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Database: UniProt
Entry: F7BRW9_XENTR
LinkDB: F7BRW9_XENTR
Original site: F7BRW9_XENTR 
ID   F7BRW9_XENTR            Unreviewed;       348 AA.
AC   F7BRW9;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 4.
DT   24-JAN-2024, entry version 75.
DE   SubName: Full=Transcription factor 7 {ECO:0000313|Ensembl:ENSXETP00000035132};
GN   Name=tcf7 {ECO:0000313|Ensembl:ENSXETP00000035132};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000035132};
RN   [1] {ECO:0000313|Ensembl:ENSXETP00000035132}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000035132};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000035132}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the TCF/LEF family.
CC       {ECO:0000256|ARBA:ARBA00006569}.
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DR   AlphaFoldDB; F7BRW9; -.
DR   Ensembl; ENSXETT00000035132; ENSXETP00000035132; ENSXETG00000016100.
DR   Xenbase; XB-GENE-855462; tcf7.
DR   eggNOG; KOG3248; Eukaryota.
DR   HOGENOM; CLU_013229_5_0_1; -.
DR   TreeFam; TF318448; -.
DR   Bgee; ENSXETG00000016100; Expressed in cardiogenic splanchnic mesoderm and 44 other cell types or tissues.
DR   ExpressionAtlas; F7BRW9; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd21996; HMG-box_TCF7-like; 1.
DR   Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR   Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR   InterPro; IPR027397; Catenin-bd_sf.
DR   InterPro; IPR013558; CTNNB1-bd_N.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR024940; TCF/LEF.
DR   PANTHER; PTHR10373:SF33; TRANSCRIPTION FACTOR 7; 1.
DR   PANTHER; PTHR10373; TRANSCRIPTION FACTOR 7 FAMILY MEMBER; 1.
DR   Pfam; PF08347; CTNNB1_binding; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; HMG-box; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT   DOMAIN          250..318
FT                   /note="HMG box"
FT                   /evidence="ECO:0000259|PROSITE:PS50118"
FT   DNA_BIND        250..318
FT                   /note="HMG box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT   REGION          1..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          320..348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   348 AA;  39350 MW;  A74F761A4D6FBE58 CRC64;
     MPQMNSAGED DLGASDEMIS FKDEGDQEEK IRESAFTERD LADLKSSLVN ESEVSSHPRV
     PESHPEAMRR TQDAQLVYQD KLTDHMEDGV KHQDEGMYKG SGYPSYPFLM LSDPYLSNGS
     VSALSSKVPV VQPSHGVHPL IPYNNESFSH GSHSTHLPAD LNQKQGVHRP AQTADIPTFY
     PLPSGGVGQI SPSVGWFPHP LMLSPSMHTT GIPHPAIIPH SGNKDIDCYE RNMKPHSEPK
     REREPKKPTI KKPLNAFMLY MKEMRAKVIA ECTLKESAAI NQILGRRWHA LSREEQSKYY
     ELARKERQLH MQLYPGWSAR DNYGKRKRRT REKHQDSSSG VQVFKSLN
//
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