ID F7BHD3_MONDO Unreviewed; 1792 AA.
AC F7BHD3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=ADP ribosylation factor guanine nucleotide exchange factor 2 {ECO:0000313|Ensembl:ENSMODP00000020335.3};
GN Name=ARFGEF2 {ECO:0000313|Ensembl:ENSMODP00000020335.3};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000020335.3, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000020335.3, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000020335.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}.
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DR RefSeq; XP_007475834.1; XM_007475772.2.
DR STRING; 13616.ENSMODP00000020335; -.
DR Ensembl; ENSMODT00000020692.4; ENSMODP00000020335.3; ENSMODG00000016267.4.
DR GeneID; 100029328; -.
DR KEGG; mdo:100029328; -.
DR CTD; 10564; -.
DR eggNOG; KOG0929; Eukaryota.
DR GeneTree; ENSGT00940000158950; -.
DR HOGENOM; CLU_000691_1_0_1; -.
DR InParanoid; F7BHD3; -.
DR OMA; LNFKGMD; -.
DR OrthoDB; 204547at2759; -.
DR TreeFam; TF300714; -.
DR Proteomes; UP000002280; Chromosome 1.
DR Bgee; ENSMODG00000016267; Expressed in endometrium and 17 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0005815; C:microtubule organizing center; IEA:Ensembl.
DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR GO; GO:0007032; P:endosome organization; IEA:Ensembl.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0001881; P:receptor recycling; IEA:Ensembl.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032629; DCB_dom.
DR InterPro; IPR015403; Mon2/Sec7/BIG1-like_HDS.
DR InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR InterPro; IPR046455; Sec7/BIG1-like_C.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF124; BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 2; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF20252; BIG2_C; 1.
DR Pfam; PF16213; DCB; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF09324; Sec7-like_HDS; 1.
DR Pfam; PF12783; Sec7-like_HUS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 643..832
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 232..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1521..1542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1792 AA; 202618 MW; D457409A9E8791D1 CRC64;
MQESQTKSMF VSRALEKILA DKEAKRPQHS QLRRACQVAL DEIKAELEKQ RPGAAAPPKA
NFIEADKYFL PFELACQSKS PRVVSTSLDC LQKLIAYGHI TGNAPDSGAP GKRLIDRIVE
TVCNCFQGPQ TDEGVQLQII KALLTAVTSP HIEIHEGTIL QTVRTCYNIY LASKNLINQT
TAKATLTQML NVIFTRMENQ ALQEARELEK AMHPKPQSPV LQAVAGSPKF NRLKHNQLPS
KSSTPEKTDL NGEHQRRGSH EDRMENGEAQ LEGGPSLSGS EEIPSEGAHE VVKGILEDVV
TSAVKEATGK HGILDPERVL GELETKDLSS SGIDENSQTN GIADDRQSLS SADNLESDVH
GPQVAAKFSH ILQKDAFLVF RSLCKLSMKP LGEGPPDPKS HELRSKVVSL QLLLSVLQNA
GPVFRTHEMF INAIKQYLCV ALSKNGVSSV PDVFELSLAI FLTLLSNFKT HLKMQIEVFF
KEIFLNILET STSSFEHKWM VIQTLTRICA DAQCVVDIYV NYDCDLNAAN IFERLVNDLS
KIAQGRSGHE LGMTPLQELS LRKKGLECLV SILKCMVEWS KDLYVNPNHQ TSLGQERTTD
QDLVEPKGLD IGRRSSVSSM DSTVSSGIGS VATQTSVPDD PEQFEVIKQQ KEIIEHGIEL
FNKKPKRGIQ YLQEQGMLGT PVEDIAQFLH QEERLDSTQV GDFLGESTRL NKEVMYAYVD
QLDFCGKDFV SALRIFLEGF RLPGEAQKID RLMEKFAARY LECNQGQTMF ASADTAYVLA
YSIIMLTTDL HSPQVKNKMT KEQYIKMNRG INDSKDLPEE YLSTIYEEIE GKKIAMKETK
EHTIATKSNK QNVASEKQRR LLYNLEMEQM AKTAKALMEA VSHAKAPFTS ATHLDHVRPM
FKLVWTPLLA AYSIGLQNCD ETEVASLCLE GIRCAIRIAC IFGMQLERDA YVQALARFSL
LTASSSITEM KQKNIDTIKT LITVAHTDGN YLGNSWHEIL KCISQLELAQ LIGTGVKTRY
LSGSGREKES NLKGYTSAGE EFMGLGLGNL VGGGVDKRQM ASIQESVGET SSQSVVVAVD
RIFTGSTRLD GNAIVDFVRW LCAVSMDELA SPHHPRMFSL QKIVEISYYN MNRIRLQWSR
IWQVIGDHFN KVGCNPNEDV AIFAVDSLRQ LSMKFLEKGE LANFRFQKDF LRPFEHIMKK
NRSPTIRDMV IRCITQMVNS QAANIRSGWK NIFAVFHQAA SDHDGNIVEL AFQTTGHIVT
TIFQHHFPAA IDSFQDAVKC LSEFACNASF PDTSMEAIRL IRYCGKYVSE RPRVLQEYTS
DDMNVAPGDR VWVRGWFPIL FELSCIINRC KLDVRTRGLT VMFEIMKSYG HTFEKHWWQD
LFRIVFRIFD NMKLPEQQSE KSEWMTTTCN HALYAICDVF TQFYEALNEV LLSDVFAQLH
WCVKQDNEQL ARSGTNCLEN LVISNGEKFS PDVWDETCNC MLDIFKTTIP HILLTWKPAG
MEDDTSEKHL DLDLDRQSLS SIDKNPSERG QSQISNPTDD SWKGRPYTNQ KLFASLLIKC
VVQLELIQTI DNIVFYPATS KKEDAEHMVA AQRDTLDADI HIDTEDQGMY KYMSSQHLFK
LLDCLQESHS FSKAFNSNYE QRTVLWRAGF KGKSKPNLLK QETSSLACCL RILFRMYIDE
NRKDSWEEIQ HRLLSVCSEA LGYFITVNSE SHREAWTSLL LLLLTKTLKI SDEKFKAHAS
MYYPYLCEIM QFDLIPELRA VLRKFFLRIG AVYKIWIPKE PLQLTGTQVP AW
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