ID F7BKC0_HORSE Unreviewed; 358 AA.
AC F7BKC0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Gap junction protein {ECO:0000256|RuleBase:RU000630};
GN Name=GJA5 {ECO:0000313|Ensembl:ENSECAP00000019879.1,
GN ECO:0000313|VGNC:VGNC:18352};
GN Synonyms=CXNI {ECO:0000313|EMBL:VZP20287.1};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000019879.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000019879.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019879.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|EMBL:VZP20287.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1038/s41598-019-53458-x;
RA Premzl M.;
RT "Comparative genomic analysis of eutherian connexin genes.";
RL Sci. Rep. 9:16938-16938(2019).
RN [3] {ECO:0000313|Ensembl:ENSECAP00000019879.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019879.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell.
CC {ECO:0000256|ARBA:ARBA00003922, ECO:0000256|RuleBase:RU000630}.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC {ECO:0000256|ARBA:ARBA00011455, ECO:0000256|RuleBase:RU000630}.
CC -!- SUBCELLULAR LOCATION: Cell junction, gap junction
CC {ECO:0000256|ARBA:ARBA00004610}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU000630}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the connexin family. Alpha-type (group II)
CC subfamily. {ECO:0000256|ARBA:ARBA00006589}.
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DR EMBL; LT990487; VZP20287.1; -; Genomic_DNA.
DR RefSeq; XP_005610270.1; XM_005610213.2.
DR RefSeq; XP_005610271.1; XM_005610214.2.
DR RefSeq; XP_005610272.1; XM_005610215.2.
DR STRING; 9796.ENSECAP00000019879; -.
DR PaxDb; 9796-ENSECAP00000019879; -.
DR Ensembl; ENSECAT00000023956.3; ENSECAP00000019879.1; ENSECAG00000022462.3.
DR Ensembl; ENSECAT00000083154.1; ENSECAP00000089992.1; ENSECAG00000022462.3.
DR Ensembl; ENSECAT00000084399.1; ENSECAP00000065680.1; ENSECAG00000022462.3.
DR Ensembl; ENSECAT00000086374.1; ENSECAP00000064234.1; ENSECAG00000022462.3.
DR Ensembl; ENSECAT00000089256.1; ENSECAP00000077124.1; ENSECAG00000022462.3.
DR Ensembl; ENSECAT00000101435.1; ENSECAP00000067732.1; ENSECAG00000022462.3.
DR Ensembl; ENSECAT00000116758.1; ENSECAP00000073397.1; ENSECAG00000022462.3.
DR Ensembl; ENSECAT00000116952.1; ENSECAP00000077450.1; ENSECAG00000022462.3.
DR Ensembl; ENSECAT00000134689.1; ENSECAP00000058110.1; ENSECAG00000022462.3.
DR Ensembl; ENSECAT00000147407.1; ENSECAP00000071507.1; ENSECAG00000022462.3.
DR GeneID; 100065052; -.
DR KEGG; ecb:100065052; -.
DR CTD; 2702; -.
DR VGNC; VGNC:18352; GJA5.
DR GeneTree; ENSGT01050000244864; -.
DR HOGENOM; CLU_037388_0_0_1; -.
DR OMA; FIHIHYG; -.
DR OrthoDB; 5301774at2759; -.
DR TreeFam; TF329606; -.
DR Proteomes; UP000002281; Chromosome 5.
DR Bgee; ENSECAG00000022462; Expressed in synovial membrane of synovial joint and 17 other cell types or tissues.
DR GO; GO:0005922; C:connexin complex; IBA:GO_Central.
DR GO; GO:0086076; F:gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling; IBA:GO_Central.
DR GO; GO:0086044; P:atrial cardiac muscle cell to AV node cell communication by electrical coupling; IBA:GO_Central.
DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR GO; GO:0007507; P:heart development; IBA:GO_Central.
DR Gene3D; 1.20.1440.80; Gap junction channel protein cysteine-rich domain; 1.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR002264; Connexin40.
DR InterPro; IPR034634; Connexin_C.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR InterPro; IPR031862; Cx40_C.
DR PANTHER; PTHR11984; CONNEXIN; 1.
DR PANTHER; PTHR11984:SF13; GAP JUNCTION ALPHA-5 PROTEIN; 1.
DR Pfam; PF00029; Connexin; 1.
DR Pfam; PF16791; Connexin40_C; 1.
DR PRINTS; PR00206; CONNEXIN.
DR PRINTS; PR01135; CONNEXINA5.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
DR SUPFAM; SSF118220; Connexin43; 1.
DR PROSITE; PS00407; CONNEXINS_1; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Gap junction {ECO:0000256|ARBA:ARBA00022868,
KW ECO:0000256|RuleBase:RU000630};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000630};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..76
FT /note="Connexin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00037"
FT DOMAIN 163..229
FT /note="Gap junction protein cysteine-rich"
FT /evidence="ECO:0000259|SMART:SM01089"
FT REGION 323..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 358 AA; 40748 MW; 3F698E133CA0846A CRC64;
MGDWSYLAEF LEEVHKHSTE IGKVWLTVLF IFRILVLVTA AESSWGDEQA DFLCDTLQPG
CENVCYDQAF PISHIRYWVL QVIFVSTPSL VYLFHTMHRV RMQEKQRQRE AERAKHVQGA
GSYEYPVAEK TALSCWEEGN EKIVLQGTLL NTYVCSILIR TTMEVAFIVG QYLLYGIFLD
TLHVCRRSPC PHPVNCYVSR PTEKNVFIVF MLAVAGLSLF LSLVELYHLG WKRIRQRFAR
SRQGMAECQL PGPSAGIVQK CTPPLDFNQC LENGPGGKFF NPFSNKMASQ QNIDNLATEQ
VRDQEQIPGE GFIHIRYAQK PEVPNGVSPG HRLPHCYQND KPRLSKASSK ARSDDLSV
//