ID F7BA47_HORSE Unreviewed; 746 AA.
AC F7BA47;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Ankyrin repeat domain 13B {ECO:0000313|Ensembl:ENSECAP00000009478.3};
GN Name=ANKRD13B {ECO:0000313|Ensembl:ENSECAP00000009478.3,
GN ECO:0000313|VGNC:VGNC:15322};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000009478.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000009478.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009478.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000009478.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009478.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Ubiquitin-binding protein that specifically recognizes and
CC binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked
CC ubiquitin. Positively regulates the internalization of ligand-activated
CC EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell
CC membrane. {ECO:0000256|ARBA:ARBA00024956}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Endosome {ECO:0000256|ARBA:ARBA00004177}. Late endosome
CC {ECO:0000256|ARBA:ARBA00004603}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR AlphaFoldDB; F7BA47; -.
DR SMR; F7BA47; -.
DR Ensembl; ENSECAT00000012046.3; ENSECAP00000009478.3; ENSECAG00000011408.4.
DR VGNC; VGNC:15322; ANKRD13B.
DR GeneTree; ENSGT00950000182928; -.
DR HOGENOM; CLU_026137_2_0_1; -.
DR OrthoDB; 20116at2759; -.
DR TreeFam; TF314176; -.
DR Proteomes; UP000002281; Chromosome 11.
DR Bgee; ENSECAG00000011408; Expressed in prefrontal cortex and 17 other cell types or tissues.
DR ExpressionAtlas; F7BA47; baseline.
DR GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR021832; ANKRD13.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR003903; UIM_dom.
DR PANTHER; PTHR12447; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13; 1.
DR PANTHER; PTHR12447:SF3; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13B; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF11904; GPCR_chapero_1; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50330; UIM; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT REPEAT 53..85
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 448..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 746 AA; 80681 MW; C9CE368DE8F9E9D4 CRC64;
MGLWGPWMLR QRLPHPQYLL CPGAPVISFL PKVGSPGYGL SPQLVDIEQL DPRGRTPLHL
ATTLGHLECA RVLLAHGADV GRENRSGWTV LQEAVSTRDL ELVQLVLRYR DYQRVVKRLA
GIPVLLEKLR KAQDFYVEMK WEFTSWVPLV SKICPSDTYK VWKSGQNLRV DTTLLGFDHM
TWQRGNRSFV FRGQDTSAVV MEIDHDRRVV YTETLALAGQ DRELLLAAAQ PTEEQVLSRL
TAPVVTTQLD TKNISFERNK TGILGWRSEK TEMVNGYEAK VYGASNVELI TRTRTEHLSE
QHKGKVKGCK TPLQSFLGIA EQHGGPQNGT LITQTLSQAN PTAITAEEYF NPNFELGNRD
MGRPMELTTK TQKFKAKLWL CEEHPLSLCE QVAPIIDLMA VSNALFAKLR DFITLRLPPG
FPVKIEIPIF HILNARITFG NLNGCDEPVP SVRGSPSSET PSPGSDSSSV SSSSSTTSCR
GCEISPALFE APRGYSVLGG QREAATRDDD DDLLQFAIQQ SLLEAGSEYD QVTIWEALTN
SKPGTHPMSC ESRRQDRCAP EPATYLTRPQ EHPAHAAAPA RAPSRPGDGP QPAAQPRLRP
RRPRVPELRR AAAAGHGAVG AGAGGAAAAR APGGGGAGAH PAAVADGAVA PTAGPLSHAT
RARPGSQIRP GPRARRAAAG DWSGRLGDLA ASQAPEGEGF GTAAGYLSGP GPWRQLARPG
PPALLYPDPH SSSLGSDLSK GGARRS
//
