQWLTEPNPS AEELFRMVGE IFIYWSKSHN FKREEQNFVV QNEINNMSFL
     TADNKSKMAK VGSGGSDQER TKKKRRGDRY SVQTSLIVAT LKKMLPIGLN MCAPTDQDLI
     TLAKTRYALK DTDEEVREFL HNNLHLQGKV EGSPSLRWQM ALYWGVPGRE EDADDPEKIV
     RRVQEVSAVL YHLDQTEHPH KSKKAVWHKL LSKQRRRAVV ACFRMTPLYN LPTHRACNMF
     LESYKAAWIL TEDHSFEDRM IDDLSKAGEQ EEEEEEVEEK KPDPLHQLVL HFSRTALTEK
     SKLDEDYLYM AYADIMAKVS PHTSSGAGLE SLDLPPWVCL PAQEKEMEKQ RLLYQQARLH
     TRGAAEMVLQ MISACKGETG AMVSSTLKLG ISILNGGNAE VQQKMLDYLK DKKEVGFFQS
     IQALMQTCSV LDLNAFERQN KAEGLGMVNE DGTVINRQNG NSPREKVMAD DEFTQDLFRF
     LQLLCEGHNN DFQNYLRTQT GNTTTINIII CTVDYLLRLQ ESISDFYWYY SGKDVIEEQG
     KRNFSKAMSV AKQVFNSLTE YIQGPCTGNQ QSLAHSRLWD AVVGFLHVFA HMMMKLAQDS
     SQIELLKELL DLQKDMVVML LSLLEGNVVN GMIARQMVDM LVESSSNVEM ILKFFDMFLK
     LKDIVGSEAF QDYVTDPRGL ISKKDFQKAM DSQKQFSGPE IQFLLSCSEA DENEMINCEE
     FANRFQEPAR DIGFNVAVLL TNLSEHVPHD PRLHNFLELA ESILEYFRPY LGRIEIMGAS
     RRIERIYFEI SETNRAQWEM PQVKESKRQF IFDVVNEGGE AEKMELFVSF CEDTIFEMQI
     AAQISEPEGE PETDEDEAAA EAGTEGAEEG AAGPEGAAAT AAAGATARVA AAAGRALRGL
     SYRSLRRRVR RLRRLTAREA ATAVATLLWA TVTRAGSAGA GAAAGALGLL WRSLFGGGLV
     EGAKKVTVTE LLAGMPDPTS DEVHGEQPAG PGGDADGEGA GEGAGDAEEG AGDEEEAAHE
     AGPGGADRAV AVTDGGPFRP EGAGGLGDMG DTTPAEPPTP EGSPILKRKL GVDGVEEELP
     PESEPEPEPE PEPEKNGEKE EVPEPPPEPS KKQAPPPPPP KKEEAGGEFW GELEVQRVKF
     LNYLSRNFYT LRFLALFLAF AINFILLFYK VSDSPPGEDD MEGSAAGDVS GAGSGGGSGW
     GLGAGEEAEG DEDESMVYYF LEESTGYMEP ALRCLSLLHT LVAFLCIIGY NCLKVPLVIF
     KREKELARKL EFDGLYITEQ PEDDDVKGQW DRLVLNTPSF PSNYWDKFVK RKVLDKHGDI
     YGRERIAELL GMDLATLEIT AHNERKPNPP PGLLTWIMSI DVKYQIWKFG VIFTDNSFLY
     LGWYMVMSLL GHYNNFFFAA HLLDIAMGVK TLRTILSSVT HNGKQLVMTV GLLAVVVYLY
     TVVAFNFFRK FYNKSEDEDE PDMKCDDMMT CYLFHMYVGV RAGGGIGDEI EDPAGDEYEL
     YRVVFDITFF FFVIVILLAI IQGLIIDAFG ELRDQQEQVK EDMETKCFIC GIGSDYFDTT
     PHGFETHTLE EHNLANYMFF LMYLINKDET EHTGQESYVW KMYQERCWDF FPAGDCFRKQ
     YEDQLS
//
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