ID F7B1X0_HORSE Unreviewed; 2029 AA.
AC F7B1X0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Dedicator of cytokinesis 11 {ECO:0000313|Ensembl:ENSECAP00000016331.3};
GN Name=DOCK11 {ECO:0000313|Ensembl:ENSECAP00000016331.3,
GN ECO:0000313|VGNC:VGNC:17264};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000016331.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000016331.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016331.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000016331.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016331.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR Ensembl; ENSECAT00000019915.4; ENSECAP00000016331.3; ENSECAG00000020337.5.
DR VGNC; VGNC:17264; DOCK11.
DR GeneTree; ENSGT00940000155658; -.
DR HOGENOM; CLU_000624_1_0_1; -.
DR Proteomes; UP000002281; Chromosome X.
DR Bgee; ENSECAG00000020337; Expressed in blood and 23 other cell types or tissues.
DR ExpressionAtlas; F7B1X0; baseline.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11700; DHR2_DOCK11; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF81; DEDICATOR OF CYTOKINESIS PROTEIN 11; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 192..227
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 595..773
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1564..1991
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1203..1222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1207..1222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2029 AA; 232661 MW; 1659C22A5F2B1293 CRC64;
MAEVRKFTKR LSKPGTAAEL RQSVSEAVRG SVVLEKTKVV EPLDYENVIT QRKTQIYSDP
LRDLLMFPME DISISVISRQ RRTVQSTVPE DGEKRAQSLF VKECIKTYST DWHVVNYKYE
DFSGDFRMLP CKSLRPEKIP NHVFEIDEDC EKDEDSSSLC SQKGGVIKQG WLHKANVNST
ISVTMKCPKM RRHAFELKML DKYSHYLAAE TEQEMEEWLI TLKKIIQINT DSLVQEKKET
VETAQDDETS SQGKAENIMA SLERSMHPEL MKYGRETEQL NKLSRGDGRQ NLFSFDSEVQ
RLDFSGIEPD IKPFEEKCNK RFLVNCHDLT FNILSQVGDN AKGPPTNVEP FFINLALFDV
KNNCKISADF HVDLNPPSVR EMLWGASTHL AGDGNLKGSS PESFVHGIAE SQLRYIKQGI
FSVTNPHPEM FLVARIEKVL QGNIAHCAEP YIKNSDPAKT AQKVHRTAKQ VCSRLGQYRM
PFAWAARPIF KDNQGSLDLD GRFSPLYKQD SSKLSNEDIL KLLSEYKKPE KTKLQIIPGQ
LNITVECVPV DLSNCITSSY VPLKPFEKNC QNITVEIEEF VPEVTKYCYP FTIYKNHLYV
YPLQLKYDSQ KTFAKARNIA VCLEFRDSDE SDASALKCIY GKPAGPVFTT NAYAVVSHHN
QNPEFYDEIK IELPIHLHHK HHLLFTFYHV SCEISTKGTT KKQDTVETPV GFAWVPLLKD
GRIITFEQQL PVSANLPPGY LNLNDAESRR QSNVDVKWVD GAKPLLKIKS HLESTIYTQD
LHVHKFFHHC QLIQSGSKEV PGELIKYLKC LHAMEIQVMI QFLPVILMQL FRVLTNMTHE
DEVPINCTMV LLHIVSKCHE EGLDNYLRSF IKYSFRPEKP SAPQAQLIHE TLATTMIAIL
KQSVDFLAVN KLLKYSWFFF EIIAKSMATY LLEENKIKLP RGQRFPEAYH HVLHSLLLAT
IPHVTIRYVE IPDESRNVNY SLANFLKRCL TLMDRGFVFN LINDYISGFS PKDPKVLAEY
KFEFLQTICN HEHYIPLNLP MAFAKPKLQR VQDSNLEYSL SDEYCKHHFL VGLLLRETSI
ALQDNYEIRY TAISVIKNLL IKHAFDTRYQ HKNQQAKIAQ LYLPFVGLLL ENIQRLAGRD
TLYSCAAMPN SASRDEFACG FTSPTNRGSL STDKDTAYGS FQNGHGIKRE DSRGSLIPEG
VIGFPDQGST GENTRQSSTR SSVSQYNRLD QYEIRSLLMC YLYIVKMISE DTLLTYWNKV
SPQELINILV LLEVCLFHFR YMGKRNIARV HDAWLSKHFG VDRKSQTMPA LRNRSGVMQA
RLQHLSSLES SFTLNHSSTT TEADIFHQAL LEGNTATEVA LTVLDTISFF TQCFKNQLLN
NDGHNPLMKK VFDIHLAFLK NGQSEVSLKH VFASLRAFIS KFPSAFFKGR VNMCAAFCYE
VLKCCTSKIS STRNEASALL YLLMRNNFEY TKRKTFLRTH LQIIIAVSQL IADVALSGGS
RFQESLFIIN NFANSDRPMK ATAFPTEVKD LTKRIRTVLM ATAQMKEHEK DPEMLIDLQY
SLAKSYASTP ELRKTWLDSM AKIHIKNGDF SEAAMCYVHV AALVAEFLHR KKLFSNGCSA
FKKITPNIDE EAAMKEDAGM MDVHYSEEVL LELLEQCVDG LWKAERYEVI SEISKLIIPI
YEKRREFEKL TQVYRTLHGA YTKILEVMHT KKRLLGTFFR VAFYGQSFFE EEDGKEYIYK
EPKLTGLSEI SLRLVKLYGE KFGTENVKII QDSDKVNAKE LDPKYAHIQV TYVKPYFDDK
ELTERKTEFE RNHNISRFVF EAPYTLSGKK QGCIEEQCKR RTILTTSNSF PYVKKRIPIN
YEQQINLKPI DVATDEIKDR TAELQKLCSS ADVDMIQLQL KLQGCVSVQV NAGPLAYARA
FLNDSQASKY PPKKVNELKD MFRKFIQACS IALELNERLI KEDQIEYHEG LKSNFRDMVK
ELSDIIHEQI LQEDTMHSPW LSNTFHVFCA ISGTSSDRGY GSPRYAAEI
//
