ID F7BLZ9_XENTR Unreviewed; 142 AA.
AC F7BLZ9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Cyclin-dependent kinase inhibitor 1 isoform X2 {ECO:0000313|RefSeq:XP_031752659.1};
DE SubName: Full=Cyclin-dependent kinase inhibitor 1A {ECO:0000313|Ensembl:ENSXETP00000053500};
GN Name=cdkn1a {ECO:0000313|Ensembl:ENSXETP00000053500,
GN ECO:0000313|RefSeq:XP_031752659.1,
GN ECO:0000313|Xenbase:XB-GENE-487802};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000053500};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000053500}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000053500};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000053500}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_031752659.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031752659.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031752659.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CDI family. {ECO:0000256|ARBA:ARBA00006726}.
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DR RefSeq; XP_031752659.1; XM_031896799.1.
DR Ensembl; ENSXETT00000053500; ENSXETP00000053500; ENSXETG00000024887.
DR AGR; Xenbase:XB-GENE-487802; -.
DR Xenbase; XB-GENE-487802; cdkn1a.
DR eggNOG; KOG4743; Eukaryota.
DR HOGENOM; CLU_077692_1_1_1; -.
DR TreeFam; TF101038; -.
DR Proteomes; UP000008143; Chromosome 2.
DR Bgee; ENSXETG00000024887; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IEA:InterPro.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IEA:InterPro.
DR GO; GO:0072331; P:signal transduction by p53 class mediator; IEA:InterPro.
DR Gene3D; 4.10.365.10; p27; 1.
DR InterPro; IPR003175; CDI_dom.
DR InterPro; IPR044898; CDI_dom_sf.
DR InterPro; IPR029841; CDKN1A.
DR PANTHER; PTHR46778:SF1; CYCLIN-DEPENDENT KINASE INHIBITOR 1; 1.
DR PANTHER; PTHR46778; CYCLIN-DEPENDENT KINASE INHIBITOR 1-RELATED; 1.
DR Pfam; PF02234; CDI; 1.
PE 3: Inferred from homology;
KW Protein kinase inhibitor {ECO:0000256|ARBA:ARBA00023013};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 26..73
FT /note="Cyclin-dependent kinase inhibitor"
FT /evidence="ECO:0000259|Pfam:PF02234"
FT REGION 105..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 142 AA; 16465 MW; E7B859CA577029A4 CRC64;
MKEKMQSAIA ILKQASGNKE KACRMLFEAV DHEQLKTEFH ELMQRSNEEA KAKWNFDFVT
ETPLEGQYDW EKVEDKTLNC NSQESEKENQ CQDVAAEMCN INQSHKASQN CESSDSGKRK
QKLITDFYPV KRRCSPKPSP RD
//
