GenomeNet

Database: UniProt
Entry: F7BWC3_HORSE
LinkDB: F7BWC3_HORSE
Original site: F7BWC3_HORSE 
ID   F7BWC3_HORSE            Unreviewed;       456 AA.
AC   F7BWC3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   16-OCT-2019, entry version 59.
DE   SubName: Full=ETS proto-oncogene 1, transcription factor {ECO:0000313|Ensembl:ENSECAP00000008998};
GN   Name=ETS1 {ECO:0000313|Ensembl:ENSECAP00000008998,
GN   ECO:0000313|VGNC:VGNC:17700};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000008998, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000008998, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008998,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000008998}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008998};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594391}.
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DR   PaxDb; F7BWC3; -.
DR   Ensembl; ENSECAT00000011498; ENSECAP00000008998; ENSECAG00000010897.
DR   VGNC; VGNC:17700; ETS1.
DR   eggNOG; KOG3806; Eukaryota.
DR   eggNOG; ENOG410Z0ZF; LUCA.
DR   GeneTree; ENSGT00940000159519; -.
DR   InParanoid; F7BWC3; -.
DR   OrthoDB; 526256at2759; -.
DR   TreeFam; TF316214; -.
DR   Proteomes; UP000002281; Chromosome 7.
DR   Bgee; ENSECAG00000010897; Expressed in 3 organ(s), highest expression level in liver.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd08542; SAM_PNT-ETS-1; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR041886; SAM_PNT-ETS-1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   DNA-binding {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN       95    180       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      379    456       ETS. {ECO:0000259|PROSITE:PS50061}.
SQ   SEQUENCE   456 AA;  51847 MW;  E10404915377F4DB CRC64;
     MSYFVDSTVS GPAPYPAAHP AVARQGPINS YEAPRMACDF QSNYYPQRAC YPFWDEMATQ
     EVPTGLEHCG SDMECADVPL LTPSSKEMMS QALKATFSGF SKEQQRLGIP KDPRQWTETH
     VRDWVMWAVN EFSLKGVDFQ KFCMNGAALC ALGKDCFLEL APDFVGDILW EHLEILQKED
     VKPYPVNGVN PTYPESRYTS DYFISYGIEH AQCVPPSEFS EPSFITESYQ TLHPISSEEL
     LSLKYENDYP SVILRDPLQT DTLQTDYFAI KQEVVTPDNM CMGRTSRGKL GGQDSFESIE
     SYDSCDRLTQ SWSSQSSFNS LQRVPSYDSF DSEDYPAALP NHKPKGTFKD YVRDRADLNK
     DKPVIPAAAL AGYTGSGPIQ LWQFLLELLT DKSCQSFISW TGDGWEFKLS DPDEVARRWG
     KRKNKPKMNY EKLSRGLRYY YDKNIIHKTA ANNFPL
//
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