ID F7APS7_HORSE Unreviewed; 630 AA.
AC F7APS7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=TNF receptor superfamily member 8 {ECO:0000313|Ensembl:ENSECAP00000011838.3};
GN Name=TNFRSF8 {ECO:0000313|Ensembl:ENSECAP00000011838.3,
GN ECO:0000313|VGNC:VGNC:24373};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000011838.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000011838.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000011838.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000011838.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000011838.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR AlphaFoldDB; F7APS7; -.
DR STRING; 9796.ENSECAP00000011838; -.
DR PaxDb; 9796-ENSECAP00000011838; -.
DR Ensembl; ENSECAT00000014792.4; ENSECAP00000011838.3; ENSECAG00000014108.4.
DR VGNC; VGNC:24373; TNFRSF8.
DR GeneTree; ENSGT00510000049215; -.
DR HOGENOM; CLU_043282_0_0_1; -.
DR InParanoid; F7APS7; -.
DR OMA; CKACVTC; -.
DR TreeFam; TF331157; -.
DR Proteomes; UP000002281; Chromosome 2.
DR Bgee; ENSECAG00000014108; Expressed in chorionic villus and 13 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0032759; P:positive regulation of TRAIL production; IEA:Ensembl.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13409; TNFRSF8; 2.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR020416; TNFR_8.
DR InterPro; IPR034002; TNFRSF8_N.
DR PANTHER; PTHR47497; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 8; 1.
DR PANTHER; PTHR47497:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 8; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR PRINTS; PR01923; TNFACTORR8.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 132..174
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 132..174
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REPEAT 266..304
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 266..304
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REGION 171..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 156..174
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 630 AA; 66873 MW; 1F8E1288218F507A CRC64;
MRSLRAALGL LLLGVLQALP QGQAPTDPCA GDPSRYHDEA AGKCCYRCPG GPTPQPLCPQ
NSSDCPKQCE PDYYLSAHGR CTACVSCAGG KRLVLSPRAH SRQGLLRGQA ESLEDDLVEK
KPCSWNSPRV CECRAGMFCA TSATNSCARC FPHSDCPPGM IVKFQGTAEK DTICEPPSPR
ASPDCSTSPE DCEAPASDST LQAKPALTSP ARSDARTMLL GGGTPEEDSK MTRAPNSPSS
VGKPSPDLGP TPQQPCPQGS ADCRKQCEPD YYLERDGRCT ACVSCAGDDL VEKTPCTWNS
SRVCECRPGM FCATSATNSC ARCVARPICP PGMVTKLQGA AERDTTDNPP PPGSHPNCST
NPEDREASAS STPSLADPQT SMGPGGGITH AWGDASILTS APISFSSTGK PMLVSGPVLF
WVIMTLVVVV GSSSFLLCHR RACRKWIRQK LHLCYPVRTF RPKLEPGLVD SRPRRKSPEL
RRSVSLAEPG MAELGLMSSP SPAVETCPSV GAAGQETLRL LEASPASRPS SPTGPPEPRV
TTEHTNNRIE KIYIMKADTV IVGTVKTEVP EGRGLVGPAG PEFEEDLEVD HAPHYPEQET
EPPLGSCGDV MFSVEEEGKE DPLPTTASGK
//
