ID F7BD57_CIOIN Unreviewed; 510 AA.
AC F7BD57; A0A1W2WFW6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Putative aminopeptidase W07G4.4 {ECO:0000313|Ensembl:ENSCINP00000009058.3};
GN Name=LOC100186137 {ECO:0000313|Ensembl:ENSCINP00000009058.3};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000009058.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000009058.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M17 family.
CC {ECO:0000256|ARBA:ARBA00009528}.
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DR EMBL; EAAA01001549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002127883.1; XM_002127847.3.
DR AlphaFoldDB; F7BD57; -.
DR MEROPS; M17.011; -.
DR Ensembl; ENSCINT00000009058.3; ENSCINP00000009058.3; ENSCING00000004383.3.
DR GeneID; 100186137; -.
DR KEGG; cin:100186137; -.
DR GeneTree; ENSGT00530000063255; -.
DR HOGENOM; CLU_013734_0_1_1; -.
DR OrthoDB; 1329669at2759; -.
DR Proteomes; UP000008144; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00433; Peptidase_M17; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR011356; Leucine_aapep/pepB.
DR InterPro; IPR000819; Peptidase_M17_C.
DR PANTHER; PTHR11963; LEUCINE AMINOPEPTIDASE-RELATED; 1.
DR PANTHER; PTHR11963:SF23; ZGC:152830; 1.
DR Pfam; PF00883; Peptidase_M17; 1.
DR PRINTS; PR00481; LAMNOPPTDASE.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00631; CYTOSOL_AP; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000256|ARBA:ARBA00022438};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 340..347
FT /note="Cytosol aminopeptidase"
FT /evidence="ECO:0000259|PROSITE:PS00631"
SQ SEQUENCE 510 AA; 55279 MW; 9CED7A73E8C2D570 CRC64;
MGLPCEIELV SKFENLNFDG VILVCEKLDD LKDSLSFLKK PLEDLKQIDD SVGKSVTVAA
LDGGLKRVIF APTGPLNRDY DDVRRFADAA ENGIKRAIKA GCQSPVLVTV KNDKFKYASF
VAALGAMQAL YVPLEIREAK PEKKNKLLKL GLWSGESSPY LIPTVDAFES GRSLVRDIQG
SDPERMAPPR VADYVTANFA NTNIKVEVVS DCDYIEKNYP CLGAVNRAAK VVPRHNARVI
KLFYEGSGPI TDTLFLVGKG VTYDTGGADV KAGGIMAGMH RDKGGASAVA GFFQILEKLK
PAHLKVYGTM SMVRNSIGAN GYVADEIITA RSGKRVRVGN TDAEGRMAMA DCLCEAKEMA
KNEVNPHLYT IATLTGHAII AMGPGYSIAM DNGPAREIQN SLKLRDAGDA VGDMFEISTI
RREDYVFHTG KSEYEDILQC NNAPSSRTPR GHQSPSAFMI MTSGLDSHGL DSDHPLKYTH
LDIAGSEGKF PGIPTGAPIT GLYSRYFGKH
//
