ID F7C0B1_HORSE Unreviewed; 782 AA.
AC F7C0B1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Tetratricopeptide repeat domain 14 {ECO:0000313|Ensembl:ENSECAP00000012491.2};
GN Name=TTC14 {ECO:0000313|VGNC:VGNC:24611};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000012491.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000012491.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012491.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000012491.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012491.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7C0B1; -.
DR STRING; 9796.ENSECAP00000012491; -.
DR PaxDb; 9796-ENSECAP00000012491; -.
DR Ensembl; ENSECAT00000015532.4; ENSECAP00000012491.2; ENSECAG00000014616.4.
DR CTD; 151613; -.
DR VGNC; VGNC:24611; TTC14.
DR GeneTree; ENSGT00390000013701; -.
DR HOGENOM; CLU_020585_1_0_1; -.
DR InParanoid; F7C0B1; -.
DR OMA; IRKEEWY; -.
DR OrthoDB; 2918730at2759; -.
DR TreeFam; TF325777; -.
DR Proteomes; UP000002281; Chromosome 19.
DR Bgee; ENSECAG00000014616; Expressed in endometrium and 23 other cell types or tissues.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd00164; S1_like; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR039190; TTC14.
DR PANTHER; PTHR23184; TETRATRICOPEPTIDE REPEAT PROTEIN 14; 1.
DR PANTHER; PTHR23184:SF9; TETRATRICOPEPTIDE REPEAT PROTEIN 14; 1.
DR Pfam; PF13414; TPR_11; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50126; S1; 1.
DR PROSITE; PS50005; TPR; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT DOMAIN 126..208
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REPEAT 316..349
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 350..383
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 29..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..523
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..644
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..749
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 782 AA; 89781 MW; D125C1A1A05C1CDB CRC64;
MDRDLLRQSL NYHGPSLLSL LRSEQQDNPH FRSLLGSGAE PARGPPPQQQ LQGRKEKRVD
NTEIQKFISK KADLLFALSW KSDAPATSEV NEDNEDHYAI MPPLEQFMEI PSMDRRELFF
RDIERGDIVI GRISSIREFG FFMVLICLGS GIMRDISHLE ITALCPLRDV PSHSNHGDPL
SYYQTGDIIR AGIKDIDRYH EKLAVSLYSS SLPPHLSGIK LGVISSEELP LYYSYIFVIF
FLRRSVELNS NSLESYENIM ESSLGFVNPG VVEFLLGKLG IDESNPPSLM RGLQSKNFSE
DDFASALRKK QSASWALKCV KIGVDYFKVG RHVDAMNEYN KALEIDKQNV EALVARGALY
ATKGSLNKAI EDFELALENC PTHRNARKYL CQTLVERGGQ LEEEEKFLNA ESYYKKALAL
DETFKDAEDA LQKLHKYMQK SLELREKQAE KEEKQKTKKI ETSAEKLRKL LKEEKRLKKK
RRKSTSSSSS VSSADESVSS SSSSSSSGHK RHKKRKRNRS ESSRSSKRHS AKASSNQIDQ
NRKDEYFPVP TNTSASFLNQ KQEVEKLLEK QDRLPYQKKQ VKEKDRCPLS SSSVEIPDDF
GGRSEDPRDF YDSCKTQAGS SKTEKPYKSE RHFSSRRDSS DSFCRNSEDK VKIYGYRRFE
KDIEGRKEHS RRWEPGSLRY STSPASSDYS WKSVEKYKKY AYSGSRDFSR HEQRHQLNKN
QGEYEREDNY EEDIKKEVPE EDGLNIKEQS ESGVKKNLPQ NLVNIFNQIA AFEKEKGNKP
KN
//
