ID F7B0K4_HORSE Unreviewed; 558 AA.
AC F7B0K4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Mucin 13, cell surface associated {ECO:0008006|Google:ProtNLM};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000004673.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000004673.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000004673.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000004673.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000004673.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_014588331.1; XM_014732845.1.
DR AlphaFoldDB; F7B0K4; -.
DR STRING; 9796.ENSECAP00000004673; -.
DR PaxDb; 9796-ENSECAP00000004673; -.
DR Ensembl; ENSECAT00000006568.4; ENSECAP00000004673.4; ENSECAG00000006569.4.
DR GeneTree; ENSGT00940000154419; -.
DR HOGENOM; CLU_020534_0_0_1; -.
DR InParanoid; F7B0K4; -.
DR OMA; HKQCLIK; -.
DR Proteomes; UP000002281; Chromosome 19.
DR Bgee; ENSECAG00000006569; Expressed in endometrium and 2 other cell types or tissues.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000082; SEA_dom.
DR PANTHER; PTHR24037; HEART DEVELOPMENT PROTEIN WITH EGF-LIKE DOMAINS 1; 1.
DR PANTHER; PTHR24037:SF10; MUCIN-13; 1.
DR Pfam; PF01390; SEA; 1.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00200; SEA; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50024; SEA; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..558
FT /note="Mucin 13, cell surface associated"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040442857"
FT TRANSMEM 461..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 211..249
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 250..374
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT REGION 27..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 558 AA; 58384 MW; B4D21CC4263C0E56 CRC64;
MKGFTPLILL TLLFVTSVTS QSSTNVSSTL ASSTSHPPDT TGVTTNTTTG PTTGVTTNAT
ADPTTGVTTN ATAGPTIGVT TNATAGPTTG VTTNATADPT IGVTTNATAG PTTVSVTTTP
INNSSSVEDT TESTTSANTL TTVAAVTTPA VSSSSVDSVT TVPSLTTQTN DGSSPTTVTG
GGVSSGTVSS VTFSHVTSSE NITPKPSTTG PSGPCQGDPC SGGSSCVSLN SHYFCLCPEG
YYYNSSLCNK GKVFPGTVTV RVSGTSDLES QQSAAYQDLY NKITTFFADA FSSSDYGQTV
ILKVSTSPSA RSEMRAGEQD INVSVVNIFV QTTKENETSV SDTIQKAIAD ASGDIRTYAR
QERCDYYGCQ KTDAQDDCSS GVLCTCKEGL TRPNLQVPFC LASGAQCPDT CNAEHKRQCF
VKSDGSTGCD CLPGYKQDGQ GTCQECAFGF SGVNCEDNFK LILTIVGVIA GILILSMAIT
LIISARSRNK QKNIEEQNLI DNEFQNLRLQ QTTGFSNPGA DRSLFPKVRT NISRDDQLQN
PYANQRGSHN PYTNRREW
//
