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Database: UniProt
Entry: F7BE26_ORNAN
LinkDB: F7BE26_ORNAN
Original site: F7BE26_ORNAN 
ID   F7BE26_ORNAN            Unreviewed;       622 AA.
AC   F7BE26;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 3.
DT   24-JAN-2024, entry version 68.
DE   RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
GN   Name=SLC6A18 {ECO:0000313|Ensembl:ENSOANP00000022771.4};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000022771.4, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000022771.4, ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000022771.4,
RC   ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA   Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA   Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA   Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA   Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA   Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA   Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA   Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA   Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA   Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA   Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA   Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA   Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA   Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA   Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA   de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000022771.4}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000022771.4};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC       2.A.22) family. {ECO:0000256|RuleBase:RU003732}.
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DR   AlphaFoldDB; F7BE26; -.
DR   STRING; 9258.ENSOANP00000022771; -.
DR   Ensembl; ENSOANT00000022775.4; ENSOANP00000022771.4; ENSOANG00000014449.4.
DR   eggNOG; KOG3659; Eukaryota.
DR   GeneTree; ENSGT00940000158906; -.
DR   HOGENOM; CLU_006855_7_2_1; -.
DR   InParanoid; F7BE26; -.
DR   OMA; MPGSQAW; -.
DR   OrthoDB; 3084493at2759; -.
DR   TreeFam; TF343812; -.
DR   Proteomes; UP000002279; Chromosome X3.
DR   Bgee; ENSOANG00000014449; Expressed in adult mammalian kidney and 1 other cell type or tissue.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR   GO; GO:0140931; F:neutral L-amino acid:sodium:chloride symporter activity; IEA:Ensembl.
DR   GO; GO:1990297; P:renal amino acid absorption; IEA:Ensembl.
DR   GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR000175; Na/ntran_symport.
DR   InterPro; IPR002438; Neutral_aa_SLC6.
DR   InterPro; IPR037272; SNS_sf.
DR   NCBIfam; NF037979; Na_transp; 1.
DR   PANTHER; PTHR11616:SF109; INACTIVE SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT3; 1.
DR   PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR   Pfam; PF00209; SNF; 1.
DR   PRINTS; PR00176; NANEUSMPORT.
DR   PRINTS; PR01206; ORPHTRNSPORT.
DR   SUPFAM; SSF161070; SNF-like; 1.
DR   PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR   PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR   PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Symport {ECO:0000256|RuleBase:RU003732};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003732};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT   TRANSMEM        28..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        58..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        100..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        180..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        210..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        254..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        291..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        401..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        444..463
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        475..498
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        519..539
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        568..593
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          599..622
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   622 AA;  70044 MW;  5AA5305BB50B2196 CRC64;
     MAVPLPEKGL LEEPKAGVRP QWDNKFQYLL SCVGFAVGLG NVWRFPYLCQ TYGGGAFLIP
     YFIALIFEGI PLFHLELAIG QRLRRGSLGV WKTISPYLGG VGIGSVIVSF LVSSYYNTIL
     MWVMWYFLNS FQAPLPWGSC PLDDNRTGPV EECQDSTAVN YFWYRRTLNI SPDINESGTL
     QWHLVMCSAV CWIIVYICTI RGIESTGKAI YFTALFPYLV LTIFLIRGLT LPGATEGLIY
     LFTPNMQILQ NPRVWLDAAT QIFFSLSLAS GGFIAFSSYN QPKNDCEKDA VIITLINSVT
     SLYASIAVFS VLGFKATSGY WDCMDRNIIS IINEFDFPEH SIQRHNYLDL LGHLNSTQPG
     RLAGLRLRSC RLQDFLDQSA SGPGLAFIVF TEAINRMPGS LVWALLFFGM LFSLGLSSMF
     GNIEGVLTPL LDTHFLSRSV PKEVLSGVIC LTCFLTALCF TLQSGSYWLE VFDKYGASIS
     LLILAFFEFI GIAYVYGMKR FGDDLEWMTG RRPNLYWQVA WKFVSPLLML IIFLAFLTLQ
     TQKQPTYGAW DPDYENFPTK QEKMYPGWGQ AICTLLPLCV CISIPSVALY HLINRWKGKR
     QTSGSNPYEN RSYDTVGDRG SE
//
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