ID F7BHW1_MOUSE Unreviewed; 900 AA.
AC F7BHW1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE SubName: Full=Cadherin, EGF LAG seven-pass G-type receptor 2 {ECO:0000313|Ensembl:ENSMUSP00000122329.2};
DE Flags: Fragment;
GN Name=Celsr2 {ECO:0000313|Ensembl:ENSMUSP00000122329.2,
GN ECO:0000313|MGI:MGI:1858235};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000122329.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000122329.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000122329.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000122329.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000122329.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR MaxQB; F7BHW1; -.
DR ProteomicsDB; 316563; -.
DR Antibodypedia; 2940; 247 antibodies from 30 providers.
DR Ensembl; ENSMUST00000147251.2; ENSMUSP00000122329.2; ENSMUSG00000068740.15.
DR UCSC; uc008qyz.2; mouse.
DR AGR; MGI:1858235; -.
DR MGI; MGI:1858235; Celsr2.
DR VEuPathDB; HostDB:ENSMUSG00000068740; -.
DR GeneTree; ENSGT00940000157493; -.
DR HOGENOM; CLU_015145_0_0_1; -.
DR ChiTaRS; Celsr2; mouse.
DR Proteomes; UP000000589; Chromosome 3.
DR Bgee; ENSMUSG00000068740; Expressed in skin of snout and 258 other cell types or tissues.
DR ExpressionAtlas; F7BHW1; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF347; LATROPHILIN CIRL; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|MaxQB:F7BHW1,
KW ECO:0007829|ProteomicsDB:F7BHW1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 368..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 469..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 578..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 365..602
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 207..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..857
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000122329.2"
SQ SEQUENCE 900 AA; 98445 MW; 02B14425CDD657CD CRC64;
XEHRGWLPPN LFNCTSVTFS ELKGFAERLQ RNESGLDSGR SQRLALLLRN ATQHTSGYFG
SDVKVAYQLA TRLLAHESAQ RGFGLSATQD VHFTENLLRV GSALLDAANK RHWELIQQTE
GGTAWLLQHY EAYASALAQN MRHTYLSPFT IVTPNIVISV VRLDKGNFAG TKLPRYEALR
GERPPDLETT VILPESVFRE MPSMVRSAGP GEAQETEELA RRQRRHPELS QGEAVASVII
YHTLAGLLPH NYDPDKRSLR VPKRPVINTP VVSISVHDDE ELLPRALDKP VTVQFRLLET
EERTKPICVF WNHSILVSGT GGWSARGCEV VFRNESHVSC QCNHMTSFAV LMDMSRRENG
EILPLKTLTY VALGVTLAAL MLTFLFLTLL RALRSNQHGI RRNLTAALGL AQLVFLLGIN
QADLPFACTV IAILLHFLYL CTFSWALLEA LHLYRALTEV RDVNASPMRF YYMLGWGVPA
FITGLAVGLD PEGYGNPDFC WLSVYDTLIW SFAGPVAFAV SMSVFLYILS ARASCAAQRQ
GFEKKGPVSG LRSSFTVLLL LSATWLLALL SVNSDTLLFH YLFAACNCVQ GPFIFLSYVV
LSKEVRKALK FACSRKPSPD PALTTKSTLT SSYNCPSPYA DGRLYQPYGD SAGSLHSASR
SGKSQPSYIP FLLREESTLN PGQVPPGLGD PSGLFLEGQA QQHDPDTDSD SDLSLEDDQS
GSYASTHSSD SEEEEEEAAF PGEQGWDSLL GPGAERLPLH STPKDGGPGS GKVPWLGDFG
TTTKENSGSG PLEERPRENG DALTREGSLG PLPGPSTQPH KGILKKKCLP TISEKSSLLR
LPLEQGTGSS RGSSISEGSR HGPPPRPPPR QSLQEQLNGV MPVAMSIKAG TVDEDSSGSE
//