ID F7ANQ4_HORSE Unreviewed; 375 AA.
AC F7ANQ4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Peptidoglycan recognition protein 4 {ECO:0000313|Ensembl:ENSECAP00000009547.2};
GN Name=PGLYRP4 {ECO:0000313|Ensembl:ENSECAP00000009547.2,
GN ECO:0000313|VGNC:VGNC:21357};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000009547.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000009547.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009547.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000009547.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009547.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
CC {ECO:0000256|ARBA:ARBA00007553}.
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DR AlphaFoldDB; F7ANQ4; -.
DR SMR; F7ANQ4; -.
DR STRING; 9796.ENSECAP00000009547; -.
DR PaxDb; 9796-ENSECAP00000009547; -.
DR Ensembl; ENSECAT00000012121.3; ENSECAP00000009547.2; ENSECAG00000011674.3.
DR VGNC; VGNC:21357; PGLYRP4.
DR GeneTree; ENSGT00940000162349; -.
DR HOGENOM; CLU_037559_1_0_1; -.
DR InParanoid; F7ANQ4; -.
DR OMA; AREAHCP; -.
DR OrthoDB; 2282228at2759; -.
DR TreeFam; TF323898; -.
DR Proteomes; UP000002281; Chromosome 5.
DR Bgee; ENSECAG00000011674; Expressed in zone of skin and 1 other cell type or tissue.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0008745; F:N-acetylmuramoyl-L-alanine amidase activity; IEA:InterPro.
DR GO; GO:0042834; F:peptidoglycan binding; IEA:Ensembl.
DR GO; GO:0016019; F:peptidoglycan immune receptor activity; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IEA:Ensembl.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR GO; GO:0016045; P:detection of bacterium; IEA:Ensembl.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:Ensembl.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR CDD; cd06583; PGRP; 2.
DR Gene3D; 3.40.80.10; Peptidoglycan recognition protein-like; 2.
DR InterPro; IPR036505; Amidase/PGRP_sf.
DR InterPro; IPR002502; Amidase_domain.
DR InterPro; IPR015510; PGRP.
DR InterPro; IPR006619; PGRP_domain_met/bac.
DR PANTHER; PTHR11022; PEPTIDOGLYCAN RECOGNITION PROTEIN; 1.
DR PANTHER; PTHR11022:SF12; PEPTIDOGLYCAN RECOGNITION PROTEIN 3; 1.
DR Pfam; PF01510; Amidase_2; 2.
DR SMART; SM00644; Ami_2; 2.
DR SMART; SM00701; PGRP; 2.
DR SUPFAM; SSF55846; N-acetylmuramoyl-L-alanine amidase-like; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..375
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018673387"
FT DOMAIN 55..197
FT /note="Peptidoglycan recognition protein family"
FT /evidence="ECO:0000259|SMART:SM00701"
FT DOMAIN 66..214
FT /note="N-acetylmuramoyl-L-alanine amidase"
FT /evidence="ECO:0000259|SMART:SM00644"
FT DOMAIN 213..354
FT /note="Peptidoglycan recognition protein family"
FT /evidence="ECO:0000259|SMART:SM00701"
FT DOMAIN 223..360
FT /note="N-acetylmuramoyl-L-alanine amidase"
FT /evidence="ECO:0000259|SMART:SM00644"
SQ SEQUENCE 375 AA; 41218 MW; 8F1A8C67F2C49A2D CRC64;
MLLWLRVFSV LGLGVWGDSP WDATRAKRMS EGLRYLFGNI TQLIEKGKLG VNDISTVVSR
KEWGVEAVGC GTHLTSPVNF LVTHHVPGLE CHNQTVCSQR LRELQAHHVH NNSWCDVAYN
FLVGDDGRVY EGIGWDIQGM HTQGYNNISL GFAFFGTKEG HSPSPAALSA MEGLISSAVR
KGHLSSLYVQ PLLVKGEDCL APLQKASPKK ACPYIVPRSD WEARETHCPK MNLPAKYVII
IHTSGRVCNM SDECRLLVQD IQSLLMDRFN SCDIGYNFLV GQDGVLYEGV GWNVQGSHTA
GYNDIALGIA FMGTFSGTPP NAAALEAAQN LIQCAVDEGY LDPNYLLVAQ SDLIKTLSPG
QALYNIISSW PHFKH
//
