ID F7AYR0_MONDO Unreviewed; 2125 AA.
AC F7AYR0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=MAM and LDL receptor class A domain containing 1 {ECO:0000313|Ensembl:ENSMODP00000011798.4};
GN Name=MALRD1 {ECO:0000313|Ensembl:ENSMODP00000011798.4};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000011798.4, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000011798.4, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000011798.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_007504963.1; XM_007504901.1.
DR STRING; 13616.ENSMODP00000011798; -.
DR Ensembl; ENSMODT00000012021.4; ENSMODP00000011798.4; ENSMODG00000009440.4.
DR CTD; 340895; -.
DR eggNOG; KOG1095; Eukaryota.
DR GeneTree; ENSGT00940000158809; -.
DR HOGENOM; CLU_002270_0_0_1; -.
DR InParanoid; F7AYR0; -.
DR OMA; YMGDVVI; -.
DR OrthoDB; 2905895at2759; -.
DR TreeFam; TF330345; -.
DR Proteomes; UP000002280; Chromosome 8.
DR Bgee; ENSMODG00000009440; Expressed in kidney and 6 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR GO; GO:0070858; P:negative regulation of bile acid biosynthetic process; IEA:Ensembl.
DR CDD; cd00112; LDLa; 10.
DR CDD; cd06263; MAM; 8.
DR Gene3D; 2.60.120.200; -; 9.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 10.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR000998; MAM_dom.
DR PANTHER; PTHR23282; APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR; 1.
DR PANTHER; PTHR23282:SF146; ENDOSOMAL GLYCOPROTEIN PRECURSOR, PUTATIVE-RELATED; 1.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF00629; MAM; 9.
DR PRINTS; PR00261; LDLRECEPTOR.
DR PRINTS; PR00020; MAMDOMAIN.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00192; LDLa; 10.
DR SMART; SM00137; MAM; 8.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 9.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 9.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01209; LDLRA_1; 7.
DR PROSITE; PS50068; LDLRA_2; 10.
DR PROSITE; PS50060; MAM_2; 9.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2033..2058
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..140
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 185..340
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 387..550
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 610..774
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 821..982
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 1046..1214
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 1263..1423
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 1477..1635
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 1686..1851
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 1982..2016
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 347..359
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 354..372
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 574..586
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 581..599
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 593..608
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 802..817
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1028..1043
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1222..1234
