ID F7BA30_MONDO Unreviewed; 1044 AA.
AC F7BA30;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=Ankyrin repeat and LEM domain containing 2 {ECO:0000313|Ensembl:ENSMODP00000018990.4};
GN Name=ANKLE2 {ECO:0000313|Ensembl:ENSMODP00000018990.4};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000018990.4, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000018990.4, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000018990.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ANKLE2 family.
CC {ECO:0000256|ARBA:ARBA00007597}.
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DR RefSeq; XP_007489642.1; XM_007489580.2.
DR AlphaFoldDB; F7BA30; -.
DR STRING; 13616.ENSMODP00000018990; -.
DR Ensembl; ENSMODT00000019332.4; ENSMODP00000018990.4; ENSMODG00000015199.4.
DR GeneID; 100027608; -.
DR KEGG; mdo:100027608; -.
DR CTD; 23141; -.
DR eggNOG; ENOG502QQ4Z; Eukaryota.
DR GeneTree; ENSGT00390000016767; -.
DR HOGENOM; CLU_017564_0_0_1; -.
DR InParanoid; F7BA30; -.
DR OMA; DLGCPHS; -.
DR OrthoDB; 5402020at2759; -.
DR TreeFam; TF317729; -.
DR Proteomes; UP000002280; Chromosome 3.
DR Bgee; ENSMODG00000015199; Expressed in blood and 20 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0051721; F:protein phosphatase 2A binding; IBA:GO_Central.
DR GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR GO; GO:0007084; P:mitotic nuclear membrane reassembly; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0042326; P:negative regulation of phosphorylation; IBA:GO_Central.
DR GO; GO:0035307; P:positive regulation of protein dephosphorylation; IBA:GO_Central.
DR CDD; cd12944; LEM_ANKL2; 1.
DR Gene3D; 1.10.720.40; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011015; LEM/LEM-like_dom_sf.
DR InterPro; IPR035006; LEM_ANKL2.
DR InterPro; IPR003887; LEM_dom.
DR PANTHER; PTHR12349; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR12349:SF4; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF03020; LEM; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00540; LEM; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF63451; LEM domain; 1.
DR PROSITE; PS50954; LEM; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT DOMAIN 103..147
FT /note="LEM"
FT /evidence="ECO:0000259|PROSITE:PS50954"
FT REGION 41..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 996..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..81
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 996..1019
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1044 AA; 116839 MW; A732EA6A8F14D776 CRC64;
MWWGEGFGEW KTLVWELLGA SVLVLLVRCL VRLREQWPRV PHRGSHSFSL GPVQGLQPFP
DSSPCPKPGP DQDPSPDPGL DPDPAALSEN DLHSGKLSMD VILARLKDLN SDDLREEIVK
AGLKCGPITS TTRFIFEKKL AQALLEQQGG IEGVFLSPPY QASENVAVNQ IGTKQTLQST
VVNPVKHTSL SEDRDFGYNM GLNPPEEDAL IHKSCSVPLS GMVHTDSQKD VSVPCKDPPL
YYGVCPVYED ILTRNERIHV YEDKKEALQA VKMIKGSRFK AFSNREDAEK FAKGICDYFP
SPSKTNFPLS PVKTVPFFNR DGLCSPESES MNKERANSFK SPRTQDLTAK LRKAVEKGDE
AAFSDLIWNN PRYLIGSGDN PTVVQEGCRY NVMHVATKEN QARICQLILD TLENPEFMRL
MYPDDDDVML QDRIRYIVDL YLNTPDKTGN DTPLHFACKF GNADVVNVLS SHPDVIKNPR
NKYLKTPEDV ICERSKNKSV ELKERIREYL KGHYYVPLLR AEDNSSPVIG DLWSPDQGDG
RPHVSTSRFG SSPKDPVLSV RAFAGPLSPS KAEDFRRRWK TPPRERADFF HNVRKSDPER
GVERVGRELA HELGYPWVEY WEFLDCFVDL SSQEGLRKLE EYLGQLEMSK IGLQETGENE
TLNRSKICNT SGRSKKCSNS ISVGAFLEEE DVISLEKIKN RQNAARNTCQ PLISQEPACG
TSGDSPGDIL SMEHTVKVID TSGLPGRHDE KGISSNRNGF CSPITKDRII CREKQKSQCG
KESFLSPVSN LMTEFDKLNL QDEGDRFFKK TNQVMGKNED ERILTSRMIQ VKISKDQVDK
TCANQIKENS LSEDATLVGK CENGKIRTGK GMSPEFDRLI FDSSAPDGGS QLCSQAQLQY
DSSVLSSESP SPRLFSKIPN ERTKRFFLQG EEPSKLDRDV LAAIERVEID PQKYPAISKW
KNTVQSFSTL ERQSWPSPAL KGKFRSQCST LCSPRSSLCS SPRRGSPGKY SNSCSPGLGS
PGRYSPAYAN LLLKIGHPTE PPTL
//