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Database: UniProt
Entry: F7BG57_ORNAN
LinkDB: F7BG57_ORNAN
Original site: F7BG57_ORNAN 
ID   F7BG57_ORNAN            Unreviewed;       957 AA.
AC   F7BG57;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   05-JUN-2019, entry version 56.
DE   SubName: Full=Inositol polyphosphate-5-phosphatase B {ECO:0000313|Ensembl:ENSOANP00000003241};
GN   Name=INPP5B {ECO:0000313|Ensembl:ENSOANP00000003241};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000003241, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000003241}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000003241};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   STRING; 9258.ENSOANP00000003241; -.
DR   Ensembl; ENSOANT00000003242; ENSOANP00000003241; ENSOANG00000002045.
DR   eggNOG; KOG0565; Eukaryota.
DR   eggNOG; COG5411; LUCA.
DR   GeneTree; ENSGT00940000156762; -.
DR   InParanoid; F7BG57; -.
DR   OMA; MCERILT; -.
DR   TreeFam; TF317034; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000002045; Expressed in 6 organ(s), highest expression level in female gonad.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IBA:GO_Central.
DR   GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IBA:GO_Central.
DR   GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl.
DR   GO; GO:0046855; P:inositol phosphate dephosphorylation; IBA:GO_Central.
DR   GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IBA:GO_Central.
DR   GO; GO:0070613; P:regulation of protein processing; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR   CDD; cd09093; INPP5c_INPP5B; 1.
DR   Gene3D; 1.10.555.10; -; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.60.10.10; -; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR031896; INPP5B_PH_dom.
DR   InterPro; IPR000300; IPPc.
DR   InterPro; IPR037793; OCRL1/INPP5B_INPP5c.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   Pfam; PF16776; INPP5B_PH; 1.
DR   SMART; SM00128; IPPc; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF56219; SSF56219; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00280108};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT   DOMAIN      342    643       IPPc. {ECO:0000259|SMART:SM00128}.
FT   REGION      126    210       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F7BG57}.
FT   REGION      240    280       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F7BG57}.
SQ   SEQUENCE   957 AA;  107304 MW;  0D5B5AA9A8255113 CRC64;
     MDQSVAIQET LAEGEDCIVA VQGELCGADS VQSRLLGLVR WQQEHAARDH SLFLFTHCRM
     AITGEDLSLE QVVPITKEFT LEEVTTDSDL HVLGSDVTVR MESEEGSLVV RLPFGSHTRL
     FLQEVTRSRP GSPPTPLAGE TWSSPRFLCE DPDSNRPLPQ RLDPGPGGVV RGSSPIPGHL
     RAEENSNRPL PQRLDPGPGG VVRGSSPIPG HLRAEEFKEC LPARGQRAVN GRRVERKENF
     ITARDLGAGE KKRGPKGSSN MSSAPANGGG DGASGARCPA RVKGWATGQN KSKMESISNM
     VRSSTVTVSD KAHMLSMQKF GLRETIVKSQ LVQKEETYTY IQNFRFFVGT YNVNGQSPRE
     CLRPWLSRDV HPPDVYCVGF QELDLSKEAF FFNDTPKEEE WFKAVTDGLH PSAKYAKVKL
     VRLVGIMLLL YVKQEHALHL SEVEAETVGT GIMGRMGNKG GVAIRFRFHN TSICVVNSHL
     AAHTEEYERR NQDYKDICSR MQFCQRDPGL PPLTINKHDV ILWLGDLNYR IEELEADKVK
     KLIEEKEFQT LYKYDQLRNQ VADKAVFEGF MEGAISFQPT YKYDTGSDDW DTSEKCRAPA
     WCDRVLWKGK NVTQLSYQSH MALKTSDHKP VSSVFDIGVK VVNEELYRKT LEEIVRSLDK
     MENASIPSVT LSRRELSFQD VKNMEMQSQS FTIHNEQVPC QFEFINKPDE SSYCKPWLTV
     NPSKGFLLPG SHVEIELELF VNKTTATRLN SGEDRIEDIL VLHLTQGKDY FLSVSGNYRP
     SCFGSSIQML CHLREPIRDT PAETIRDLTL LPLRAGPVGS QEEKPLDIPK ELWMMVDFLY
     RNAARQEDLF QQPGLRSEFK QIRDCLDTGS PETLCILAAA LSPGLSAFEH SSEQIGKPPX
     LGAVNHTALD PGPLVLLSGM AISTLPTCYK NVFNYLMAFL RELLNNSARN HLDENIL
//
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