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Database: UniProt
Entry: F7C2B6_ORNAN
LinkDB: F7C2B6_ORNAN
Original site: F7C2B6_ORNAN 
ID   F7C2B6_ORNAN            Unreviewed;       456 AA.
AC   F7C2B6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   16-OCT-2019, entry version 54.
DE   SubName: Full=ETS variant 6 {ECO:0000313|Ensembl:ENSOANP00000022963};
GN   Name=ETV6 {ECO:0000313|Ensembl:ENSOANP00000022963};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000022963, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000022963}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000022963};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594391}.
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DR   STRING; 9258.ENSOANP00000022963; -.
DR   Ensembl; ENSOANT00000022967; ENSOANP00000022963; ENSOANG00000014578.
DR   eggNOG; KOG3804; Eukaryota.
DR   eggNOG; ENOG4111K4J; LUCA.
DR   GeneTree; ENSGT00940000159508; -.
DR   InParanoid; F7C2B6; -.
DR   OMA; IENNHCP; -.
DR   TreeFam; TF318679; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000014578; Expressed in 6 organ(s), highest expression level in heart.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0071425; P:hematopoietic stem cell proliferation; IEA:Ensembl.
DR   GO; GO:0097152; P:mesenchymal cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0022008; P:neurogenesis; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007296; P:vitellogenesis; IEA:Ensembl.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   DNA-binding {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT   DOMAIN       44    128       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      343    424       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION      164    266       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    167    198       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   456 AA;  52980 MW;  481B66FC8B0025D2 CRC64;
     PSQRVTQISL DNQNNPSLFP HPSPLTLYSF PPPHPTTTKD PLRAVSENFG SVRIPFHLCL
     QPVSWSRDDV GQWLKWAEKE FSLRPIDNNT FEMNGKALLL LTKEDFRYRC PHSGDVLYEL
     LQHILKQRKT RMLFSPFFHP GNSIHTQPEV LVPQNHELDN CLQRASRPPV ESVQHNPPTI
     ELLHRSRSPV TTNHRPSPDP DQRPLRSPLD NMIRRLSPAE RVSGPRLHQE GGHQEPYPLC
     VSPMENNHCP PTSEGPAKPS SPRPESARVI QLMPSPIMHP LILNPRHSVD FKQSRLAEDG
     LHREGKPINL SHREDLAYVN HIMVSVSPPE DHAVPIGRIA DCRLLWDYVY QLLSDSRYEN
     FIRWEDKESK IFRIVDPNGL ARLWGNHKNR TNMTYEKMSR ALRHYYKLNI IRKEPGQRLL
     FRFMKTPDEI MSGRTDRLEH LESQELDEQI YQEDEC
//
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