ID F7BXU0_HORSE Unreviewed; 3851 AA.
AC F7BXU0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Lysosomal trafficking regulator {ECO:0000313|Ensembl:ENSECAP00000005944.3};
GN Name=LYST {ECO:0000313|Ensembl:ENSECAP00000005944.3,
GN ECO:0000313|VGNC:VGNC:19866};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000005944.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000005944.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000005944.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000005944.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000005944.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9796.ENSECAP00000005944; -.
DR PaxDb; 9796-ENSECAP00000005944; -.
DR Ensembl; ENSECAT00000008004.4; ENSECAP00000005944.3; ENSECAG00000006981.4.
DR VGNC; VGNC:19866; LYST.
DR GeneTree; ENSGT00940000156359; -.
DR InParanoid; F7BXU0; -.
DR OMA; MGAPPEF; -.
DR OrthoDB; 47483at2759; -.
DR TreeFam; TF313658; -.
DR Proteomes; UP000002281; Chromosome 1.
DR Bgee; ENSECAG00000006981; Expressed in blood and 23 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0032510; P:endosome to lysosome transport via multivesicular body sorting pathway; IEA:Ensembl.
DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0043473; P:pigmentation; IEA:Ensembl.
DR GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF163; LYSOSOMAL-TRAFFICKING REGULATOR; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 3059..3165
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 3170..3472
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3662..3696
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 151..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 917..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1010..1030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1182..1204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3851 AA; 434452 MW; 8375A3806CAFADEE CRC64;
MSTDSNSLAR EFLTDVNRLC NAVVQRVEAR EEEEEETHMA TLGQYLVHGR GFLLLTKLNS
IIDQALTCRE ELLTLLLSLL PLVWKIPVQE EKATDFHLPF SADIILTKEK ISSSQRSAQE
KLYLEGSAPS GQVSAKVNIF RKSRRQRKIT HRYSIRDARK TQLSTSDSEA NSDDKGIAVN
KHKRSHLLQH FVTHSPKEDH LTAELDHLST KEEHTPPDTM ALGNSREIIP RKESNSDTLS
EPAALSIISH MNNSPFDLCH VLLSLLEKVC KFDITLNRNS ALAASVVPTL TEFLAGFGDC
CNLSDSLDSR MVSTGWTEEP VALIQRMLFR TVLHLMSVDI STAEMMPESL RKNLTELLRA
ALKIRTYLEK QPDAFAPRQK KTLQEVQEGF VFSKYRHRAL LLPELLKGVL QIMICCLQSA
ASNPFFFSQA MDLVQEFIQH HGFNLFETTV LQMEWLVLRD GVPTEASEHL KALISSVIKI
MSTVKKVKSE QLHHSVCTRK RHRRCEYSHF MHHHRDLSGL PVSTFKNQVS KNPFEETVDG
DVYYPERCCC IAVCAHQCLR LLLQASLKGT CVQILSGVHN IGICCCMDPK SVIIPLLHAF
KLPALKNFQQ HILNILNKLI LDQLGGAEIT QKIKKAACNI CTIDSDQLAK LEETLQGNSW
DAEPSSSLSS PSYRFQGVLP SSGCEALLWK WDALETYQNF VFEQDRLHSL QIANHICSLI
QKGNVFVQWK LYNYVFNPVL QRGVELAHHC QHLSNTSAQT HVCSHHNQCL PQEVLQIYLK
TLPALLKSRV IRDLFLSCNG VNQIIELNYL DDIRSHSLKA FETLIISLGE QPKDSSIPGI
DGIDVEQKEL SSLNAGTSFH NQHAYSDSPQ SLSKFYAGLK ETCLKKQKTL NQNVHINMIN
LFLCVAFLCV SKEAESDREP ANESEDTSGY DSTASEPLHH MLPSLSPESL VLPSPEQMHQ
AADIWLMCRW IYMLSPVFQK QFYRLGGFQV CHRLIFMIIK KLFRSREEEQ GKKEGDININ
ENQDLNRTSE SEVTMKEDLL SLTVKSDPTP SEQDSLKRSA ESLHKLESQH ISSMNVEQIS
