ID F7BNJ6_HORSE Unreviewed; 398 AA.
AC F7BNJ6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=TRAF family member associated NFKB activator {ECO:0000313|Ensembl:ENSECAP00000016578.4};
GN Name=TANK {ECO:0000313|Ensembl:ENSECAP00000016578.4,
GN ECO:0000313|VGNC:VGNC:58941};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000016578.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000016578.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016578.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000016578.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016578.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7BNJ6; -.
DR Ensembl; ENSECAT00000020209.4; ENSECAP00000016578.4; ENSECAG00000019097.4.
DR VGNC; VGNC:58941; TANK.
DR GeneTree; ENSGT00390000008712; -.
DR HOGENOM; CLU_143212_0_0_1; -.
DR Proteomes; UP000002281; Chromosome 18.
DR Bgee; ENSECAG00000019097; Expressed in bone marrow and 23 other cell types or tissues.
DR ExpressionAtlas; F7BNJ6; baseline.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IEA:InterPro.
DR InterPro; IPR039669; TANK.
DR InterPro; IPR024581; TBD.
DR PANTHER; PTHR15249; TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR; 1.
DR PANTHER; PTHR15249:SF0; TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR; 1.
DR Pfam; PF12845; TBD; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 133..186
FT /note="Tbk1/Ikki binding"
FT /evidence="ECO:0000259|Pfam:PF12845"
FT REGION 90..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 27..61
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 90..119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 398 AA; 44802 MW; BBD50A0E4FDAC260 CRC64;
MDKNIGEQLN KAYEAFRQAC MDRDSAVKEL QQKTENYEQR IREQQEQLSL QQTIIDKLKL
QLLLVNSSRD NSYGYVPLLE DSEARKNNLT LDAPLDKVKS GIPREKESKV RRQEVSSPRK
ETSPRSLGIP LFHERGYIEK TFCDLKEEFH RICMLAKAQK DHLSKLNVPV TATETQCSVP
VQCTDKTDKQ EVLFKPQAKD DINRGAPCIT SVTPRGVGQD EEDTSFESLS KLNIKFPPMD
SDSTFLHSTA ERPNVLGPAT SEAVCQDKFN VEFRDNPGNF VKTEETLFEI QGIDPIASAI
QNLKTTDKTK PSNPVNTCIR TALDRAPCLP PGDHNALYVN TFPLQDPSDA SFPSLDSPGK
AIRGPQQSVH SCFSRWHPAL CICFLCYSKG NSWYVITT
//
