ID F7B8Q1_ORNAN Unreviewed; 1090 AA.
AC F7B8Q1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=StAR related lipid transfer domain containing 13 {ECO:0000313|Ensembl:ENSOANP00000024384.3};
GN Name=STARD13 {ECO:0000313|Ensembl:ENSOANP00000024384.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000024384.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000024384.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000024384.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000024384.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000024384.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_001511069.2; XM_001511019.4.
DR AlphaFoldDB; F7B8Q1; -.
DR STRING; 9258.ENSOANP00000024384; -.
DR Ensembl; ENSOANT00000024388.4; ENSOANP00000024384.3; ENSOANG00000015487.4.
DR GeneID; 100080170; -.
DR KEGG; oaa:100080170; -.
DR CTD; 90627; -.
DR eggNOG; KOG2200; Eukaryota.
DR GeneTree; ENSGT00950000183061; -.
DR HOGENOM; CLU_004367_0_0_1; -.
DR InParanoid; F7B8Q1; -.
DR OMA; CAIMKVE; -.
DR OrthoDB; 2883046at2759; -.
DR TreeFam; TF314044; -.
DR Proteomes; UP000002279; Chromosome 20.
DR Bgee; ENSOANG00000015487; Expressed in fibroblast and 7 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0043542; P:endothelial cell migration; IEA:Ensembl.
DR GO; GO:0097498; P:endothelial tube lumen extension; IEA:Ensembl.
DR GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04375; RhoGAP_DLC1; 1.
DR CDD; cd09592; SAM_DLC2; 1.
DR Gene3D; 1.10.287.2070; -; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 6.10.250.1870; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR12659; RHO-TYPE GTPASE ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR12659:SF6; STAR-RELATED LIPID TRANSFER PROTEIN 13; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50848; START; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 640..845
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 876..1059
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT REGION 149..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1090 AA; 120501 MW; C957819AC062877D CRC64;
MSSRRRAAKP LLRRSLSEQL RDSTAKAWDL LWKNVRERRL AEIEAKEACD WLRAAGFPQY
AQLYEDSQFP INIAAVKKDH DFLEKDLVEP LCRRLFTLNK CASMKLDVNF QRKKSDDSDE
EDLCISNKWT FQRSSKRWSR VNDLDSLFRG SDRHGSLGDA KMRNTTSSES VVTDLSEPEV
SSIHSESSGG SDGRGQAGGA GREASDRGGP DSAGGTPPAP GDATKNDRSA RTRTKTFLKR
METLRAWGTS DKPRGPGRAG GMVISGPVLQ QESEALKTLR CVQLVNGELG GAAPGGPSAS
LRPGCDHSRS VNGNDGGSGG STPGPKERRC HEPGKRGGMC FEGLEELMGT TLRQLSEQSR
GSEFHSQDDL VVLVPKDHKP GTFPKALSIE SLSPADPGGA VNWRTGSISL GRRQGPGRRE
PGLLAPCPRG SRVSVYDNVP GSHLCASTGD LLDLGRDELF PPVNEILQRI SGQPEAVDCW
PESLLSELRA EGKATGEGGP SPCPTPHHVA LDFEGNSGSD GRTTPSDMER DGASLNESEV
TGVRERRDSG VGASLTRPNR RSRWNSLHIA RLPAHAAASL RIGDQTAGQL NLLQKFSLLC
LTAIMEKNSL SNKHGWTWAV PKFMKRIKVP DYKDKNVFGV PLIVHVQRTG QPLPQSIQQA
LQYLRTNCLD QVGLFRKSGV KSRIQALRQM NESSPENVSY EDQSAYDVAD MVKQFFRDLP
EPLLTSKLGE TFLHIYQYVP ADQRLQAVQA AILLLSDENR EVLQMLLYFL NDVVSVVEEN
QMTPMNLAVC LAPSLFHLNL LKKEASPRVI QKKYATGKPD QKDLNENLAA TQGLAHMIRE
YKRLFEVPYE IVAQSQNSYV EAGICPLTME ELGKQLEEEG SHLQMYLESL SQGLQKEAKD
KFRGWVACPS VDNADLAFKK VGDGNPLRMW KASVEVEAPP AVVLNRVLRE RQLWDEDLLQ
EKLVETRDKQ TEVYQYVLRN MASLPTRDFV ILRTWRTDLP RGTCTLVALS VEHEEAPLLG
GVRAVVLDSQ YLIEPCGSGK SRLTHVCRID LRGHSPEWYN KGFGHLCAVE VARIRNSFQP
LMAGGPETKI
//