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1229..1247
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1441..1453
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1448..1466
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1460..1475
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1651..1669
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1663..1678
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1882..1897
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1906..1918
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1913..1931
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1925..1940
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2006..2015
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2125 AA; 237054 MW; D2C8CBACFF69F79C CRC64;
MGWTKKNGIT STSPPYQNHN GNESAYFLSL ASKTGSSPAN IKSRVFHPTN SQRSCQVTFY
HYASHVKIKI SVGLQTMCGN SFQTIWQSSA GSPNRWERNT IKINSTQKFQ VVIQGQRFST
DGEEEALAID DISFSEGCQP DLSKNSLCQE TLNTCDWTHQ QDASLCNYES SFDLESANEK
SCFCQFCGFE FDTCGWSSAK SATEISWVRT KAREKLGFKS TPPKDHGGDI EGHYMWVGAD
NDTFSRSAYL NSSKCQCFGK SCHLRFYYSM ADSILTVGLY NDKEKEILWT SDASTMGEWM
KMDVSVPETI TTFKFVFEGT VQNREGFIGL DSLQVYSCEE THEPSPCPVE EFSCASGQCI
PSGLECDYQQ DCSDQSDEDP SACSNYTLCN FESGFCDWKP LWTKESHWKI SKGLSPRGFE
LPHADHTTNS EYGSFIYFGA DLLPGVSHLG SPLLTSLNPT SAPCQVRFWY HLSQNSQLSV
FTRTSLDDEL QKQSDFLEVS KSQWTRANIS VYPMSGKLFL PFQVILQATI FSENATVAID
DISINPDCGL FFASLSNIPI KNKGKEIVAQ TGGCEAGFVP CEDASCILSS KVCDFTPDCP
NGMDEAHCAT SCDFEIDSCG WFEAHGGDHF DWVRNSSITL SVDVQQQAPA QDHTYNKPQG
HFMFILKTSR SISQVAKLQS PRFSQTGPGC SLSFWFYNYG DSVGAAEMQL HLEGTNYSTA
LWRVLYNQGN QWSKAFIQLG RINQPFYLTL EKVSLGIYNG VSAIDDIRFE NCALPLPTVS
CEGPDYFWCR QTKVCIDRLL LCDLVDNCGD ATDEANCTPE NSCDFENGLC NWEQDKEDDF
DWTRNQGETS TLNTGPMKDN TLGTVKGHYL YIESSEPQVF QNRAVLLSPL LNGTNNKSCI
FRFHYHMFGK HIYRLVIYQR IWSNTRGHVL WQIFGNQGNR WKRKALNITS TQPFQILVEA
SVGDGFTGDI AIDDLSFMDC ALYPGNLPEN FIPPSGTLIP VTLPPHNCTD DEFVCRSNGH
CIEKIQKCDF RSDCPDQSDE ASCVMEVCSF EDGNLCKWYQ PELMERSQAI NTFRWDLGNG
ASIHHGEENH RPSVDHTKNS TDGYYLYADS SNGKFGHISD IITPVISLTG PKCSLVFWNH
MNGATIGSLQ VLIKKDNVTS KLWAQTGQQG AQWKRVEVFL GIHSNIQIIF RAKRGVSYMG
DVAVDDIAFQ DCSPLVISEK KCTAQEFLCA NKYCISKDNL CDFVNDCADN SDENPFICGI
SIGRCDFEFD LCFWEQSQKD DLDWNLKAAI TPTTGTEPVA DHTFQDPSGH YIFIKSLFPQ
QPMREAHLST PMISRRSKNC KIIFHYHMYG KGIETLTVSQ ISVTNNTKVL FHLSGGQDNF
WKRKELILQS EEDFQVIFEG RVGKGHRGHI ALDDIVLSKG CFPSHQTIVK EPIALLMSDS
CPHGYRRCQN GKCFRPEQSC NFVDDCGDNT DENECGTSCT FENGSCGWQN SLADNFDWVL
GVGSLLLLSP SRDHTALGNA TGHFLHLEAT PVGLRGEKAH LKSSQWQESS TACVLTFWYF
ISTKATGSIQ VLVKTEKGLS KVWTEEGQNP DNQWKKAEIL LGKLRNFEVI FEGIRTRDLG
GGAAIDDIEF KNCSIAGENS EMCPEATDFM CQDKKCIEHH LVCDYKPDCM DSSDEAYCSQ
YTSIPGSCNF ENAPHNWTSA CHLTQDTQDN LYWNVGNRIT TERESLDSDH TPGNGQYFLY
VNSTGPKEGY TARITTTHFF PASLGICTVR FWIYISGSSD MGILKVYIVE ESGLEILVWS
MIGNNGRDWM YGNVPLSSNG PFKVTFEADL GGDNLTFIAL DDISFTLECK SGGPVTTLPP
PCEAHQFPCV YTPQCVSLSG KCNGQEDCMD GTDELDCPTG SPPQPCRKLE FQCSTNECIP
SLLLCDGVPD CQFNEDESTC SGGHCMDGSL MCPSTNSCIP ASQRCDGFVD CTDFQLDESS
CSECPIGYCK NGGTCIIEKN MPICRCISEW RGNRCHIPLS SASPAEVIFT QNGIWTILII
GLTFLTTHLA IALFSFLYNR KQPRKKPEET AYAFANPMYE DGNCSEKTEA TGSTVFPRIQ
ISVSPWQAHT ETSAYSFANP LYGAT
//
