ID F7B5D4_HORSE Unreviewed; 1858 AA.
AC F7B5D4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Dedicator of cytokinesis 1 {ECO:0000313|Ensembl:ENSECAP00000004637.4};
GN Name=DOCK1 {ECO:0000313|Ensembl:ENSECAP00000004637.4,
GN ECO:0000313|VGNC:VGNC:111222};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000004637.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000004637.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000004637.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000004637.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000004637.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSECAT00000006521.4; ENSECAP00000004637.4; ENSECAG00000023813.4.
DR VGNC; VGNC:111222; DOCK1.
DR GeneTree; ENSGT00940000154974; -.
DR HOGENOM; CLU_000595_1_0_1; -.
DR TreeFam; TF300423; -.
DR Proteomes; UP000002281; Chromosome 1.
DR Bgee; ENSECAG00000023813; Expressed in trophoblast and 23 other cell types or tissues.
DR ExpressionAtlas; F7B5D4; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08694; C2_Dock-A; 1.
DR CDD; cd11707; DHR2_DOCK1; 1.
DR CDD; cd12051; SH3_DOCK1_5_A; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR047025; DOCK1_5_SH3.
DR InterPro; IPR047026; DOCK1_C2.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF1; DEDICATOR OF CYTOKINESIS PROTEIN 1; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 2..63
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 418..602
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1200..1610
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1605..1709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1733..1767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1785..1858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 178..205
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1626..1655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1669..1708
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1733..1755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1816..1846
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1858 AA; 214514 MW; 3D6442A49FFE7C21 CRC64;
MEVCPGAAAF YNYDARGTDE LSLQIGDTVH ILETYEGWYR GYTLRKKSKK GIFPASYIHL
KEAIVEGKGQ HETVIPGDLP LIQEVTTTLR EWSTIWRQLY VQDNREMFRS VRHMIYDLIE
WRSQILSGTL PQDELKELKK KVTAKIDYGN RILDLDLVVR DEDGNILDPE LTSTISLFRA
HEIASKQVEE RLQEEKSQKQ NIEINRQAKF AATPSLALFV NLKNVVCKIG EDAEVLMSLY
DPVESKFISE NYLVRWSSSG LPKDIDRLHN LRAVFTDLGS KDLKREKISF VCQIVRVGRM
ELRDNNTRKL TSGLRRPFGV AVMDVTDIIN GKVDDEDKQH FIPFQPVAGE NDFLQTVINK
VIAAKEVNHK GQGLWVTLKL LPGDIHQIRK EFPHLVDRTT AVARKTGFPE IIMPGDVRND
IYVTLVQGDF DKGSKTTAKN VEVTVSVYDE DGKRLEHVIF PGAGDEAISE YKSVIYYQVK
QPRWFETVKV AIPIEDVNRT HLRFTFRHRS SQDSKDKSEK IFALAFVKLM RYDGTTLRDG
EHDLIVYKAE AKKLEDAATY LSLPSTKAEL EEKGHSATGK SMQSLGSCTI SKDSFQISTL
VCSTKLTQNV DLLGLLKWRS NTNLLQQNLR QLMKVDGGEV VKFLQDTLDA LFNIMMENSE
SETFDTLVFD ALVFIIGLIA DRKFQHFNPV LETYIKKHFS ATLAYTKLTK VLRNYVDNAE
KPGINDQLYK AMKALEYIFK FIVRSRILFN QLYENKGEAD FMESLLQLFR SISDMMSSVS
DQTVRVKGAA LKYLPTIVND VKLVFDPKEL SKMFTDFILN VPMGLLTIQK LYCLIEIIHS
DLFTQHDCRE ILLPMMTDQL KYHLERQEDL EACCQLLSNI LEVLYRKDVG PTQRHVQIIM
EKLLRTVNRT VISMGRDSEL IGNFVACMTA ILRQMEDYHY AHLIKTFGKM RTDVVDFLME
TFIMFKNLIG KNVYPFDWVI MNMMQNKVFL RAINQYADML NKKFLDQANF ELQLWNNYFH
LAVAFLTQES LQLENFSSAK RAKILNKYGD MRRQIGFEIR DMWYNLGQHK IKFIPEMVGP
ILEMTLIPET ELRKATIPIF FDMMQCEFHS TRSFQMFENE IITKLDHEVE GGRGDEQYKV
LFDKILLEHC RKHKYLAKTG ETFVNLVVRL MERLLDYRTI MHDENKENRM SCTVNVLNFY
KEIEREEMYI RYLYKLCDLH KECDNYTEAA YTLLLHAKLL KWSEDVCAAH LTQRDGYQAT
TQGQLKEQLY QEIIHYFDKG KMWEEAIALG KELAEQYENE MFDYEQLSEL LKKQAQFYEN
IVKVIRPKPD YFAVGYYGQG FPTFLRGKVF IYRGKEYERR EDFEARLLTQ FPNAEKMKTT
SPPGDDIKNS PGQYIQCFTV KPKLDLPPKF HRPVSEQIVS FYRVNEVQRF EYSRPIRKGE
KNPDNEFANM WIERTIYTTA YKLPGILRWF EVKSVFMVEI SPLENAIETM QLTNDKMNSM
VQQHLDDPSL PINPLSMLLN GIVDPAVMGG FANYEKAFFT ERYLQEHPEA HEKIEKLKDL
IAWQIPFLAE GIRIHGDKVT EALRPFHERM EACFKQLKEK VEKQYGVRTM PSSLDDRRGS
RPRSMVRSFT MPSSSRPLSV ASVSSLSSDS TPSRPGSDGF ALEPLLPKKM HSRSQDKLDK
DDADKEKKDK KKEKRNSKHQ EIFDKEFKPT DISLQQSEAV ILSETISPLR PQRPKSQVIN
VIGSERRFSV SPSSPSSQQT PPPVMPRAKL SFSVQSSLEL NGMTGMDVAE VPPPLPLKGS
TADYGNLMEN QDFIGSPTLP PPPPHQRHLP PPLPSKTPPP PPPKTTRKQT SVDSGIVQ
//
