ID F7ASN6_CIOIN Unreviewed; 317 AA.
AC F7ASN6; A0A1W2W4V6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=GDP-L-fucose synthase {ECO:0000256|ARBA:ARBA00012371};
DE EC=1.1.1.271 {ECO:0000256|ARBA:ARBA00012371};
DE AltName: Full=GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase {ECO:0000256|ARBA:ARBA00032995};
GN Name=LOC100180068 {ECO:0000313|Ensembl:ENSCINP00000011654.3};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000011654.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000011654.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the two-step NADP-dependent conversion of GDP-4-
CC dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a
CC reductase reaction. {ECO:0000256|ARBA:ARBA00002870}.
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via
CC de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.
CC {ECO:0000256|ARBA:ARBA00004883}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. Fucose synthase subfamily. {ECO:0000256|ARBA:ARBA00005959}.
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DR EMBL; EAAA01000294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002124066.1; XM_002124030.4.
DR AlphaFoldDB; F7ASN6; -.
DR STRING; 7719.ENSCINP00000011654; -.
DR Ensembl; ENSCINT00000011654.3; ENSCINP00000011654.3; ENSCING00000005624.3.
DR GeneID; 100180068; -.
DR KEGG; cin:100180068; -.
DR GeneTree; ENSGT00390000004681; -.
DR HOGENOM; CLU_007383_18_2_1; -.
DR InParanoid; F7ASN6; -.
DR OMA; FMYAGDL; -.
DR OrthoDB; 5474548at2759; -.
DR TreeFam; TF314936; -.
DR UniPathway; UPA00128; UER00191.
DR Proteomes; UP000008144; Chromosome 1.
DR GO; GO:0050577; F:GDP-L-fucose synthase activity; IBA:GO_Central.
DR GO; GO:0042351; P:'de novo' GDP-L-fucose biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05239; GDP_FS_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR HAMAP; MF_00956; GDP_fucose_synth; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR028614; GDP_fucose/colitose_synth.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43238; GDP-L-FUCOSE SYNTHASE; 1.
DR PANTHER; PTHR43238:SF1; GDP-L-FUCOSE SYNTHASE; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 7..241
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 317 AA; 35906 MW; DCD449F09DBAE589 CRC64;
MATQKRILVT GGSGLVGQGI KAASEADKRS DEEFIYLCSK DADLTDREAT KAVFKKHQPT
HVIHLAAKVG GLYGNMRANL QFFRINSAIN DNILSVAQEM GVKKVVSCLS TCIFPNETTY
PIDETMIHNG PPHDSNYGYS YAKRMIDVMN KGFNQQYDTE FTAVVPTNVF GPFDNFNLEE
GHVMPGLIHK VYKCKENNTP LTVWGTGRAR RQFIYSKDLG RLFLWVLREY KETEPIILSV
GEEDEISIKE AAEFVAKGFD FKGDFVYDTT RSDGQYKKTA SNAKLRKYLP DFKFTPMDQA
IRETCEWFTA NYSTARI
//
