ID F7BLA4_MONDO Unreviewed; 454 AA.
AC F7BLA4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Solute carrier family 41 member {ECO:0000256|RuleBase:RU369007};
GN Name=SLC41A3 {ECO:0000313|Ensembl:ENSMODP00000009463.2};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000009463.2, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000009463.2, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000009463.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a magnesium transporter.
CC {ECO:0000256|RuleBase:RU369007}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU369007}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369007}.
CC -!- SIMILARITY: Belongs to the SLC41A transporter family.
CC {ECO:0000256|ARBA:ARBA00009749, ECO:0000256|RuleBase:RU369007}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU369007}.
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DR RefSeq; XP_007500355.1; XM_007500293.2.
DR RefSeq; XP_007500356.1; XM_007500294.2.
DR RefSeq; XP_007500357.1; XM_007500295.1.
DR AlphaFoldDB; F7BLA4; -.
DR STRING; 13616.ENSMODP00000009463; -.
DR Ensembl; ENSMODT00000009649.3; ENSMODP00000009463.2; ENSMODG00000007626.3.
DR GeneID; 100026674; -.
DR CTD; 54946; -.
DR eggNOG; KOG3788; Eukaryota.
DR GeneTree; ENSGT00950000183042; -.
DR HOGENOM; CLU_018207_2_0_1; -.
DR InParanoid; F7BLA4; -.
DR OrthoDB; 5124745at2759; -.
DR TreeFam; TF313647; -.
DR Proteomes; UP000002280; Chromosome 6.
DR Bgee; ENSMODG00000007626; Expressed in skeletal muscle tissue and 18 other cell types or tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0061768; F:magnesium:sodium antiporter activity; IEA:Ensembl.
DR GO; GO:0045016; P:mitochondrial magnesium ion transmembrane transport; IEA:Ensembl.
DR Gene3D; 1.10.357.20; SLC41 divalent cation transporters, integral membrane domain; 2.
DR InterPro; IPR006667; SLC41_membr_dom.
DR InterPro; IPR036739; SLC41_membr_dom_sf.
DR InterPro; IPR045349; SLC41A1-3.
DR PANTHER; PTHR16228; DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41; 1.
DR PANTHER; PTHR16228:SF22; SOLUTE CARRIER FAMILY 41 MEMBER 3; 1.
DR Pfam; PF01769; MgtE; 2.
DR SUPFAM; SSF161093; MgtE membrane domain-like; 2.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU369007};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU369007};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369007};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU369007};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU369007};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU369007}.
FT TRANSMEM 60..82
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 143..166
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 178..203
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 247..268
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 280..298
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 372..390
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 402..421
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT DOMAIN 101..235
FT /note="SLC41A/MgtE integral membrane"
FT /evidence="ECO:0000259|Pfam:PF01769"
FT DOMAIN 314..452
FT /note="SLC41A/MgtE integral membrane"
FT /evidence="ECO:0000259|Pfam:PF01769"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 454 AA; 50087 MW; 884B842BFF9A2D8F CRC64;
MMRGEEARQR RKEGQLGSEK QLQSRGESPG HPSTQDVPWT SQKRYPFETE TSLEETALTI
FLQALLPFVL AGVGMTVAGM FLDFVKHWKV FVDIKELLTL VPSLVGLKGN LEMTLASRFS
TAANTGVIDN PQEQQKMIFG NLALVQVQAT VVGLLAALVA LVLEFISGQK VELSHIGVLC
ASSVVTAFVA AFFLGVTMIG VILTARKLGI NPDNIATPIA AMLGDVIALS ILALISSIFY
KYIEKYYIFL GICLFFFALI PMWIIIVNQS PSIFQVLKTG WYPIIISMFI SSLGGLIFSK
AVSEKDFKGM AFFTPVVNGV GGNLVSIQVS RISTYLYSWS TLGVLPYNMK SYWPNPCTTF
CSSEINSVSA RVLLLLVVPG QLIFLFIIHL KEGDEIGLNP LFVVMYLIGS FTQVLILLYL
ADFMVRLIWR WSQDPDSYCI PYLTGLGDLL GSAY
//
