ID F7AL00_ORNAN Unreviewed; 1277 AA.
AC F7AL00;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=HMG-box containing 3 {ECO:0000313|Ensembl:ENSOANP00000003626.3};
GN Name=HMGXB3 {ECO:0000313|Ensembl:ENSOANP00000003626.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000003626.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000003626.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000003626.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000003626.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000003626.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7AL00; -.
DR STRING; 9258.ENSOANP00000003626; -.
DR Ensembl; ENSOANT00000003627.3; ENSOANP00000003626.3; ENSOANG00000002292.4.
DR eggNOG; ENOG502QZFJ; Eukaryota.
DR GeneTree; ENSGT00390000006983; -.
DR HOGENOM; CLU_006879_0_0_1; -.
DR TreeFam; TF330893; -.
DR Proteomes; UP000002279; Chromosome X1.
DR Bgee; ENSOANG00000002292; Expressed in cerebellum and 7 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR039598; HMGXB3.
DR InterPro; IPR040648; HMGXB3_CxC4.
DR PANTHER; PTHR17609; HMG DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR17609:SF2; HMG DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF18717; CxC4; 1.
DR Pfam; PF09011; HMG_box_2; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 45..103
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 45..103
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 21..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1277 AA; 138292 MW; 50F99ED735350334 CRC64;
MDAPYDGTEV TVVMEEVEEG YAYTSPGPPK KKKKYKNAGD HGEKAKKPRS AYLLYYYDIY
LKVQQELPHL PQSEINKKIS ESWRLLSVAE KSYYLEKAKL EKEGLDPNTK LSALTAVVPD
IPGFRKILPR SDYIVIPKAT LQEDWSRQPL EPRGARGPGG PKGPPATPAR PREAGASGPG
VAAAEPGVPT EGPAEEGGSF SRADGVREAV ASEILPHYAG AETVSGDVLL DEATLEIGEN
HPYQTSLVIE ETLVSSGGTP DRPDSSPASA HPRDDVSVVA VVRDSEESSA SVPATQFIVL
PLPTHSAAEN PASIKLTTTY TRRGHGNCTN PGCSFTYVTR HKPPKCPTCG NFLGGKWIPK
EKSAKVKVES GPGVSPRTPV AKRGQHPGVP DQGAPQENSS GLTLENSEAV SQLLSVIPVG
EPVQEAEWEE VIISEAHILA STLTSDRCKS ATGATLAGEG GGPRDAAPRP AERESKGPKP
SPLAEGTPAP NPSPLTSAKR TPGADGPPVG PRAQELKSKA RGKPSLLAAA RPMRAILPAP
AGLGRDSGPE APNCSQAFPL NDKASPVRPS GLKPSTLKQL GQSSQQVAGT TDQKGSPSNK
ASQVKVVEVK PDVFPSYKYS CTVTLDLGLA TSRGRGKCKN PSCSYVYTNR HKPRICPSCG
YNLAKDRPEK TAKPLEVSLA PGDALNAAEP LSRAQKEIQH RSTLQLLRKV LQIPENESEL
AEVFALIHEL NSSRLVLSNV SEETVTIEQT SWSNYYESPS TQCLLCSSPL FKGGQNSPAG
PQECWLLTAS RLQLVTAQVK MCLNPRCLAL HSFTDIYTGL FNVGNKLLVS LDLLFAVRNH
IKLGEDPKVS IAGVLDSVQE QTEKTLSPEE LGQLQELLCN GYWAFECLTV RDYNDMICGV
CGVAPKVEVA QRNEANVLAL KNVEFTWPEF LASSEVNVED FWSTMETEVI EQVAFPSGIP
ITKFDASVIA PFFPPLMRGA VVVNTEKDKN PEVQPVPGDG SALVRLLQEG VCRLEQIGSY
GEEELRRLLD QCGVPWRAED TKERLRYSFL ALYESVRNGA GARRPPAHLT GGKIYKVCPH
QVVCGSKYLV RGESARDHVD LLASSRHWPP VYVVDLATPV ALCADLCYPE LTLQMWGKNQ
GCFSSPTEPP MYVSCPELLD RHYTVDTTVA EHPVLHPVTK TTARRIVHAG TEPRGGRRDP
SARHRSLSLC RELEPYAAVL TGDGQSGDAR RRPVTFDNAT HYFLYNRLVD FLTSREIVNR
QIHDVVQSCQ PGEDGGI
//
