ID F7BL12_ORNAN Unreviewed; 954 AA.
AC F7BL12;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Dystrophin related protein 2 {ECO:0008006|Google:ProtNLM};
GN Name=DRP2 {ECO:0000313|Ensembl:ENSOANP00000006701.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000006701.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000006701.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000006701.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000006701.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000006701.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7BL12; -.
DR STRING; 9258.ENSOANP00000006701; -.
DR Ensembl; ENSOANT00000006703.2; ENSOANP00000006701.2; ENSOANG00000004217.3.
DR eggNOG; KOG4286; Eukaryota.
DR GeneTree; ENSGT00940000153467; -.
DR HOGENOM; CLU_001187_0_0_1; -.
DR OrthoDB; 2880153at2759; -.
DR TreeFam; TF337303; -.
DR Proteomes; UP000002279; Chromosome 6.
DR Bgee; ENSOANG00000004217; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd16248; EFh_DRP-2; 1.
DR CDD; cd00176; SPEC; 1.
DR CDD; cd00201; WW; 1.
DR CDD; cd02334; ZZ_dystrophin; 1.
DR Gene3D; 1.20.58.60; -; 2.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR015153; EF-hand_dom_typ1.
DR InterPro; IPR015154; EF-hand_dom_typ2.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR12268:SF16; DYSTROPHIN-RELATED PROTEIN 2; 1.
DR PANTHER; PTHR12268; E3 UBIQUITIN-PROTEIN LIGASE KCMF1; 1.
DR Pfam; PF09068; EF-hand_2; 1.
DR Pfam; PF09069; EF-hand_3; 1.
DR Pfam; PF00435; Spectrin; 1.
DR Pfam; PF00397; WW; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00150; SPEC; 2.
DR SMART; SM00456; WW; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 2.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 348..381
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 601..657
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT REGION 20..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 779..873
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 23..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 897..916
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 954 AA; 107390 MW; D6F7A941DADC56D7 CRC64;
MQPMVMPGCP YTLPRCHEWR APDQSQRSSS LSNPRPQPQG PVVAAGTQDG AGPPSPCLNQ
QLPSGPGRPP APLDMNLCWS EIKKKSHSLR ARLEAFSDQS GKLQAPLQEI VDWLGHKDEE
LSAQLPLRGD VALVQQEKET HAAFMEEVKA RGPYIYSVLE SAQTFLAQHP FEELEEPQTE
GRDVSPRLRG QNGSRLVWKQ ATVASELWEK LTARCVDQHR HIERTLEQLL DVRRAMEELD
ASLGQAEGVR ATWEPIGDLF IDSLPDHIQT TKLFKEELSP MKDGVKLVND RAHQLAISDV
HLSMENSRAL EQINTRWKQL QTSVSERLKQ LQDAHRDFGP GSQHFLATSV QVPWERAISP
NKVPYYINHQ AQTTCWDHPK MTELYQTLAE LNNIKFSAYR TAMKLRRVQK ALRLDLVPLS
TALEIFNEHE LQPGEHVMDV VEVIHCLTAL YERLEEERGI LVNVPLCVDM TLNWLLNVYD
SGRSGKMRAL SFKTGIACLC GTDVKEKFQY LFSQVAHPGG LCDQRHLGIL LHEAIQVPRQ
LGEVAAFGGS NVEPSIRSCF RFSTGKPVVE VAQFLEWANL EPQSMVWLAV LHRVALAEPV
KHQTKCSVCR HCPIKGFRYR SLKQFNVDIC QMCFLTGRAS KGNKLHYPIM EYYTPTTSSE
NMRDFATTLK NKFRSKHYFS RHPQRGYLPV QSVLEADFSE TPASSPVLPH ADTHSRIEHF
ASRLAEMESQ NCSFFNDSQS PDDSIDEDQY LLRHSSPITD REPAGGQQAQ GSPPGEEDKG
TLEKILAHLE DENRILQGEL RRLKWQHEEA GEAPPLAAGT PEAAQDPHNE ELLAEARILR
QHKSRLETRM QILEDHNKQL ESQLQRLREL LLQPPADLDG TGSAGSSLAS SPQPSEGSHA
REREHNTPDT EVADEIVAKS QDVSLCLEDI MEKLRNAFPN APSPEPTPNA LLAS
//
