ID F7BSK4_XENTR Unreviewed; 811 AA.
AC F7BSK4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Extracellular calcium-sensing receptor {ECO:0000313|Ensembl:ENSXETP00000023122};
GN Name=LOC100491800 {ECO:0000313|Ensembl:ENSXETP00000023122};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000023122};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000023122}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000023122};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000023122}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; F7BSK4; -.
DR Ensembl; ENSXETT00000023122; ENSXETP00000023122; ENSXETG00000031915.
DR eggNOG; KOG1056; Eukaryota.
DR HOGENOM; CLU_005389_5_1_1; -.
DR InParanoid; F7BSK4; -.
DR TreeFam; TF331269; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF547; VOMERONASAL 2, RECEPTOR 118-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170}; Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..811
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030169883"
FT TRANSMEM 538..561
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 573..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 609..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 651..670
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 697..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 732..752
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 764..788
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 538..802
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 811 AA; 90001 MW; 20D5525D4D68FA01 CRC64;
GKWWHSSGVF FIRNFQQLQA MIFAVNEINT NPNILPNITL GFQVYDSCDV LQQDLEGTLQ
VLTGHTGAIS NYRCLKNTPL AAVIGASSST HSILMAHVLG LYRYPQVSYF STSPLLSNHK
MFPSFFRTVP SDAFQSQGLA KLVLHFGWTW VGLLAADNDY GQQGIQLVKQ EIIKAGACVA
FTESILTSQP DRNAQHIVKV MKESTATAIV IFSPTIYLVP ILEQMFIQNV TKKILVASEA
WSTSTLFSNG KFSEVLSGTI GLALHSGGIP GFGDFLNKIH PSVSLGQYWV RLLWEKSFNC
KFQNESHLTS ASADAMQKCT GEERLGNIAN SFNDVSSLRV TYNVYTAVHA VANALEALTN
CISERSKFSN QKCPSISNFT SWQVICNINY DQKVKIPLSS GRMLIFDENG DPPAVYDIVN
WKLRPDGSMK QVNVGSYDIT AAFGHVFSVN MSAISWATGH QQVPLSVCSQ SCPPGFRKAT
VREKPACCFQ CIPCPQGEIS NHTDSINCYK CSWDEWPNLQ KSKCLQKNIE YLSYEDPLGA
GLAATGIASF WVPVLVLNVF IKYKSTPIVK ANNYCLSCLL LLCLPLCFLC SLAFIGYPQP
EKCLLRQAAF GLVFTLCISC ILAKTFMVVF AFMATKPGSR IKKWTSPSVS YMIIFICFGL
QFILCISWLL EAPPFPQYDI QTKPGVIIIE CNNGSATAFW CMLGYLGFLA AISFAVAFLA
RRLPDNFNEA KFITFSMLAF LSVWVSFIPA SLSAQGKYTE AMEIFAILSS TWSLVVCLFL
PKCFIIVFRP NMNSKKELMK KTSAHLQISM Y
//