TTKAASEEAK IFTSKESEPS LQSIRLLEAL LAICLHSTRA SQQKMELELP DQNLSVENIL
FEMRDHLSQS KVIETELAKP LFDALLRVAL GNHSADFEHN DAMTEKSHQS EEELSSQPGD
FSEEAEDSQC CSFKLLVEEE GYEADSESNP EDSEIRDDEV DLNPEAEGLS ASSSPNDLLE
NPSQGEMIYP EICMLQLNLL STSKAKLDVL AHVFESFLKI IRQKEKNIFL LMQQGTVKNL
LGGFLSILTQ ADSDFQVCQR VLVDLLVSLM SSRTCSEELT LLLRIFLEKS PCTEILLLGL
LKIVESDIAM SPLQYLTFPL LHTPSLSNGV SSQKCPRILN SKALGLLRRA RVSRSKKEAD
SEGFPQQLLS SWHIAPVHLP LLGQNCWPHL SEGFSVSLWF NVECIHEAEG TTERGKKIKK
RNKSLILQDS SFDGTENNRP EGAEHINHGE RLIEEGCIHM ISLGSKALMI QVWADPHNGT
FIFRVCMDSN DDMKAVLLAQ AESQKNIFLP SKWQHLVLTY LEQPQGKKSI HGKISIWVSG
QRKPDVTLDF ILPRKTNLSS DSNKTFCMIG HCLSSQEDIL QLAGKWDLGN LLLFNGAKIG
SQEAFYLYAC GPNHTSIMPC KYGKPVNDYS KYINKEILQC EQIRELFMTK KDVDIGLLIE
SLSVVYTTYC PAQYTIYEPV IRLKGQMKTQ LSQRPFSSKE VQSILLEPHH IKSLRPTERK
TIQSILHEIG GTGVFVFLFA RVVELSSCEE TQALALRVIL SLIKYNQQRM CELENCNGLS
VIHQVLIKQK CIVGFHILKI LLEGCCGEDI IHINENGEFT LDVESNAIIQ DVKLLEELLL
DWKIWNKAEA CVWETLLAAL EVLIRADHHQ QMFNIKQLLK AQVVHHFLLT CQVVQEHKEG
QLTSLPREVC KSFVKIIAEV LGSPPDLELL TIIFNFLLAV HPPTNTYVCH NPTNFYFSLH
IDGKIFQEKV QSIMYLRHSS SGGKSVTSPG FMVISPSGFT ASPPEGNNSS NIIPRRMAVN
MLRSRSLPAF PTSSPLMQPR KLTGSLGCSI DKLQNIADNY VTSRPEKWNP LGSSETLKTG
KEDAFLSSCE SARTVCEMEA VLPAQASVSG VPKGSLGFPV VKELGAEPRS DDDSPGDESC
PRRPDYLKGL ASFQGSHSTI ASLGLAFPSQ NGAAAVGRWP SLVDRNTDDW ENLAFSLRYE
PNYNRTTNAH SVTEDCLVPI CCGLYELLSG VLLILPDIML EDVMDKLIQA DTLLVLVNHP
SPAIQQGVIK LLDAYFTRAS KEQKDKFLKN RGFSLLANQL YLHRGTQELL ECFIEMFFGR
RIGLDEEFDL EDVKNLGLFQ KWSVIPILGL IETSLCDNVL LHSALLLLLQ ILNSCSKVAD
MLLDNGLLYV LCNTVAALNG LEKNVPLNEY RLLACDIQRL FIAVTIHACS SSGSQYFRVI
EDLIVLLGYL QNSKNKRTQN MAVALQFRVL QAAMEFIRTT ANHDSENLTN SFPLPSAPHH
AIFQKRKSIA GSIPMKGSII PHLPRRHFGS YGQLPMPFSF SPLNRDSSPF SPGSTTCVVP
LEAGPRKFPL AQTDSLLMKM RSVASDELNM MMQRRMSQEN PVQATETELA QRLQRLTILA
VNRIIYQEFN PDIIDILSTP ESATQSKNSV SQTEISEENI YHDQASVFNP FQKEIFTYLV
EGFKVSVGSS KTSGSKQQWT KILWSCKETF RMQLGRLLVH ILSPAHPSQE RKQIFEIVRE
PNHQEILRDC LSSSLQHGPK LVLYLSELIH NHHDELTEEE LDAAELLMNA LKSCGHKCSP
PSVSAKSDLV KMIKEEQKKY ETEEGVNKTT WQKRVNHNQQ SLFQRLDSKS KDISKIAADI
TQAVSLSQGI ERKKVIQHIR GMYKVDLSAS RHWQELIQQL THDRAVWYDP TYYPTSWQLD
PTEGPNRERR RLQRCYLTIP NKYLLRDRQK SGDVVKPPLS YLFEDKTHSS FSSTVKDKAA
SESIRVNRRC ISVAPSRETA GELLLGKCGM YFVEDNASDT VESSNLQGEL EPASFSWTYE
EIKEVHKRWW QLRDNAVEIF LTNGRTLLLA FDNTKVRDDV YHSILTNNLP NLLEYGNITA
LTNLWYTGQI TNFEYLTHLN KHAGRSFNDL MQYPVFPFIL ADYVSETLDL SDPSVYRNLS
KPIAVQYKEK EDRYVDTYKY LEEEYRKGAR EDDPMPPVQP YHYGSHYSNS GTVLHFLVRM
PPFTKMFLAY QDQSFDIPDR TFHSTNTTWR LSSFESMTDV KELIPEFFYL PEFLVNREGF
DFGVRQNGER VNHVNLPPWA RNDPRLFILI HRQALESDYV SQNICQWIDL VFGYKQKGKA
SVQAINVFHP ATYFGMDVSA VEDPVQRRAL ETMIKTYGQT PRQLFQSAHA SRPGSKLNIE
GELPAAVGLL VQFAFRETRE QVKEVTYPSP LSWIKGLKWG EYVGSPSAPV PVVCFSQPHG
ERFGSLQALP TRAICGLSRN FCLLMTYSKE QGVRSMNSTD IQWSAILSWG YADNVLRLKS
KQSEPPVNFI QSSPQYQVTS CAWVPDSCQL FTGSKCGVIT AYANRLTSST PSEIEMESQI
HLYGHTEEIT SLFVCKPYSI MISVSRDGTC IIWDLNRLCY VQSLAGHKSP VTAVSASETT
GDIATVCDSA GGGSDLRLWT VNGDLVGHVH CREIICSVAF SNQPEGVSIN VIAGGLENGV
VRLWSTWDLK PVREITFPKS NKPIVSLTFS CDGHHLYTAN SDGTVIAWCR KDQQRLKQPM
FYSFLSSYAA G
//
