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Database: UniProt
Entry: F7BHW1_MOUSE
LinkDB: F7BHW1_MOUSE
Original site: F7BHW1_MOUSE 
ID   F7BHW1_MOUSE            Unreviewed;       900 AA.
AC   F7BHW1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   24-JAN-2024, entry version 70.
DE   SubName: Full=Cadherin, EGF LAG seven-pass G-type receptor 2 {ECO:0000313|Ensembl:ENSMUSP00000122329.2};
DE   Flags: Fragment;
GN   Name=Celsr2 {ECO:0000313|Ensembl:ENSMUSP00000122329.2,
GN   ECO:0000313|MGI:MGI:1858235};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000122329.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000122329.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000122329.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000122329.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000122329.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   MaxQB; F7BHW1; -.
DR   ProteomicsDB; 316563; -.
DR   Antibodypedia; 2940; 247 antibodies from 30 providers.
DR   Ensembl; ENSMUST00000147251.2; ENSMUSP00000122329.2; ENSMUSG00000068740.15.
DR   UCSC; uc008qyz.2; mouse.
DR   AGR; MGI:1858235; -.
DR   MGI; MGI:1858235; Celsr2.
DR   VEuPathDB; HostDB:ENSMUSG00000068740; -.
DR   GeneTree; ENSGT00940000157493; -.
DR   HOGENOM; CLU_015145_0_0_1; -.
DR   ChiTaRS; Celsr2; mouse.
DR   Proteomes; UP000000589; Chromosome 3.
DR   Bgee; ENSMUSG00000068740; Expressed in skin of snout and 258 other cell types or tissues.
DR   ExpressionAtlas; F7BHW1; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 1.25.40.610; -; 1.
DR   Gene3D; 2.60.220.50; -; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR032471; GAIN_dom_N.
DR   InterPro; IPR046338; GAIN_dom_sf.
DR   InterPro; IPR017981; GPCR_2-like_7TM.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR000203; GPS.
DR   PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR12011:SF347; LATROPHILIN CIRL; 1.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF16489; GAIN; 1.
DR   Pfam; PF01825; GPS; 1.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   SMART; SM00303; GPS; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR   PROSITE; PS50221; GPS; 1.
PE   1: Evidence at protein level;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|MaxQB:F7BHW1,
KW   ECO:0007829|ProteomicsDB:F7BHW1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        368..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        402..418
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        424..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        469..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        509..529
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        550..572
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        578..601
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          365..602
FT                   /note="G-protein coupled receptors family 2 profile 2"
FT                   /evidence="ECO:0000259|PROSITE:PS50261"
FT   REGION          207..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          670..900
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        838..857
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|Ensembl:ENSMUSP00000122329.2"
SQ   SEQUENCE   900 AA;  98445 MW;  02B14425CDD657CD CRC64;
     XEHRGWLPPN LFNCTSVTFS ELKGFAERLQ RNESGLDSGR SQRLALLLRN ATQHTSGYFG
     SDVKVAYQLA TRLLAHESAQ RGFGLSATQD VHFTENLLRV GSALLDAANK RHWELIQQTE
     GGTAWLLQHY EAYASALAQN MRHTYLSPFT IVTPNIVISV VRLDKGNFAG TKLPRYEALR
     GERPPDLETT VILPESVFRE MPSMVRSAGP GEAQETEELA RRQRRHPELS QGEAVASVII
     YHTLAGLLPH NYDPDKRSLR VPKRPVINTP VVSISVHDDE ELLPRALDKP VTVQFRLLET
     EERTKPICVF WNHSILVSGT GGWSARGCEV VFRNESHVSC QCNHMTSFAV LMDMSRRENG
     EILPLKTLTY VALGVTLAAL MLTFLFLTLL RALRSNQHGI RRNLTAALGL AQLVFLLGIN
     QADLPFACTV IAILLHFLYL CTFSWALLEA LHLYRALTEV RDVNASPMRF YYMLGWGVPA
     FITGLAVGLD PEGYGNPDFC WLSVYDTLIW SFAGPVAFAV SMSVFLYILS ARASCAAQRQ
     GFEKKGPVSG LRSSFTVLLL LSATWLLALL SVNSDTLLFH YLFAACNCVQ GPFIFLSYVV
     LSKEVRKALK FACSRKPSPD PALTTKSTLT SSYNCPSPYA DGRLYQPYGD SAGSLHSASR
     SGKSQPSYIP FLLREESTLN PGQVPPGLGD PSGLFLEGQA QQHDPDTDSD SDLSLEDDQS
     GSYASTHSSD SEEEEEEAAF PGEQGWDSLL GPGAERLPLH STPKDGGPGS GKVPWLGDFG
     TTTKENSGSG PLEERPRENG DALTREGSLG PLPGPSTQPH KGILKKKCLP TISEKSSLLR
     LPLEQGTGSS RGSSISEGSR HGPPPRPPPR QSLQEQLNGV MPVAMSIKAG TVDEDSSGSE
//
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