ID F7ALC8_MOUSE Unreviewed; 262 AA.
AC F7ALC8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Microtubule-associated protein 2 {ECO:0000313|Ensembl:ENSMUSP00000117996.2};
DE Flags: Fragment;
GN Name=Map2 {ECO:0000313|Ensembl:ENSMUSP00000117996.2,
GN ECO:0000313|MGI:MGI:97175};
GN Synonyms=Mtap2 {ECO:0000313|MGI:MGI:97175};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000117996.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000117996.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117996.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000117996.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117996.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR MaxQB; F7ALC8; -.
DR PeptideAtlas; F7ALC8; -.
DR ProteomicsDB; 347242; -.
DR Antibodypedia; 2169; 1585 antibodies from 47 providers.
DR Ensembl; ENSMUST00000141148.2; ENSMUSP00000117996.2; ENSMUSG00000015222.19.
DR AGR; MGI:97175; -.
DR MGI; MGI:97175; Map2.
DR VEuPathDB; HostDB:ENSMUSG00000015222; -.
DR GeneTree; ENSGT00940000156597; -.
DR HOGENOM; CLU_1067662_0_0_1; -.
DR ChiTaRS; Map2; mouse.
DR Proteomes; UP000000589; Chromosome 1.
DR Bgee; ENSMUSG00000015222; Expressed in anterior amygdaloid area and 218 other cell types or tissues.
DR ExpressionAtlas; F7ALC8; baseline and differential.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR InterPro; IPR027324; MAP2/MAP4/Tau.
DR InterPro; IPR018459; RII-bd_1.
DR PANTHER; PTHR11501; MICROTUBULE-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR11501:SF15; MICROTUBULE-ASSOCIATED PROTEIN 2; 1.
DR Pfam; PF10522; RII_binding_1; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|MaxQB:F7ALC8,
KW ECO:0007829|PeptideAtlas:F7ALC8};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 22..40
FT /note="RII binding"
FT /evidence="ECO:0000259|Pfam:PF10522"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 43..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000117996.2"
FT NON_TER 262
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000117996.2"
SQ SEQUENCE 262 AA; 28575 MW; 9DC2632A97F0BC76 CRC64;
XGTYSDTKEN GINGELTSAD RETAEEVSAR IVQVVTAEAV AVLKGEQEKE AQHKDQPAAL
PLAEETANLP PSPPPSPASE QTATVEEDLL TASKMEFPEQ EKFPSSFAEP LDKGEMEFKM
PSKPGEDFEH AALVPDTSKT PQDKKDLQGM EGEKLPPVPF AQTFGTNLED RKQSTEPSIV
MPSIGLSAEP PAPKEPKDWF IEMPTESKKD EWGLAAPISP GPLTPMREKD VLEDIPRWEG
KQFDSPMPSP FHGGSFTLPL DT
//
