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Database: UniProt
Entry: F7BA30_MONDO
LinkDB: F7BA30_MONDO
Original site: F7BA30_MONDO 
ID   F7BA30_MONDO            Unreviewed;      1044 AA.
AC   F7BA30;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 3.
DT   24-JAN-2024, entry version 63.
DE   SubName: Full=Ankyrin repeat and LEM domain containing 2 {ECO:0000313|Ensembl:ENSMODP00000018990.4};
GN   Name=ANKLE2 {ECO:0000313|Ensembl:ENSMODP00000018990.4};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000018990.4, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000018990.4, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA   Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA   Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA   Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA   Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA   Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA   Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA   Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA   VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA   Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA   Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA   Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA   D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA   Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA   Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA   Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA   Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA   Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA   Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA   Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA   Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA   Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA   Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA   Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA   Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA   Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA   Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA   Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA   Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT   coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000018990.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the ANKLE2 family.
CC       {ECO:0000256|ARBA:ARBA00007597}.
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DR   RefSeq; XP_007489642.1; XM_007489580.2.
DR   AlphaFoldDB; F7BA30; -.
DR   STRING; 13616.ENSMODP00000018990; -.
DR   Ensembl; ENSMODT00000019332.4; ENSMODP00000018990.4; ENSMODG00000015199.4.
DR   GeneID; 100027608; -.
DR   KEGG; mdo:100027608; -.
DR   CTD; 23141; -.
DR   eggNOG; ENOG502QQ4Z; Eukaryota.
DR   GeneTree; ENSGT00390000016767; -.
DR   HOGENOM; CLU_017564_0_0_1; -.
DR   InParanoid; F7BA30; -.
DR   OMA; DLGCPHS; -.
DR   OrthoDB; 5402020at2759; -.
DR   TreeFam; TF317729; -.
DR   Proteomes; UP000002280; Chromosome 3.
DR   Bgee; ENSMODG00000015199; Expressed in blood and 20 other cell types or tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0051721; F:protein phosphatase 2A binding; IBA:GO_Central.
DR   GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR   GO; GO:0007084; P:mitotic nuclear membrane reassembly; IEA:Ensembl.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0042326; P:negative regulation of phosphorylation; IBA:GO_Central.
DR   GO; GO:0035307; P:positive regulation of protein dephosphorylation; IBA:GO_Central.
DR   CDD; cd12944; LEM_ANKL2; 1.
DR   Gene3D; 1.10.720.40; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR011015; LEM/LEM-like_dom_sf.
DR   InterPro; IPR035006; LEM_ANKL2.
DR   InterPro; IPR003887; LEM_dom.
DR   PANTHER; PTHR12349; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR   PANTHER; PTHR12349:SF4; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF03020; LEM; 1.
DR   SMART; SM00248; ANK; 2.
DR   SMART; SM00540; LEM; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF63451; LEM domain; 1.
DR   PROSITE; PS50954; LEM; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT   DOMAIN          103..147
FT                   /note="LEM"
FT                   /evidence="ECO:0000259|PROSITE:PS50954"
FT   REGION          41..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          534..553
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          996..1020
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..81
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        996..1019
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1044 AA;  116839 MW;  A732EA6A8F14D776 CRC64;
     MWWGEGFGEW KTLVWELLGA SVLVLLVRCL VRLREQWPRV PHRGSHSFSL GPVQGLQPFP
     DSSPCPKPGP DQDPSPDPGL DPDPAALSEN DLHSGKLSMD VILARLKDLN SDDLREEIVK
     AGLKCGPITS TTRFIFEKKL AQALLEQQGG IEGVFLSPPY QASENVAVNQ IGTKQTLQST
     VVNPVKHTSL SEDRDFGYNM GLNPPEEDAL IHKSCSVPLS GMVHTDSQKD VSVPCKDPPL
     YYGVCPVYED ILTRNERIHV YEDKKEALQA VKMIKGSRFK AFSNREDAEK FAKGICDYFP
     SPSKTNFPLS PVKTVPFFNR DGLCSPESES MNKERANSFK SPRTQDLTAK LRKAVEKGDE
     AAFSDLIWNN PRYLIGSGDN PTVVQEGCRY NVMHVATKEN QARICQLILD TLENPEFMRL
     MYPDDDDVML QDRIRYIVDL YLNTPDKTGN DTPLHFACKF GNADVVNVLS SHPDVIKNPR
     NKYLKTPEDV ICERSKNKSV ELKERIREYL KGHYYVPLLR AEDNSSPVIG DLWSPDQGDG
     RPHVSTSRFG SSPKDPVLSV RAFAGPLSPS KAEDFRRRWK TPPRERADFF HNVRKSDPER
     GVERVGRELA HELGYPWVEY WEFLDCFVDL SSQEGLRKLE EYLGQLEMSK IGLQETGENE
     TLNRSKICNT SGRSKKCSNS ISVGAFLEEE DVISLEKIKN RQNAARNTCQ PLISQEPACG
     TSGDSPGDIL SMEHTVKVID TSGLPGRHDE KGISSNRNGF CSPITKDRII CREKQKSQCG
     KESFLSPVSN LMTEFDKLNL QDEGDRFFKK TNQVMGKNED ERILTSRMIQ VKISKDQVDK
     TCANQIKENS LSEDATLVGK CENGKIRTGK GMSPEFDRLI FDSSAPDGGS QLCSQAQLQY
     DSSVLSSESP SPRLFSKIPN ERTKRFFLQG EEPSKLDRDV LAAIERVEID PQKYPAISKW
     KNTVQSFSTL ERQSWPSPAL KGKFRSQCST LCSPRSSLCS SPRRGSPGKY SNSCSPGLGS
     PGRYSPAYAN LLLKIGHPTE PPTL
//
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