ID   F7BVQ5_CALJA            Unreviewed;      1038 AA.
AC   F7BVQ5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 3.
DT   27-MAR-2024, entry version 66.
DE   RecName: Full=Presequence protease, mitochondrial {ECO:0000256|ARBA:ARBA00020167};
DE   AltName: Full=Pitrilysin metalloproteinase 1 {ECO:0000256|ARBA:ARBA00032857};
GN   Name=PITRM1 {ECO:0000313|Ensembl:ENSCJAP00000037981.4};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000037981.4, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000037981.4}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000037981.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBUNIT: Monomer and homodimer; homodimerization is induced by binding
CC       of the substrate. {ECO:0000256|ARBA:ARBA00011853}.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family. PreP subfamily.
CC       {ECO:0000256|ARBA:ARBA00007575}.
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DR   AlphaFoldDB; F7BVQ5; -.
DR   STRING; 9483.ENSCJAP00000037981; -.
DR   Ensembl; ENSCJAT00000040122.5; ENSCJAP00000037981.4; ENSCJAG00000020425.5.
DR   eggNOG; KOG2019; Eukaryota.
DR   GeneTree; ENSGT00390000018381; -.
DR   InParanoid; F7BVQ5; -.
DR   OMA; NYLYYIR; -.
DR   TreeFam; TF300333; -.
DR   Proteomes; UP000008225; Chromosome 7.
DR   Bgee; ENSCJAG00000020425; Expressed in heart and 6 other cell types or tissues.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:Ensembl.
DR   GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR   GO; GO:0006508; P:proteolysis; IEA:Ensembl.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR013578; Peptidase_M16C_assoc.
DR   PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR   PANTHER; PTHR43016:SF13; PRESEQUENCE PROTEASE, MITOCHONDRIAL; 1.
DR   Pfam; PF08367; M16C_assoc; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   SMART; SM01264; M16C_associated; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT   DOMAIN          504..753
FT                   /note="Peptidase M16C associated"
FT                   /evidence="ECO:0000259|SMART:SM01264"
FT   REGION          804..836
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        804..818
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1038 AA;  117410 MW;  891277B8E72798C2 CRC64;
     MWRCGGRPGL LTLRQLSGGH AYHKAWRWSS TRACERALQY QVGDKIHGFT VNQVTSVPEL
     FLTAVKLSHD DTGARYLHLA REDTNNLFSV QFRTTPMDST GVPHILEHTV LCGSQKYPCR
     DPFFKMLNRS LSTFMNAFTA SDYTLYPFST QNPKDFQNLL SVYLDATFFP CLRELDFWQE
     GWRLEHENPS DPQTPLVFKG VVFNEMKGVF TDNERIFSQH LQNRLLPDHT YSVVSGGDPL
     CIPELTWEQL KQFHATHYHP SNARFFTYGN FPLEQHLKQI QEEALSKFQK IEPSTAVPAQ
     TPWDKPREFQ ITCGPDSLAT DPSKQRTVSV SFLLPDITDT FEAFTLSLLS SLLISGPNSP
     FYKALIESGL GTDFSPDVGY NGYTREAYFS VGLQGIAEKD IETVRSLVDR TIDEVIEKGF
     EDERIEALLH KIEIQMKHQS TSFGLTLTSY IASCWNHDGD PVELLKLGNQ LAKFRQCLQE
     NPKFLEEKVK QYFKNNQHKL TLSMRPDDKY REKQAQVEAT KLKQKVEALS PRDRQQIYEK
     GLELRTRQSK PQDASCLPAL KVSDIEPTIP ATELDVVLTA GDIPVQYCSQ PTNGMVYFRA
     FCSLNTLPEE LRPYVPLFCS VLTKLGCGLL DYREQAQQIE LKTGGMSASP HVLPDDSHMD
     TYEQVGVLFS SHCLDRNLSD MMHLWSEIFN NPCFEEEEHF KVLVKMTAQE LANGIPDSGH
     LYASIRAGRT LTPAGDLREA FSGMDQVRLM KRIAEMTDIK PILRKLPRIK KHLLNGDNMR
     CSVNATPQQM AETEKVVENF LRNIGRSKKE RRPVRPHVVE KPAPSSPGGD AHTPNGSQII
     RKLVMEPTFK PWQMKTHFLM PFPVNYVGEC IRTVPYTDPD HASLKILACL MTAKFLHTEI
     REKGGAYAGG AKLSHNGIFT FYSYRDPNTM ETLQSFGKAV DWAKSGKFTQ QDIDEAKLSA
     FSTVDAPVAP SDKGMDHFLS GLSDDMKQAH REQLFAVSRD KLLAVSDRYL GTGKSTHGLA
     ILGPENAKIA KDPSWIVS
//