ID F7BUK6_HORSE Unreviewed; 1179 AA.
AC F7BUK6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Diaphanous related formin 3 {ECO:0000313|Ensembl:ENSECAP00000017323.3};
GN Name=DIAPH3 {ECO:0000313|Ensembl:ENSECAP00000017323.3,
GN ECO:0000313|VGNC:VGNC:17185};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017323.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000017323.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017323.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000017323.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017323.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC subfamily. {ECO:0000256|ARBA:ARBA00008214}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7BUK6; -.
DR Ensembl; ENSECAT00000021056.4; ENSECAP00000017323.3; ENSECAG00000019161.4.
DR VGNC; VGNC:17185; DIAPH3.
DR GeneTree; ENSGT00940000157767; -.
DR HOGENOM; CLU_002356_0_0_1; -.
DR TreeFam; TF315383; -.
DR Proteomes; UP000002281; Chromosome 17.
DR Bgee; ENSECAG00000019161; Expressed in inner cell mass and 15 other cell types or tissues.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.58.630; -; 1.
DR Gene3D; 6.10.30.30; -; 1.
DR Gene3D; 1.10.20.40; Formin, diaphanous GTPase-binding domain; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR044933; DIA_GBD_sf.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF9; PROTEIN DIAPHANOUS HOMOLOG 3; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR PRINTS; PR00049; WILMSTUMOUR.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 100..462
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 622..1020
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 1043..1073
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 499..536
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 901..963
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 995..1041
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 15..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..619
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1179 AA; 135210 MW; 8BEB953528D6BD08 CRC64;
MDRHRPRLHH PAQSSSAGAP CSSSALPRSS RESKMPRRKG PQHPPPPGGL EEPGEKRPKF
LDKFASIRIP GSKKERPPLS NLKTAFASND CSSEMMENIP KPLSENELLE LFEKMMEDMN
LNEDKKAPLR EKDFSIKKEM VMQYINTASK TGSLKRSRQI SSQEFIYELK MGCADERLVT
CLESLRVSLT SNPVSWVESF GHEGLGLLLD ILEKLISGKI QEKIVKKNQH KVIQCLKALM
NTQYGLERIM SEERSLSLLA KAIDPEHPNM MTDVVKLLSA VCIVGEENIL EEVLEALTTA
GEERKIDRFF SIVEGLRHNS VQLQVACMQL INALVTSPDD LDFRLHIRNE FMRCGLKEML
PNLKRIKNDG LDIQLKVFDE HKEEDLIEFS HRLEDIRAEL DEAYDVYNMV WNTVKETRAE
GYFISILQHL LLIRNDYFIR QQYFKLIDEC VSQIVLHRDG MDPDFTYRKR LDLDLSQFVD
ICIDQAKLEE FEEKASDLFK KFEKEFTDHQ ETQAQLQKKE AEINELQAEL QAFKSQFGAL
PAGTNTSLPL SKENGTSHPA LPPAPPLPFC GGAPPPPPPP PPPPLPGMPM PFGGPVPPPP
PLGFLSGRNS PPPPALPFGL KPKKEFKPEA NMRRLNWLKI RPHEMTENCF WIKANENKYE
NIDLLCKLEN TFCCQQKEKR EEDDFEEKKA IKKKIKELKF LDSKIAQNLS IFLSSFRVPY
EEIKMMILEV DETQLAESMI QNLIKHLPDQ EQLNSLSQFK SDYNNLCEPE QFAVVMSNVK
RLRPRLSAIL FKLQFEEQVN NIKPDIMAVS TACEEIKKSR SFSKLLELVL LMGNYMNAGS
RNAQTFGFNL SSLCKLKDTK SADQKTTLLH FLVEVCEEKY PDILNFVDDM EHLDKASKVS
VETLEKNLKQ MGRQLQQLEK DLETFPPPED LHDKFVTKMS SFVISAKEQY EKLSKLHENM
EKLYQSIMQY YAIDVKKVSV EDFLTDLNNF RTTVMQAIKE NVKKREAEER EKRARIAKEL
AEKERLERQQ KKKRLLEMKT EGDETGVMDS LLEALQSGAA FRDRRKRTPK PKDIRQSLSP
MSQRPILKVC NHENQKGQLT EGSRSHYNIN CNSARTPVAK ELNYNLDTPT STGRIKAVEK
KEACNVESNR KKEMELLGSV SKNESIPEVE ALLARLRAL
//