ID F7AQC6_HORSE Unreviewed; 625 AA.
AC F7AQC6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 6 {ECO:0000256|ARBA:ARBA00020973, ECO:0000256|RuleBase:RU365075};
DE Short=COG complex subunit 6 {ECO:0000256|RuleBase:RU365075};
DE AltName: Full=Component of oligomeric Golgi complex 6 {ECO:0000256|ARBA:ARBA00031348, ECO:0000256|RuleBase:RU365075};
GN Name=COG6 {ECO:0000313|Ensembl:ENSECAP00000009223.3,
GN ECO:0000313|VGNC:VGNC:16717};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000009223.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000009223.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009223.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000009223.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009223.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Required for normal Golgi function.
CC {ECO:0000256|ARBA:ARBA00003627, ECO:0000256|RuleBase:RU365075}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000256|ARBA:ARBA00011166}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004395, ECO:0000256|RuleBase:RU365075};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004395,
CC ECO:0000256|RuleBase:RU365075}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000256|ARBA:ARBA00011023,
CC ECO:0000256|RuleBase:RU365075}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7AQC6; -.
DR Ensembl; ENSECAT00000011756.3; ENSECAP00000009223.3; ENSECAG00000010790.4.
DR VGNC; VGNC:16717; COG6.
DR GeneTree; ENSGT00390000013518; -.
DR TreeFam; TF314527; -.
DR Proteomes; UP000002281; Chromosome 17.
DR Bgee; ENSECAG00000010790; Expressed in gluteus medius and 23 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR010490; COG6.
DR InterPro; IPR048369; COG6_C.
DR InterPro; IPR048368; COG6_N.
DR PANTHER; PTHR21506; COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6; 1.
DR PANTHER; PTHR21506:SF0; CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6; 1.
DR Pfam; PF20653; COG6_C; 1.
DR Pfam; PF06419; COG6_N; 1.
DR SMART; SM01087; COG6; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU365075};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365075};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU365075};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365075}.
FT DOMAIN 60..172
FT /note="Conserved oligomeric complex COG6 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06419"
FT DOMAIN 205..613
FT /note="Conserved Oligomeric Golgi complex subunit 6 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF20653"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 625 AA; 69739 MW; D931BCBBA23607D1 CRC64;
MAEGSGEVVA VPPSGAANGL SNGAGGTSAQ SSNPLSRKLH KILETRLDND KEMLEALKAL
SSFFVENSLR TRRNLRGDIE RRSLAINEEF VSIFKEVKEE LESINEDVQA MSNCCQDMTS
RLQAAKEQTQ DLIVKTTKLQ AESQRLEIRA QVADAFLSKF QLTSDEMSLL RGTREGPITE
DFFKALGRVK QIHNDVKVLL RTNQQTAGLE IMEQMALLQE TAYERLYRWA QNECRTLTQE
SCDISPVLTK AMEALQDRPV LYKYTLDEFG TARRSTVVRG FIDALTRGGP GGTPRPIEMH
SHDPLRYVGD MLAWLHQATA SEKEHLEALL KHVTTQGVEE NIQEVVGHIT EGVCRPLKVR
IEQVIVAEPG AVLLYKISNL LKFYHHTISG IVGNSATTLL TTIEEMHLLS KKIFFNSLSL
HASKLMDKVE LPPPDLGPSS ALNQTLMLLR EVLASHDSSV VPLDARQADF VQVLSCVLDP
LLQMCTVSAS NLGTADMATF MVNSLYMMKT TLALFEFTDR RLEMLQFQIE AHLDTLINEQ
ASYVLTRTGL SYIYNTVQQH KPEQGPLANL PNLDSVALKA AMVQFDRYLS APDNLLMPQL
NFLLSATVKE QFISYSEICS LDKFG
//
