ID F7BQJ4_XENTR Unreviewed; 659 AA.
AC F7BQJ4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Protein tyrosine phosphatase, receptor type E {ECO:0000313|Ensembl:ENSXETP00000011309};
GN Name=ptpre {ECO:0000313|Ensembl:ENSXETP00000011309};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000011309};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000011309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000011309};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000011309}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
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DR AlphaFoldDB; F7BQJ4; -.
DR STRING; 8364.ENSXETP00000011309; -.
DR Ensembl; ENSXETT00000011309; ENSXETP00000011309; ENSXETG00000005190.
DR AGR; Xenbase:XB-GENE-982136; -.
DR Xenbase; XB-GENE-982136; ptpre.
DR eggNOG; KOG4228; Eukaryota.
DR HOGENOM; CLU_001645_8_0_1; -.
DR OrthoDB; 2875525at2759; -.
DR TreeFam; TF351829; -.
DR Bgee; ENSXETG00000005190; Expressed in brain and 7 other cell types or tissues.
DR ExpressionAtlas; F7BQJ4; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14620; R-PTPc-E-1; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF499; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE EPSILON; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 155..413
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 333..404
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 445..659
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 619..659
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 659 AA; 75205 MW; 4319D23391126FEA CRC64;
MRPSSASVIP AETAAHSGAH RTMMGLPYSL LFYFILKVCD VLAAADNETY TTQPSLTTPP
ENDTGSLLTS VLVPLLVCFV LILLAGYLLR SRKHRKADVN TSDKKMPNGI LEEQEQQTVM
LLSSSPTVYK KYFPIPVENL EEEFRIRSAD DGKLFREEYN SLQPGSIHGT HEAANKEENK
EKNRYPNILP YDQSRVILIP VDGGPCSDYI NASYIDGYKE RNKFIAAQGP KQETVNDFWR
MIWEQKSATI VMLTNLKERK EDKCYQYWPD QGCWIYGNIR VAVEDVVVLV DYTIRKFCIQ
PVHDGCKAPR LITQLHFTSW PDFGVPFTPI GMLKFLKKVK SVNPVHAGPI VVHCSAGVGR
TGTFIVIDAI IDMMNEEKKV NVFDFVSKIR NQRPQMVQTD MQYSFIYQAL LEYYLYGDTE
LDVASLEKHL QALYTPAPHF DKIGLEQEFK KLTSVRIMKE NMRTGNLPAN MKKARVIQII
PYDFNRVILS MKRGEEYTDY INASFIDGYR QKDYFIATQG PLPHTVEDFW RMVWEWKSHT
IVILTELQER EQEKCCQYWP SEGTVTHGEI NIEIKSDRLL DTISVRDFIV TSSQEKQTRL
VRQFHFHGWP EIGIPAEGKG MIDLIAAVQK QQQQTGNHPI VVHCSAGAGR TGTFIAVGG
//
