ID   F7BFK5_HORSE            Unreviewed;       680 AA.
AC   F7BFK5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=Asteroid homolog 1 {ECO:0000313|Ensembl:ENSECAP00000011775.2};
GN   Name=ASTE1 {ECO:0000313|VGNC:VGNC:56714};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000011775.2, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000011775.2, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000011775.2,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000011775.2}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000011775.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the asteroid family.
CC       {ECO:0000256|ARBA:ARBA00007398}.
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DR   AlphaFoldDB; F7BFK5; -.
DR   STRING; 9796.ENSECAP00000011775; -.
DR   PaxDb; 9796-ENSECAP00000011775; -.
DR   Ensembl; ENSECAT00000014715.3; ENSECAP00000011775.2; ENSECAG00000014026.4.
DR   VGNC; VGNC:56714; ASTE1.
DR   GeneTree; ENSGT00390000010145; -.
DR   HOGENOM; CLU_017330_1_0_1; -.
DR   InParanoid; F7BFK5; -.
DR   OMA; AHQWNCP; -.
DR   TreeFam; TF324582; -.
DR   Proteomes; UP000002281; Chromosome 16.
DR   Bgee; ENSECAG00000014026; Expressed in blood and 23 other cell types or tissues.
DR   ExpressionAtlas; F7BFK5; baseline.
DR   GO; GO:0004518; F:nuclease activity; IEA:InterPro.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   InterPro; IPR026832; Asteroid.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR006085; XPG_DNA_repair_N.
DR   PANTHER; PTHR15665; ASTEROID PROTEIN; 1.
DR   PANTHER; PTHR15665:SF1; PROTEIN ASTEROID HOMOLOG 1; 1.
DR   Pfam; PF00752; XPG_N; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN          1..97
FT                   /note="XPG N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00752"
FT   REGION          621..645
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   680 AA;  77205 MW;  79FF8DFDCE648171 CRC64;
     MGIRGLMSFV EDHSNEFFID LKLRDTKIII DGYALFHRLC FNSNLELRYG GDYDSFADVV
     QKFFESLFAC NICPYVVLDG GCDISDKKLT TLKDRAREKI QMAHSLSVGG GGYVCPLLIR
     EVFIQVLIKL HVCFVQCFSE ADRDIMTLAN HWNCPVLSSD SDFCIFDLKS GFCPLNSFQW
     RNMNTLKGTR EHYIPAKCFS LDALCHHFSR MNKALLPLFA VLCGNDHINL PIMETFLSKV
     RLPLGGASSK GRRHHRVLGL LNWLSQFANP TEALDNVLQY LPKKNRENVK ELLCCSMEEY
     QPSQVKLQDF FQYGAYACPD ALNLALPEWV LVALAKGQLS PFISDALVLR RTILQTQVEN
     MQQPSAHRIS LPIRQTIYGL LLNASAHLEN TSWNALPLQR LAFSEVERIH KNIKTSIVDA
     VEVPKDHSDL STLTELSLAR RQILLLETLK VKQAVLDPIP PSLKLPIAVS CYWLQHTEAK
     AKLHHLQALL LGMLMGPLHA IIHSPDKEDL REDGAKMLYE EFQRVKEQTR PGTRLDLDTA
     HIFSQWQCCL QMGVYLNQLL STPLPEPDLT RLYSGSLVHG LSRQLLTTTS AESLLSMCSE
     AKQLYDHLFN ATRSHAPAEL FLPKGKSNPK KKRQKKRGTS WSKNRLGATS DTRCWYEGSN
     RFGLLMVENL EEHIETSEFE
//