ID F7B747_XENTR Unreviewed; 1355 AA.
AC F7B747;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Tenascin R {ECO:0000313|Ensembl:ENSXETP00000052900};
GN Name=tnr {ECO:0000313|Ensembl:ENSXETP00000052900};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000052900};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000052900}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000052900};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000052900}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the tenascin family.
CC {ECO:0000256|ARBA:ARBA00008673}.
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DR Ensembl; ENSXETT00000052900; ENSXETP00000052900; ENSXETG00000009195.
DR AGR; Xenbase:XB-GENE-948286; -.
DR Xenbase; XB-GENE-948286; tnr.
DR eggNOG; KOG1225; Eukaryota.
DR eggNOG; KOG2579; Eukaryota.
DR HOGENOM; CLU_001162_1_1_1; -.
DR InParanoid; F7B747; -.
DR TreeFam; TF329915; -.
DR Bgee; ENSXETG00000009195; Expressed in brain and 1 other cell type or tissue.
DR ExpressionAtlas; F7B747; baseline.
DR CDD; cd00063; FN3; 9.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR041161; EGF_Tenascin.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR46708; TENASCIN; 1.
DR PANTHER; PTHR46708:SF6; TENASCIN-R; 1.
DR Pfam; PF18720; EGF_Tenascin; 3.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR Pfam; PF00041; fn3; 9.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00186; FBG; 1.
DR SMART; SM00060; FN3; 9.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 6.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50853; FN3; 9.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..1355
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030169849"
FT DOMAIN 321..413
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 414..504
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 505..592
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 593..684
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 685..774
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 775..861
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 862..951
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 952..1037
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1038..1130
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1129..1344
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
SQ SEQUENCE 1355 AA; 150232 MW; BA5F4FC13303ED39 CRC64;
MGSEGVSSAL GPLQVGVHLI LLACLTRRSQ CQSELTGQTP RLDIQVDKGG NMTDHGIENK
QNPMVFNHVY NFNVPLSFPC TLEPETPEDG SWVTQQTENT ADAGSQITFT HSIRVPQRLC
QCYTTPHAVQ HLLSRIEALE REVMLLRERC NDRACQDAEA TGLTEFAPPC SGHGNFTVDS
CICNQGWGGE NCSEPLCPLE CSGRGTCIEG MCVCEPDYTG EWCTDLLCPE ECSPHGLCQD
GQCVCQDPYI GIGCTELRCP GDCLGKGRCA NGTCVCQDGY AGEDCGRMWC INACSGRGQC
QDGVCECEEG YSGQDCSEVA PPVDFSVTAV GDHWMDLAWE GTTAVTEYVI SYQPAVPGEW
GTQQRLQQRV PGDWSSVTIR ELEPGVTYNI SVCSVISDII SEPASITIST HISSPRGLNF
MEVTQTSVEV HWDPPVFPLD GWEISFTPKN NEGGLTVQLP SSVTSFNQTG LKPGEEYTVS
IISLKDQARS PATSGSISTD IDGPTNILVR DVTDTVAFVE WTPARAKLDF MQLDYGPING
EGEKTTFRLQ PPLSQYSMQV LRPGSQYEIS IRGVRGDTES EPVRATFTTE LDAPKNLRVI
SHASSTLELE WDNSEAEGEG YRVVYSTLAG DQYHELIVPR NYGQTTKATL TDLIPGTEYG
IGISAIRYNL KSAPATMNAR TELDSPTDLM VTGSTDKSIS LTWTKARGPI DHYRISFTPS
SGMASEVTVP SDISQYELSE LEPGTEYTIS IFAERGRQQS KETTIDAFTG FRPITQLHFS
AVTAYSVNVS WTDPSPPPDQ FILTYNPIDS KDPLQLFLDP SLRQTRLSAL QPSTEYMVTL
LPVHGTVRAE LVEGTVTTGV APPMDLSVIN VTENSLAVVW RPPPSSLHHY RLTYQSTKGR
MDSVVIGNDQ TRYTLANLMP NTEYKISLRS VRGREESERV GIVSWTAVDP PYGLRTSNIT
ATEAILHWEP PRSEVESYVI IVTHHAGSGE TILVDGESIE FQLQNLLPRT NYSVTLSANF
GHQTSRSVGV SFTTILDPPM NLTATEVART SALISWQPPI SPIENYILTY KSANESRKSL
LKLLLIVDAE DTWIRLEGLL ESTEYTVSIL SVQNGERSSV THTVFTTGGR VFSYPQDCAQ
HMLNGDNQSG VYYIYINGDM SQSVPVYCDM ATDAGGWIVF QRRQNGLTDF FRKWADYRVG
FGNLEDEFWL GLDTLHQVTS QGRYELRIDM RDGQEAVYAY YNKFNIGDAR SLYKLRIGDF
NGTSGDSLTY HQGRPFSTKD RDNDVAVTNC ASSYKGAWWY KNCHRTNLNG KYGESRHSQG
INWYHWKGHE FSIPFVEMKM RPYNHRTMKK RSLQL
//
